A Knowledge Based Approach to Drug Repurposing for Socially Important and Rare Diseases
RSF - DST Project # 16-45-02012 - INT/RUS/RSF/12

World wide approved drugs

Database contains information on about 3,936 medications, including the name of the drug, synonyms, the structural formula of the drug substance, pharmacotherapeutic fields and mechanisms of action.

One may browse the records in the database or search for a particular drug using drug name as a query.


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Structure Brand Name Target Pharmacotheraputic application Pharmacological class Approved link PDB link PASSOnline prediction
Structure Brand Name Target Pharmacotheraputic application Pharmacological class Approved link PDB link PASSOnline prediction
Click to view acalabrutinib Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8912) Acalabrutinib is a small-molecule inhibitor of BTK. Acalabrutinib and its active metabolite, ACP-5862, form a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B cell antigen receptor (BCR) and cytokine receptor pathways. In B cells, BTK signaling results in activation of pathways necessary for B-cell proliferation, trafficking, chemotaxis, an adhesion. In nonclinical studies, acalabrutinib inhibited BTK mediated activation of downstream signaling proteins CD86 and CD69 and inhibited malignant B-cell proliferation and survival. Kinase Inhibitor (Code: N0000175605) Tyrosine Kinase Inhibitors (Code: N0000020001) 2017-10-31 FDA
Click to view latanoprostene bunod Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9635) Prostaglandin F2-alpha receptor (Organism: Bos taurus, class: GPCR, accessions: P37289, gene: PTGFR, swissprot: PF2R_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1050) Latanoprostene bunod is thought to lower intraocular pressure by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Intraocular pressure is a major modifiable risk factor for glaucoma progression. Reduction of intraocular pressure reduces risk of glaucomatous visual field loss. 2017-11-02 FDA
Click to view letermovir DNA terminase complex (Organism: Human cytomegalovirus (strain Merlin), class: Enzyme, accessions: F5HC79|F5HCU8|F5HGI9, gene: TRM1|TRM2|TRM3, swissprot: TRM1_HCMVM|TRM2_HCMVM|TRM3_HCMVM) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209939Orig1s000,209940Orig1s000lbl.pdf) Letermovir inhibits the CMV DNA terminase complex (pUL51, pUL56, and pUL89) which is required for viral DNA processing and packaging. Biochemical characterization and electron microscopy demonstrated that letermovir affects the production of proper unit length genomes and interferes with virion maturation. Genotypic characterization of virus resistant to letermovir confirmed that letermovir targets the terminase complex. Cytomegalovirus DNA Terminase Complex Inhibitor (Code: N0000193800) DNA Terminase Complex Inhibitors (Code: N0000193801) Cytochrome P450 3A Inhibitors (Code: N0000190114) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Cytochrome P450 2C8 Inhibitors (Code: N0000187062) Cytochrome P450 2C9 Inducers (Code: N0000185507) Cytochrome P450 2C19 Inducers (Code: N0000185607) 2017-11-08 FDA
Click to view vaborbactam Vaborbactam is a non-suicidal beta-lactamase inhibitor that protects meropenem from degradation by certain serine beta-lactamases such as Klebsiella pneumoniae carbapenemase (KPC). Vaborbactam does not have any antibacterial activity. Vaborbactam does not decrease the activity of meropenem against meropenem-susceptible organisms. beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) 2017-08-29 FDA 4XUX
4XUZ
Click to view levornidazole Levornidazole is a nitroimidazole derivative, which is mediated through the reduction in anaerobic environment into amino or the formation of free radicals from the nitro, interacting with celluar components, results in the death of microorganisms. It is indicated for the treatment of a variety of infectious diseases caused by sensitive anaerobic bacteria. 2009-08-13 China Food and Drug Administration (CFDA)
Click to view morinidazole Morinidazole is a nitroimidazole antibiotic indicated for the treatment of sensitive anaerobic bacterial infections including appendicitis and pelvic inflammatory disease caused by anaerobic bacteria. 2014-02-24 China Food and Drug Administration (CFDA)
Click to view forodesine Purine nucleoside phosphorylase (Organism: Homo sapiens, class: Enzyme, accessions: P00491, gene: PNP, swissprot: PNPH_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17897085) Purine nucleoside phosphorylase (Organism: Bos taurus, class: Unclassified, accessions: P55859, gene: PNP, swissprot: PNPH_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL218291) Purine nucleoside phosphorylase (Organism: Plasmodium falciparum, class: Unclassified, accessions: Q8T9Z7, gene: PNP, swissprot: Q8T9Z7_PLAFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL218291) Forodesine is a transition state analogue that binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction. 2017-03-30 PMDA
Click to view midostaurin Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5702) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase PAK 3 (Organism: Homo sapiens, class: Kinase, accessions: O75914, gene: PAK3, swissprot: PAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Myosin light chain kinase family member 4 (Organism: Homo sapiens, class: Kinase, accessions: Q86YV6, gene: MYLK4, swissprot: MYLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Organism: Homo sapiens, class: Kinase, accessions: P78356, gene: PIP4K2B, swissprot: PI42B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) cAMP-dependent protein kinase catalytic subunit beta (Organism: Homo sapiens, class: Kinase, accessions: P22694, gene: PRKACB, swissprot: KAPCB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) cAMP-dependent protein kinase catalytic subunit PRKX (Organism: Homo sapiens, class: Unclassified, accessions: P51817, gene: PRKX, swissprot: PRKX_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Glycogen synthase kinase-3 alpha (Organism: Homo sapiens, class: Kinase, accessions: P49840, gene: GSK3A, swissprot: GSK3A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase STK11 (Organism: Homo sapiens, class: Kinase, accessions: Q15831, gene: STK11, swissprot: STK11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) MAP/microtubule affinity-regulating kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27448, gene: MARK3, swissprot: MARK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) SRSF protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P78362, gene: SRPK2, swissprot: SRPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: P54646, gene: PRKAA2, swissprot: AAPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) RAC-alpha serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31749, gene: AKT1, swissprot: AKT1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) RAC-beta serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P31751, gene: AKT2, swissprot: AKT2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase LATS1 (Organism: Homo sapiens, class: Kinase, accessions: O95835, gene: LATS1, swissprot: LATS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase LATS2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRM7, gene: LATS2, swissprot: LATS2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase pim-1 (Organism: Homo sapiens, class: Kinase, accessions: P11309, gene: PIM1, swissprot: PIM1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase pim-3 (Organism: Homo sapiens, class: Kinase, accessions: Q86V86, gene: PIM3, swissprot: PIM3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) cAMP-dependent protein kinase catalytic subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P17612, gene: PRKACA, swissprot: KAPCA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase BRSK1 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDC3, gene: BRSK1, swissprot: BRSK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase MARK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9P0L2, gene: MARK1, swissprot: MARK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) MAP/microtubule affinity-regulating kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96L34, gene: MARK4, swissprot: MARK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type II subunit beta (Organism: Homo sapiens, class: Kinase, accessions: Q13554, gene: CAMK2B, swissprot: KCC2B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type II subunit delta (Organism: Homo sapiens, class: Kinase, accessions: Q13557, gene: CAMK2D, swissprot: KCC2D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type II subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: Q13555, gene: CAMK2G, swissprot: KCC2G_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Cyclin-dependent kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q9BWU1, gene: CDK19, swissprot: CDK19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: Q02779, gene: MAP3K10, swissprot: M3K10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Death-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53355, gene: DAPK1, swissprot: DAPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase PAK 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13153, gene: PAK1, swissprot: PAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase PAK 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13177, gene: PAK2, swissprot: PAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase BRSK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IWQ3, gene: BRSK2, swissprot: BRSK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein kinase C eta type (Organism: Homo sapiens, class: Kinase, accessions: P24723, gene: PRKCH, swissprot: KPCL_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tubulin alpha-1A chain (Organism: Rattus norvegicus, class: Structural, accessions: P68370, gene: Tuba1a, swissprot: TBA1A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) cGMP-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13976, gene: PRKG1, swissprot: KGP1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) cGMP-dependent protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13237, gene: PRKG2, swissprot: KGP2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase/endoribonuclease IRE1 (Organism: Homo sapiens, class: Kinase, accessions: O75460, gene: ERN1, swissprot: ERN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Inhibitor of nuclear factor kappa-B kinase subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: O15111, gene: CHUK, swissprot: IKKA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O00750, gene: PIK3C2B, swissprot: P3C2B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma (Organism: Homo sapiens, class: Kinase, accessions: O75747, gene: PIK3C2G, swissprot: P3C2G_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) U4/U6 small nuclear ribonucleoprotein Prp4 (Organism: Homo sapiens, class: Unclassified, accessions: O43172, gene: PRPF4, swissprot: PRP4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase SIK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2K2, gene: SIK3, swissprot: SIK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase RIO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BVS4, gene: RIOK2, swissprot: RIOK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Tankyrase-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H2K2, gene: TNKS2, swissprot: TNKS2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 32A (Organism: Homo sapiens, class: Kinase, accessions: Q8WU08, gene: STK32A, swissprot: ST32A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Inhibitor of nuclear factor kappa-B kinase subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O14920, gene: IKBKB, swissprot: IKKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity mitogen-activated protein kinase kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: P52564, gene: MAP2K6, swissprot: MP2K6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase PRP4 homolog (Organism: Homo sapiens, class: Kinase, accessions: Q13523, gene: PRPF4B, swissprot: PRP4B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual specificity protein kinase CLK3 (Organism: Homo sapiens, class: Kinase, accessions: P49761, gene: CLK3, swissprot: CLK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) RAC-gamma serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9Y243, gene: AKT3, swissprot: AKT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase pim-2 (Organism: Homo sapiens, class: Kinase, accessions: Q9P1W9, gene: PIM2, swissprot: PIM2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase Sgk3 (Organism: Homo sapiens, class: Kinase, accessions: Q96BR1, gene: SGK3, swissprot: SGK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase ICK (Organism: Homo sapiens, class: Kinase, accessions: Q9UPZ9, gene: ICK, swissprot: ICK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Mitogen-activated protein kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P45984, gene: MAPK9, swissprot: MK09_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL608533) Midostaurin is a small molecule that inhibits multiple receptor tyrosine kinases. In vitro biochemical or cellular assays have shown that midostaurin or its major human active metabolites CGP62221 and CGP52421 inhibit the activity of wild type FLT3, FLT3 mutant kinases (ITD and TKD), KIT (wild type and D816V mutant), PDGFR-alfa/beta, VEGFR2, as well as members of the serine/threonine kinase PKC (protein kinase C) family. Midostaurin demonstrated the ability to inhibit FLT3 receptor signaling and cell proliferation, and it induced apoptosis in leukemic cells expressing ITD and TKD mutant FLT3 receptors or overexpressing wild type FLT3 and PDGF receptors. Midostaurin also demonstrated the ability to inhibit KIT signaling, cell proliferation and histamine release and induce apoptosis in mast cells. antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) 2017-04-28 FDA 4NCT
Click to view macimorelin Growth hormone secretagogue receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: Q92847, gene: GHSR, swissprot: GHSR_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9745) Macimorelin stimulates GH release by activating growth hormone secretagogue receptors present in the pituitary and hypothalamus. Growth Hormone Secretagogue Receptor Agonist (Code: N0000193785) Growth Hormone Secretagogue Receptor Agonists (Code: N0000193786) 2017-12-20 FDA
Click to view baricitinib Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20363976) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2105759) Baricitinib is a selective and reversible inhibitor of Janus kinase (JAK)1 and JAK2. Janus kinases (JAKs) are enzymes that transduce intracellular signals from cell surface receptors for a number of cytokines and growth factors involved in haematopoiesis, inflammation and immune function. Within the intracellular signalling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which activate gene expression within the cell. Baricitinib modulates these signalling pathways by partially inhibiting JAK1 and JAK2 enzymatic activity, thereby reducing the phosphorylation and activation of STATs. 2017-02-13 EMA 4W9X
Click to view rucaparib Poly [ADP-ribose] polymerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P09874, gene: PARP1, swissprot: PARP1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf) Poly [ADP-ribose] polymerase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UGN5, gene: PARP2, swissprot: PARP2_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf) Poly [ADP-ribose] polymerase 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6F1, gene: PARP3, swissprot: PARP3_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209115s000lbl.pdf) Poly [ADP-ribose] polymerase 4 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKK3, gene: PARP4, swissprot: PARP4_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Tankyrase-1 (Organism: Homo sapiens, class: Enzyme, accessions: O95271, gene: TNKS, swissprot: TNKS1_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Tankyrase-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H2K2, gene: TNKS2, swissprot: TNKS2_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Poly [ADP-ribose] polymerase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q53GL7, gene: PARP10, swissprot: PAR10_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Poly [ADP-ribose] polymerase 12 (Organism: Homo sapiens, class: Enzyme, accessions: Q9H0J9, gene: PARP12, swissprot: PAR12_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Poly [ADP-ribose] polymerase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q460N5, gene: PARP14, swissprot: PAR14_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Poly [ADP-ribose] polymerase 15 (Organism: Homo sapiens, class: Enzyme, accessions: Q460N3, gene: PARP15, swissprot: PAR15_HUMAN) inhibitor (Source: http://dx.doi.org/10.1021/acs.jmedchem.6b00990) Rucaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair. In vitro studies have shown that rucaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis, and cell death. Increased rucaparib-induced cytotoxicity was observed in tumor cell lines with deficiencies in BRCA1/2 and other DNA repair genes. Rucaparib has been shown to decrease tumor growth in mouse xenograft models of human cancer with or without deficiencies in BRCA. Poly(ADP-Ribose) Polymerase Inhibitor (Code: N0000191623) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Poly(ADP-ribose) Polymerase Inhibitors (Code: D000067856) 2016-12-19 FDA 4BJC
4RV6
Click to view icotinib Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22088449) Icotinib is a new epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that developed and used in China for the treatment of patients with non-small cell lung cancer (NSCLC). 2011 China Food and Drug Administration (CFDA)
Click to view olmutinib Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/27357069) Olmutinib is an oral, third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) for the treatment of non-small cell lung cancer (NSCLC). Third-generation EGFR TKIs with covalent binding to the receptors demonstrate irreversible enzymatic inhibition of activating EGFR mutations and T790M mutation (a common reason for acquired EGFR TKI resistance), while sparing wild-type EGFR. 2016-05 Korean Food and Drug Administration (KFDA)
Click to view crisaborole Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207695s000lbl.pdf) Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Organism: Homo sapiens, class: Enzyme, accessions: P54750, gene: PDE1A, swissprot: PDE1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL484785) High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Organism: Homo sapiens, class: Enzyme, accessions: Q13946, gene: PDE7A, swissprot: PDE7A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL484785) Crisaborole is a phosphodiesterase 4 (PDE-4) inhibitor. PDE-4 inhibition results in increased intracellular cyclic adenosine monophosphate (cAMP) levels. The specific mechanism(s) by which crisaborole exerts its therapeutic action for the treatment of atopic dermatitis is not well defined. antipsoriatic (Code: CHEBI:50748) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Phosphodiesterase 4 Inhibitor (Code: N0000182961) Phosphodiesterase 4 Inhibitors (Code: N0000182960) 2016-12-14 FDA
Click to view radotinib Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/25676420) A second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. 2012-01-05 Korean Food and Drug Administration (KFDA)
Click to view lifitegrast Integrin alpha-L/beta-2 (Organism: Homo sapiens, class: Adhesion, accessions: P05107|P20701, gene: ITGAL|ITGB2, swissprot: ITAL_HUMAN|ITB2_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208073s000lbl.pdf) Intercellular adhesion molecule 1 (Organism: Homo sapiens, class: Unclassified, accessions: P05362, gene: ICAM1, swissprot: ICAM1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2048028) a lymphocyte function-associated antigen-1 ( LFA-1) antagonist, blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1), LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell activation and migration to target tissues anti-inflammatory drug (Code: CHEBI:35472) Lymphocyte Function-Associated Antigen-1 Antagonist (Code: N0000192701) Lymphocyte Function-Associated Antigen-1 Antagonists (Code: N0000192700) Ophthalmic Solutions (Code: D009883) Pharmaceutical Solutions (Code: D019999) 2016-07-11 FDA
Click to view pemafibrate Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/17553678) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/17553678) Peroxisome proliferator-activated receptor delta (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q03181, gene: PPARD, swissprot: PPARD_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/17553678) Pemafibrate is a selective PPAR-alpha modulator (SPPARM-alpha) that has antihyperlipidaemic activity. 2017-07-03 PMDA
Click to view zabofloxacin Zabofloxacin is a fluoroquinolone antibiotic with enhanced in-vitro activity against Streptococcus pneumoniae, including strains resistant to other antibiotics. The spectrum of activity of Zabofloxacin includes those bacterial strains that are responsible for most community-acquired respiratory infections. 2015-03-20 Korean Food and Drug Administration (KFDA)
Click to view imrecoxib Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/15210067) Prostaglandin G/H synthase 2 (Organism: Mus musculus, class: Enzyme, accessions: Q05769, gene: Ptgs2, swissprot: PGH2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL504535) Prostaglandin G/H synthase 1 (Organism: Mus musculus, class: Enzyme, accessions: P22437, gene: Ptgs1, swissprot: PGH1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL504535) Imrecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor indicated for treatment of osteoarthritis. 2011-05-20 China Food and Drug Administration (CFDA)
Click to view enasidenib Isocitrate dehydrogenase [NADP], mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P48735, gene: IDH2, swissprot: IDHP_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf) Enasidenib is a small molecule inhibitor of the isocitrate dehydrogenase 2 (IDH2) enzyme. Enasidenib targets the mutant IDH2 variants R140Q, R172S, and R172K at approximately 40-fold lower concentrations than the wild-type enzyme in vitro. Inhibition of the mutant IDH2 enzyme by enasidenib led to decreased 2-hydroxyglutarate (2-HG) levels and induced myeloid differentiation in vitro and in vivo in mouse xenograft models of IDH2 mutated AML. In blood samples from patients with AML with mutated IDH2, enasidenib decreased 2-HG levels, reduced blast counts and increased percentages of mature myeloid cells. Isocitrate Dehydrogenase 2 Inhibitor (Code: N0000193615) Isocitrate Dehydrogenase 2 Inhibitors (Code: N0000193614) 2017-08-01 FDA 5I96
Click to view fluciclovine (18F) a radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with diagnostic imaging use Radioactive Diagnostic Agent (Code: N0000177914) Positron Emitting Activity (Code: N0000175869) 2016-05-27 FDA
Click to view hydrocortisone phosphate None 1960-08-06 FDA
Click to view meglumine 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium. Contrast Media (Code: D003287) Diagnostic Uses of Chemicals (Code: D064907) 1974-04-30 FDA
Click to view cefathiamidine first generation of cephalosporin antibacterial used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis 2012-12-11 China Food and Drug Administration (CFDA)
Click to view eldecalcitol Vitamin D3 receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P11473, gene: VDR, swissprot: VDR_HUMAN) agonist (Source: http://www.kegg.jp/entry/D07578) Vitamin D3 receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P13053, gene: Vdr, swissprot: VDR_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2783) an analog of vitamin D for the treatment of osteoporosis Bone Density Conservation Agents (Code: D050071) 2011-01-21 PMDA 3WGP
Click to view pentapiperium metilsulfate None
Click to view pimavanserin 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) inverse agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207318lbl.pdf) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) inverse agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/16469866) an atypical antipsychotic, mechanism of action of pimavanserin in the treatment of hallucinations and delusions associated with Parkinson's disease psychosis is unknown. However, the effect of pimavanserin could be mediated through a combination of inverse agonist and antagonist activity at serotonin 5-HT2A receptors and to a lesser extent at serotonin 5-HT2C receptors antipsychotic agent (Code: CHEBI:35476) serotonergic antagonist (Code: CHEBI:48279) Atypical Antipsychotic (Code: N0000175430) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Serotonin 5-HT2 Receptor Agonists (Code: D058826) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Tranquilizing Agents (Code: D014149) 2016-04-29 FDA
Click to view opicapone Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24847974) Catechol O-methyltransferase (Organism: Mus musculus, class: Enzyme, accessions: O88587, gene: Comt, swissprot: COMT_MOUSE) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8988) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8988) a peripheral, selective and reversible catechol-O-methyltransferase (COMT) inhibitor endowed with a high binding affinity (sub-picomolar) that translates into a slow complex dissociation rate constant and a long duration of action (>24 hours) in vivo Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Catechol O-Methyltransferase Inhibitors (Code: D065098) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) 2016-06-24 EMA
Click to view neratinib Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208051s000lbl.pdf) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 25 (Organism: Homo sapiens, class: Kinase, accessions: O00506, gene: STK25, swissprot: STK25_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 36 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRP7, gene: STK36, swissprot: STK36_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 32B (Organism: Homo sapiens, class: Unclassified, accessions: Q9NY57, gene: STK32B, swissprot: ST32B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase PAK 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9NQU5, gene: PAK6, swissprot: PAK6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Dual specificity mitogen-activated protein kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O14733, gene: MAP2K7, swissprot: MP2K7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Wee1-like protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P0C1S8, gene: WEE2, swissprot: WEE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Casein kinase I isoform gamma-2 (Organism: Homo sapiens, class: Kinase, accessions: P78368, gene: CSNK1G2, swissprot: KC1G2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Receptor tyrosine-protein kinase erbB-3 (Organism: Homo sapiens, class: Kinase, accessions: P21860, gene: ERBB3, swissprot: ERBB3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: Q02779, gene: MAP3K10, swissprot: M3K10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase Nek2 (Organism: Homo sapiens, class: Kinase, accessions: P51955, gene: NEK2, swissprot: NEK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase Nek3 (Organism: Homo sapiens, class: Kinase, accessions: P51956, gene: NEK3, swissprot: NEK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase PAK 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13153, gene: PAK1, swissprot: PAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase PAK 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13177, gene: PAK2, swissprot: PAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 24 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6E0, gene: STK24, swissprot: STK24_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Casein kinase I isoform gamma-3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6M4, gene: CSNK1G3, swissprot: KC1G3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL180022) Neratinib is a kinase inhibitor that irreversibly binds to Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and HER4. In vitro, neratinib reduces EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in EGFR and/or HER2 expressing carcinoma cell lines. Neratinib human metabolites M3, M6, M7 and M11 inhibited the activity of EGFR, HER2 and HER4 in vitro. In vivo, oral administration of neratinib inhibited tumor growth in mouse xenograft models with tumor cell lines expressing HER2 and EGFR. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) P-Glycoprotein Inhibitors (Code: N0000185503) 2017-07-17 FDA
Click to view venetoclax Apoptosis regulator Bcl-2 (Organism: Homo sapiens, class: Cytosolic other, accessions: P10415, gene: BCL2, swissprot: BCL2_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208573s000lbl.pdf) Bcl-2-like protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q07817, gene: BCL2L1, swissprot: B2CL1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23291630) Apoptosis regulator Bcl-W (Organism: Homo sapiens, class: Cytosolic other, accessions: Q92843, gene: BCL2L2, swissprot: B2CL2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23291630) Venetoclax is a selective and orally bioavailable small-molecule inhibitor of BCL-2, an anti-apoptotic protein. Overexpression of BCL-2 has been demonstrated in CLL cells where it mediates tumor cell survival and has been associated with resistance to chemotherapeutics. Venetoclax helps restore the process of apoptosis by binding directly to the BCL-2 protein, displacing pro-apoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilization and the activation of caspases. In nonclinical studies, venetoclax has demonstrated cytotoxic activity in tumor cells that overexpress BCL-2. antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) BCL-2 Inhibitor (Code: N0000192515) Increased Cellular Death (Code: N0000009176) P-Glycoprotein Inhibitors (Code: N0000185503) 2016-04-11 FDA
Click to view brivaracetam Synaptic vesicle glycoprotein 2A (Organism: Homo sapiens, class: Transporter, accessions: Q7L0J3, gene: SV2A, swissprot: SV2A_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/18500360) Brivaracetam displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect. anticonvulsant (Code: CHEBI:35623) Epoxide Hydrolase Inhibitors (Code: N0000192345) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) 2016-01-14 EMA
Click to view bictegravir Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209360s000lbl.pdf) Bictegravir inhibits the strand transfer activity of HIV-1 integrase (integrase strand transfer inhibitor; INSTI), an HIV-1 encoded enzyme that is required for viral replication. Inhibition of integrase prevents the integration of linear HIV-1 DNA into host genomic DNA, blocking the formation of the HIV-1 provirus and propagation of the virus. 2018-02-07 FDA
Click to view tezacaftor Cystic fibrosis transmembrane conductance regulator (Organism: Homo sapiens, class: Ion channel, accessions: P13569, gene: CFTR, swissprot: CFTR_HUMAN) pharmacological chaperone (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210491lbl.pdf) Tezacaftor facilitates the cellular processing and trafficking of normal and select mutant forms of CFTR (including F508del-CFTR) to increase the amount of mature CFTR protein delivered to the cell surface. 2018-02-12 FDA
Click to view etelcalcetide Extracellular calcium-sensing receptor (Organism: Homo sapiens, class: GPCR, accessions: P41180, gene: CASR, swissprot: CASR_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8375) Etelcalcetide is a synthetic peptide calcimimetic agent which reduces parathyroid hormone (PTH) secretion through binding and activation of the calcium-sensing receptor. The reduction in PTH is associated with a concomitant decrease in serum calcium and phosphate levels. Calcium-sensing Receptor Agonist (Code: N0000175902) Increased Calcium-sensing Receptor Sensitivity (Code: N0000020081) 2016-11-11 EMA
Click to view mepiprazole psychotropic agent; tranquilizer in schizophrenia; possible chronobiotic agent for therapy in circadian rhythm desynchronization; RN given refers to parent cpd; RN for EMD 16923 with MF unknown: 52499-69-1
Click to view lorpiprazole None
Click to view elobixibat Ileal sodium/bile acid cotransporter (Organism: Homo sapiens, class: Transporter, accessions: Q12908, gene: SLC10A2, swissprot: NTCP2_HUMAN) inhibitor (Source: http://dx.doi.org/10.1016/S0016-5085(10)61017-7) Elobixibat is an IBAT inhibitor approved in Japan for the treatment of chronic constipation. IBAT is the bile acid/sodium symporter responsible for the reuptake of bile acids in the ileum which is the initial step in the enterohepatic circulation. By inhibiting the uptake of bile acids, elobixibat increases the bile acid concentration in the gut, and this accelerates intestinal passage and softens the stool. 2018-01-19 PMDA
Click to view apalutamide Androgen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P10275, gene: AR, swissprot: ANDR_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210951s000lbl.pdf) Apalutamide is an Androgen Receptor (AR) inhibitor that binds directly to the ligand-binding domain of the AR. Apalutamide inhibits AR nuclear translocation, inhibits DNA binding, and impedes AR-mediated transcription. A major metabolite, N-desmethyl apalutamide, is a less potent inhibitor of AR, and exhibited one-third the activity of apalutamide in an in vitro transcriptional reporter assay. Apalutamide administration caused decreased tumor cell proliferation and increased apoptosis leading to decreased tumor volume in mouse xenograft models of prostate cancer. 2018-02-14 FDA
Click to view velpatasvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 2a (isolate JFH-1), class: Polyprotein, accessions: Q99IB8, gene: None, swissprot: POLG_HCVJF) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 3a (isolate k3a) (HCV), class: Polyprotein, accessions: Q81495, gene: None, swissprot: POLG_HCVK3) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV), class: Polyprotein, accessions: Q9DHD6, gene: None, swissprot: POLG_HCVJP) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 5a (isolate SA13) (HCV), class: Polyprotein, accessions: O91936, gene: None, swissprot: POLG_HCVSA) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 6a (isolate 6a33) (HCV), class: Polyprotein, accessions: Q5I2N3, gene: None, swissprot: POLG_HCV6A) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208341s000lbl.pdf) pan-genotypic NS5A inhibitor for the treatment of chronic genotype 1-6 hepatitis C virus (HCV) infection antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Organic Anion Transporting Polypeptide 2B1 Inhibitors (Code: N0000190109) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) 2016-06-28 FDA
Click to view monoxerutin None
Click to view oxiglutatione A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized. 2008-07-24 FDA 1YKC
2GRT
2WDU
3FR3
3GX0
3M8U
4C0R
4F0B
4F0C
4IS0
4MRS
4MZW
4NAX
4TR0
4ZB6
4ZB8
4ZB9
4ZBA
5O00
5THY
Click to view elbasvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) inhibits NS5A protein of hepatitis C virus antiviral drug (Code: CHEBI:36044) hepatoprotective agent (Code: CHEBI:62868) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) 2016-01-28 FDA
Click to view etimicin None Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) 2014-09-15 China Food and Drug Administration (CFDA)
Click to view obeticholic acid Bile acid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q96RI1, gene: NR1H4, swissprot: NR1H4_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/207999s000lbl.pdf) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL566315) obeticholic acid is an agonist for FXR, a nuclear receptor expressed in the liver and intestine hepatoprotective agent (Code: CHEBI:62868) Farnesoid X Receptor Agonist (Code: N0000192561) Farnesoid X Receptor Agonists (Code: N0000192560) 2016-05-27 FDA 1OSV
1OT7
Click to view grazoprevir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 4a (isolate ED43), class: Polyprotein, accessions: O39929, gene: None, swissprot: POLG_HCVED) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208261Orig1s000lbl.pdf) has antiviral activity antiviral drug (Code: CHEBI:36044) hepatoprotective agent (Code: CHEBI:62868) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) 2016-01-28 FDA 3SUD
3SUE
3SUF
3SUG
Click to view climbazole Climbazole is a conazole fungicide. It is also use in shampoo and cleaner as an anti-dandruff agents and anti-bacteria agent.
Click to view trenbolone hexahydrobenzylcarbonate Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL197309) None
Click to view ixazomib Proteasome subunit beta type-5 (Organism: Homo sapiens, class: Enzyme, accessions: P28074, gene: PSMB5, swissprot: PSB5_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/208462lbl.pdf) Proteasome subunit beta type-2 (Organism: Homo sapiens, class: Enzyme, accessions: P49721, gene: PSMB2, swissprot: PSB2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20160034) Proteasome subunit beta type-1 (Organism: Homo sapiens, class: Enzyme, accessions: P20618, gene: PSMB1, swissprot: PSB1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20160034) an oral proteasome inhibitor with antineoplastic activity; MLN2238 is the biologically active form of MLN9708 orphan drug (Code: CHEBI:71031) proteasome inhibitor (Code: CHEBI:52726) antineoplastic agent (Code: CHEBI:35610) Proteasome Inhibitors (Code: N0000175075) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) 2015-11-20 FDA 5LF7
Click to view alfadolone acetate a neuroactive steroid and general anesthetic
Click to view cobimetinib Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22084396) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) allosteric modulator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7626) Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase 1 (MEK1) and MEK2. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. BRAF V600E and K mutations result in constitutive activation of the BRAF pathway which includes MEK1 and MEK2. In mice implanted with tumor cell lines expressing BRAF V600E, cobimetinib inhibited tumor cell growth. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) 2015-11-10 FDA 2015-11-10 EMA 4AN2
4LMN
Click to view saroglitazar Peroxisome proliferator-activated receptor alpha (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q07869, gene: PPARA, swissprot: PPARA_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/26171220) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/26171220) a PPARalpha and PPARgamma agonist hypoglycemic agent (Code: CHEBI:35526) 2013-02-25 CDSCO (INDIA)
Click to view pitolisant Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) inverse agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21615387) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL462605) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL462605) Pitolisant is a potent, orally active histamine H3-receptor antagonist/inverse agonist which, via its blockade of histamine auto-receptors enhances the activity of brain histaminergic neurons, a major arousal system with widespread projections to the whole brain. Pitolisant also modulates various neurotransmitter systems, increasing acetylcholine, noradrenaline and dopamine release in the brain. 2016-03-31 EMA
Click to view flibanserin 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022526lbl.pdf) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/12177684) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20840530) a serotonin receptor modulator with high affinity for the following serotonin (5-hydroxytryptamine or 5-T) receptors: agonist activity at 5-HT1A and antagonist activity at 5-HT2A. Flibanserin also has moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors, used in the treatment of premenopausal women with hypoactive sexual desire disorder serotonergic agonist (Code: CHEBI:35941) serotonergic antagonist (Code: CHEBI:48279) antidepressant (Code: CHEBI:35469) P-Glycoprotein Inhibitors (Code: N0000185503) 2015-08-18 FDA
Click to view trelagliptin Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26115728) Trelagliptin is an orally active dipeptidyl peptidase (DPP)-4 inhibitor developed by Takeda and approved in Japan for the treatment of type 2 diabetes mellitus. 2015-03-26 PMDA 5KBY
Click to view gluconolactone Glucosylceramidase (Organism: Homo sapiens, class: Enzyme, accessions: P04062, gene: GBA, swissprot: GLCM_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200829) None Calculi Dissolution Agent (Code: N0000175835) Irrigation (Code: N0000175534) 1990-10-02 FDA 1E6X
2E40
2VWG
2W39
3AZZ
3EQO
3VIF
4YNU
4ZLG
4ZOB
5XXM
Click to view angiotensin II Type-1 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P30556, gene: AGTR1, swissprot: AGTR1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2504) Type-2 angiotensin II receptor (Organism: Homo sapiens, class: GPCR, accessions: P50052, gene: AGTR2, swissprot: AGTR2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2504) Type-1B angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29089, gene: Agtr1b, swissprot: AGTRB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408403) Type-1 angiotensin II receptor (Organism: Bos taurus, class: GPCR, accessions: P25104, gene: AGTR1, swissprot: AGTR1_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408403) Type-1A angiotensin II receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25095, gene: Agtr1, swissprot: AGTRA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408403) Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure. Angiotensin II raises blood pressure by vasoconstriction and increased aldosterone release. Direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells, which stimulates Ca2+/calmodulin-dependent phosphorylation of myosin and causes smooth muscle contraction. Vasoconstrictor (Code: N0000192562) Vasoconstriction (Code: N0000009908) Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) 2017-12-21 FDA
Click to view faropenem medoxil Faropenem medoxomil is a prodrug of Faropenem sodium, the first oral penem-type antibiotic launched in 1997 in Japan. It is orally active and well absorbed through the gastro-intestinal tract, and rapidly converted to Faropenem. It is effective against various pathogenic bacteria, including the problematic antibiotic-resistant bacteria, PRSP (penicillin-resistant Streptococcus pneumoniae )
Click to view UREA C 14 Urea 14C is a urea molecule radiolabelled with a radioactive carbon-14. It is currently used for the Urea Breath Test (UBT) and is available as a rapid diagnostic test (marketed as PyTest) for the detection of Helicobacter pylori infections. 1997-05-09 FDA
Click to view copanlisib Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) inhibitor (Source: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Organism: Homo sapiens, class: Kinase, accessions: P42338, gene: PIK3CB, swissprot: PK3CB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24170767) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24170767) Copanlisib is an inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3K-alpha and PI3K-delta isoforms expressed in malignant B cells. Copanlisib has been shown to induce tumor cell death by apoptosis and inhibition of proliferation of primary malignant B cell lines. Copanlisib inhibits several key cell-signaling pathways, including B-cell receptor (BCR) signaling, CXCR12 mediated chemotaxis of malignant B cells, and NFkB signaling in lymphoma cell lines. Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) 2017-09-14 FDA 5G2N
Click to view sacubitril Neprilysin (Organism: Homo sapiens, class: Enzyme, accessions: P08473, gene: MME, swissprot: NEP_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207620Orig1s000lbl.pdf) inhibits neprilysin (neutral endopeptidase; NEP) via LBQ657, the active metabolite of the prodrug sacubitril and leads to increased levels of peptides that are degraded by neprilysin such as natriuretic peptides 2015-07-07 FDA
Click to view rolapitant Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206500s000lbl.pdf) An orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life. antiemetic (Code: CHEBI:50919) Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) P-Glycoprotein Inhibitors (Code: N0000185503) 2015-09-01 FDA
Click to view uridine triacetate Uridine triacetate is an acetylated form of uridine. Following oral administration, uridine triacetate is deacetylated by nonspecific esterases present throughout the body, yielding uridine in the systemic circulation of patients with hereditary orotic aciduria who cannot synthesize adequate quantities of uridine due to a genetic defect in uridine nucleotide synthesis. prodrug (Code: CHEBI:50266) neuroprotective agent (Code: CHEBI:63726) orphan drug (Code: CHEBI:71031) Pyrimidine Analog (Code: N0000191809) Pyrimidines (Code: N0000007587) Analogs/Derivatives (Code: N0000175452) 2015-09-04 FDA
Click to view olanexidine Olanexidine is a monobiguanide compound with bactericidal activity. 2015-07-03 PMDA
Click to view tivozanib Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004131/WC500239033.pdf) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/16982756) Tivozanib is an oral, once-daily, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI). It is a potent, selective and long half-life inhibitor of all three VEGF receptors and is designed to optimize VEGF blockade while minimizing off-target toxicities, potentially resulting in improved efficacy and minimal dose modifications. Tivozanib is indicated as first line treatment of adult patients with advanced renal cell carcinoma (RCC) and for adult patients who are VEGFR and mTOR pathway inhibitor-naive following disease progression after one prior treatment with cytokine therapy for advanced RCC. 2017-08-24 EMA
Click to view menadiol sodium diphosphate None 1941 FDA
Click to view brexpiprazole D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205422s000lbl.pdf) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/24947465) an atypical antipsychotic the efficacy of brexpiprazole may be mediated through a combination of partial agonist activity at serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors Atypical Antipsychotic (Code: N0000175430) Dopamine Agents (Code: D015259) Dopamine Agonists (Code: D018491) Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) 2015-07-10 FDA
Click to view eluxadoline Kappa-type opioid receptor (Organism: Cavia porcellus, class: GPCR, accessions: P41144, gene: OPRK1, swissprot: OPRK_CAVPO) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Kappa-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41145, gene: OPRK1, swissprot: OPRK_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22671931) Delta-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P41143, gene: OPRD1, swissprot: OPRD_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206940s000lbl.pdf) Delta-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533, gene: Oprd1, swissprot: OPRD_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2159122) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2159122) Eluxadoline is a mu-opioid receptor agonist; eluxadoline is also a delta opioid receptor antagonist and a kappa opioid receptor agonist. The binding affinities (Ki) of eluxadoline for the human mu and delta opioid receptors are 1.8 nM and 430 nM, respectively. The binding affinity (Ki) of eluxadoline for the human kappa opioid receptor has not been determined; however, the Ki for guinea pig cerebellum kappa opioid receptor is 55 nM. In animals, eluxadoline interacts with opioid receptors in the gut. mu-opioid receptor agonist (Code: CHEBI:55322) delta-opioid receptor antagonist (Code: CHEBI:59283) kappa-opioid receptor agonist (Code: CHEBI:59282) gastrointestinal drug (Code: CHEBI:55324) Gastrointestinal Agents (Code: D005765) Opioid mu-Receptor Agonists (Code: N0000191866) 2015-05-27 FDA
Click to view deoxycholic acid Cell membrane (Organism: None, class: Cell membrane, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206333Orig1s000lbl.pdf) Steroid Delta-isomerase (Organism: Pseudomonas putida, class: Unclassified, accessions: P07445, gene: ksi, swissprot: SDIS_PSEPU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL406393) fMet-Leu-Phe receptor (Organism: Homo sapiens, class: GPCR, accessions: P21462, gene: FPR1, swissprot: FPR1_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=610) G-protein coupled bile acid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDU6, gene: GPBAR1, swissprot: GPBAR_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=610) A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. Cytolytic Agent (Code: N0000191548) Decreased Cell Membrane Integrity (Code: N0000008476) Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) 2015-04-29 FDA 1E3V
1FM4
1OS6
2BJF
2OPX
2W1B
3DTU
3O01
3R9V
3RV5
3SEL
3SJ0
3SJ1
3SJ4
3ZQE
4A81
4A83
4A84
4AC9
4ACA
4ACB
4HAJ
4HB6
4HB8
4HBF
4HC3
4HDL
4QN9
4ZP0
Click to view triamcinolone hexacetonide Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016466s046lbl.pdf) synthetic glucocorticoid analog used for anti-inflammatory effects in disorders of many organ systems Anti-Inflammatory Agents (Code: D000893) 1969-07-29 FDA
Click to view ombitasvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206619s003lbl.pdf) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206619s003lbl.pdf) inhibits HCV NS5A protein antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) UGT1A1 Inhibitors (Code: N0000191272) 2014-11-20 EMA
Click to view isavuconazonium Aspergillus fumigatus (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207500Orig1s000lbl.pdf) Candida albicans (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207500Orig1s000lbl.pdf) Isavuconazonium sulfate is the prodrug of isavuconazole, an azole antifungal drug. Isavuconazole inhibits the synthesis of ergosterol, a key component of the fungal cell membrane, through the inhibition of cytochrome P-450 dependent enzyme lanosterol 14-alpha-demethylase. This enzyme is responsible for the conversion of lanosterol to ergosterol. An accumulation of methylated sterol precursors and a depletion of ergosterol within the fungal cell membrane weakens the membrane structure and function. Mammalian cell demethylation is less sensitive to isavuconazole inhibition. prodrug (Code: CHEBI:50266) orphan drug (Code: CHEBI:71031) Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) P-Glycoprotein Inhibitors (Code: N0000185503) 2015-03-06 FDA
Click to view isoflupredone acetate None
Click to view drofenine None
Click to view arformoterol Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/12090787) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021912s013lbl.pdf) Beta-2 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8K4Z4, gene: Adrb2, swissprot: ADRB2_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1363) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1363) the (R,R)-enantiomer of formoterol, is a selective long-acting beta2-adrenergic receptor agonist (beta2-agonist) that has two-fold greater potency than racemic formoterol bronchodilator agent (Code: CHEBI:35523) anti-asthmatic drug (Code: CHEBI:49167) beta-adrenergic agonist (Code: CHEBI:35522) Adrenergic beta2-Agonists (Code: N0000009922) beta2-Adrenergic Agonist (Code: N0000175779) 2006-10-06 FDA
Click to view tenofovir alafenamide a phosphonoamidate prodrug of tenofovir (2'deoxyadenosine monophosphate analog). Plasma exposure to tenofovir alafenamide allows for permeation into cells and then tenofovir alafenamide is intracellularly converted to tenofovir through hydrolysis by cathepsin A. Tenofovir is subsequently phosphorylated by cellular kinases to the active metabolite tenofovir diphosphate. Tenofovir diphosphate inhibits HIV replication through incorporation into viral DNA by the HIV reverse transcriptase, which results in DNA chain-termination antiviral drug (Code: CHEBI:36044) prodrug (Code: CHEBI:50266) 2015-05-11 FDA
Click to view avibactam Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q9EXV5, gene: blaUOE-1, swissprot: Q9EXV5_ECOLX) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23913691) a non-beta-lactam beta-lactamase inhibitor that inactivates some beta-lactamases and protects ceftazidime from degradation by certain beta-lactamases antibacterial drug (Code: CHEBI:36047) beta Lactamase Inhibitor (Code: N0000175930) beta Lactamase Inhibitors (Code: N0000000202) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) beta-Lactamase Inhibitors (Code: D065093) Enzyme Inhibitors (Code: D004791) 2015-02-25 FDA
Click to view daclatasvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20410884) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20410884) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2023898) an HCV NS5A inhibitor antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) 2014-09-15 EMA
Click to view palbociclib Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207103s000lbl.pdf) Cyclin-dependent kinase 6 (Organism: Homo sapiens, class: Kinase, accessions: Q00534, gene: CDK6, swissprot: CDK6_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207103s000lbl.pdf) Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Organism: Homo sapiens, class: Kinase, accessions: Q13627, gene: DYRK1A, swissprot: DYR1A_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/15542782) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/15542782) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) CDK2/Cyclin A (Organism: Homo sapiens, class: Kinase, accessions: P20248|P24941, gene: CCNA2|CDK2, swissprot: CCNA2_HUMAN|CDK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) Cyclin-dependent kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P50750, gene: CDK9, swissprot: CDK9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) Cyclin-dependent kinase 4/cyclin D1 (Organism: Homo sapiens, class: Kinase, accessions: P11802|P24385, gene: CCND1|CDK4, swissprot: CCND1_HUMAN|CDK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) CDK6/cyclin D1 (Organism: Homo sapiens, class: Kinase, accessions: P24385|Q00534, gene: CCND1|CDK6, swissprot: CCND1_HUMAN|CDK6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL189963) Palbociclib is an inhibitor of cyclin-dependent kinases (CDK) 4 and 6. Cyclin D1 and CDK4/6 are downstream of signaling pathways which lead to cellular proliferation. In vitro, palbociclib reduced cellular proliferation of estrogen receptor (ER)-positive breast cancer cell lines by blocking progression of the cell from G1 into S phase of the cell cycle. Treatment of breast cancer cell lines with the combination of palbociclib and antiestrogens leads to decreased retinoblastoma (Rb) protein phosphorylation resulting in reduced E2F expression and signaling, and increased growth arrest compared to treatment with each drug alone. In vitro treatment of ER-positive breast cancer cell lines with the combination of palbociclib and antiestrogens led to increased cell senescence compared to each drug alone, which was sustained for up to 6 days following palbociclib removal and was greater if antiestrogen treatment was continued. In vivo studies using a patient-derived ER-positive breast cancer xenograft model demonstrated that the combination of palbociclib and letrozole increased the inhibition of Rb phosphorylation, downstream signaling, and tumor growth compared to each drug alone. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) 2015-02-03 FDA 2EUF
5L2I
Click to view lenvatinib Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289601) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17943726) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206947s000lbl.pdf) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17943726) a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular functions, including fibroblast growth factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet derived growth factor receptor alpha (PDGFR?), KIT, and RET. orphan drug (Code: CHEBI:71031) antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) 2015-02-13 FDA 3WZD
5ZV2
Click to view decamethoxine a bisquaternary ammonium salt Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) None Ministry of Health of the Russian Federation
Click to view finafloxacin Pseudomonas aeruginosa (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21709094) Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21709094) Finafloxacin belongs to the fluoroquinolone class of antibacterials which involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination. antibacterial drug (Code: CHEBI:36047) Quinolone Antimicrobial (Code: N0000175937) Quinolones (Code: N0000007606) 2014-12-17 FDA
Click to view safinamide Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17030736) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL48582) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL48582) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL48582) Sigma non-opioid intracellular receptor 1 (Organism: Rattus norvegicus, class: Membrane receptor, accessions: Q9R0C9, gene: Sigmar1, swissprot: SGMR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL48582) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL48582) Safinamide acts through both dopaminergic and non-dopaminergic mechanisms of action. Safinamide is a highly selective and reversible MAO-B inhibitor causing an increase in extracellular levels of dopamine in the striatum. Safinamide is associated with state-dependent inhibition of voltage-gated sodium (Na+) channels, and modulation of stimulated release of glutamate. To what extent the nondopaminergic effects contribute to the overall effect has not been established. Monoamine Oxidase Type B Inhibitor (Code: N0000175762) Monoamine Oxidase-B Inhibitors (Code: N0000175761) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) 2014-03-30 EMA
Click to view ceftolozane Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs). Ceftolozane is an inhibitor of PBPs of P. aeruginosa (e.g., PBP1b, PBP1c, and PBP3) and E. coli (e.g., PBP3). Cephalosporin Antibacterial (Code: N0000175488) Cephalosporins (Code: N0000011161) 2014-12-19 FDA
Click to view acotiamide Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651906) A prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. 2013-03-25 PMDA
Click to view felypressin Vasopressin V1a receptor (Organism: Homo sapiens, class: GPCR, accessions: P37288, gene: AVPR1A, swissprot: V1AR_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/18655903) A synthetic analog of LYPRESSIN with a PHENYLALANINE substitution at residue 2. Felypressin is a vasoconstrictor with reduced antidiuretic activity. vasoconstrictor agent (Code: CHEBI:50514) vasopressin receptor agonist (Code: CHEBI:59727) Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662) 1969-12-31 New Zealand Medicines and Medical Devices Safety Authority
Click to view netupitant Substance-P receptor (Organism: Homo sapiens, class: GPCR, accessions: P25103, gene: TACR1, swissprot: NK1R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/16332435) a selective antagonist of human substance P/neurokinin 1 (NK1) receptors, inhibits substance P mediated emesis responses antiemetic (Code: CHEBI:50919) Neurokinin 1 Antagonists (Code: N0000010262) Substance P/Neurokinin-1 Receptor Antagonist (Code: N0000175786) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) 2014-10-10 FDA
Click to view ledipasvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24320933) Genome polyprotein (Organism: Hepatitis C virus genotype 1b (isolate BK), class: Polyprotein, accessions: P26663, gene: None, swissprot: POLG_HCVBK) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24320933) an inhibitor of the HCV NS5A protein, which is required for viral replication antiviral drug (Code: CHEBI:36044) Hepatitis C Virus NS5A Inhibitor (Code: N0000191256) P-Glycoprotein Inhibitors (Code: N0000185503) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) 2014-10-10 FDA
Click to view diquafosol P2Y purinoceptor 2 (Organism: Homo sapiens, class: GPCR, accessions: P41231, gene: P2RY2, swissprot: P2RY2_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/18232657) P2Y purinoceptor 4 (Organism: Homo sapiens, class: GPCR, accessions: P51582, gene: P2RY4, swissprot: P2RY4_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1736) purinoceptor P2Y(2) receptor agonist 2010-02-26 PMDA
Click to view belinostat Histone deacetylase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P56524, gene: HDAC4, swissprot: HDAC4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/12939461) Histone deacetylase 10 (Organism: Homo sapiens, class: Enzyme, accessions: Q969S8, gene: HDAC10, swissprot: HDA10_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 11 (Organism: Homo sapiens, class: Enzyme, accessions: Q96DB2, gene: HDAC11, swissprot: HDA11_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UKV0, gene: HDAC9, swissprot: HDAC9_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 6 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBN7, gene: HDAC6, swissprot: HDAC6_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 3 (Organism: Homo sapiens, class: Enzyme, accessions: O15379, gene: HDAC3, swissprot: HDAC3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 5 (Organism: Homo sapiens, class: Enzyme, accessions: Q9UQL6, gene: HDAC5, swissprot: HDAC5_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) Histone deacetylase 7 (Organism: Homo sapiens, class: Enzyme, accessions: Q8WUI4, gene: HDAC7, swissprot: HDAC7_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL408513) a hydroxamate-type inhibitor of histone deacetylase antineoplastic agent (Code: CHEBI:35610) Histone Deacetylase Inhibitor (Code: N0000175588) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Histone Deacetylase Inhibitors (Code: D056572) 2014-07-03 FDA 5EEN
Click to view imidafenacin Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/10428387) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10428387) Imidafenacin antagonizes subtypes M3 and M1 in vitro. In the urinary bladder, imidafenacin inhibits acetylcholine release by antagonizing subtype M1 and contraction of smooth muscles by antagonizing subtype M3. 2007-04-18 PMDA
Click to view nintedanib Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19522465) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Protein kinase C theta type (Organism: Homo sapiens, class: Kinase, accessions: Q04759, gene: PRKCQ, swissprot: KPCT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase type 1 (Organism: Homo sapiens, class: Kinase, accessions: Q14012, gene: CAMK1, swissprot: KCC1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase type IV (Organism: Homo sapiens, class: Kinase, accessions: Q16566, gene: CAMK4, swissprot: KCC4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Casein kinase I isoform epsilon (Organism: Homo sapiens, class: Kinase, accessions: P49674, gene: CSNK1E, swissprot: KC1E_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Myosin-IIIb (Organism: Homo sapiens, class: Kinase, accessions: Q8WXR4, gene: MYO3B, swissprot: MYO3B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PAK 3 (Organism: Homo sapiens, class: Kinase, accessions: O75914, gene: PAK3, swissprot: PAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UK32, gene: RPS6KA6, swissprot: KS6A6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) MAP/microtubule affinity-regulating kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27448, gene: MARK3, swissprot: MARK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q15418, gene: RPS6KA1, swissprot: KS6A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Microtubule-associated serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2H9, gene: MAST1, swissprot: MAST1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Casein kinase I isoform delta (Organism: Homo sapiens, class: Kinase, accessions: P48730, gene: CSNK1D, swissprot: KC1D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Homeodomain-interacting protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H422, gene: HIPK3, swissprot: HIPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Homeodomain-interacting protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2X6, gene: HIPK2, swissprot: HIPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Maternal embryonic leucine zipper kinase (Organism: Homo sapiens, class: Kinase, accessions: Q14680, gene: MELK, swissprot: MELK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Wee1-like protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P30291, gene: WEE1, swissprot: WEE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) NUAK family SNF1-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O60285, gene: NUAK1, swissprot: NUAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase ICK (Organism: Homo sapiens, class: Kinase, accessions: Q9UPZ9, gene: ICK, swissprot: ICK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase/endoribonuclease IRE1 (Organism: Homo sapiens, class: Kinase, accessions: O75460, gene: ERN1, swissprot: ERN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) MAP/microtubule affinity-regulating kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96L34, gene: MARK4, swissprot: MARK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase OSR1 (Organism: Homo sapiens, class: Kinase, accessions: O95747, gene: OXSR1, swissprot: OXSR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase Sgk3 (Organism: Homo sapiens, class: Kinase, accessions: Q96BR1, gene: SGK3, swissprot: SGK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) STE20/SPS1-related proline-alanine-rich protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UEW8, gene: STK39, swissprot: STK39_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity protein kinase CLK2 (Organism: Homo sapiens, class: Kinase, accessions: P49760, gene: CLK2, swissprot: CLK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) G protein-coupled receptor kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q8WTQ7, gene: GRK7, swissprot: GRK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Myosin light chain kinase family member 4 (Organism: Homo sapiens, class: Kinase, accessions: Q86YV6, gene: MYLK4, swissprot: MYLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Homeodomain-interacting protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q86Z02, gene: HIPK1, swissprot: HIPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity protein kinase CLK1 (Organism: Homo sapiens, class: Kinase, accessions: P49759, gene: CLK1, swissprot: CLK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 17B (Organism: Homo sapiens, class: Kinase, accessions: O94768, gene: STK17B, swissprot: ST17B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase MARK2 (Organism: Homo sapiens, class: Kinase, accessions: Q7KZI7, gene: MARK2, swissprot: MARK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-5 (Organism: Homo sapiens, class: Kinase, accessions: O75582, gene: RPS6KA5, swissprot: KS6A5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (Organism: Homo sapiens, class: Kinase, accessions: P15735, gene: PHKG2, swissprot: PHKG2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-3 (Organism: Homo sapiens, class: Kinase, accessions: P51812, gene: RPS6KA3, swissprot: KS6A3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Myosin light chain kinase, smooth muscle (Organism: Homo sapiens, class: Kinase, accessions: Q15746, gene: MYLK, swissprot: MYLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: Q02779, gene: MAP3K10, swissprot: M3K10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PAK 7 (Organism: Homo sapiens, class: Kinase, accessions: Q9P286, gene: PAK5, swissprot: PAK5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 17A (Organism: Homo sapiens, class: Kinase, accessions: Q9UEE5, gene: STK17A, swissprot: ST17A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 11 (Organism: Homo sapiens, class: Kinase, accessions: Q16584, gene: MAP3K11, swissprot: M3K11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-4 (Organism: Homo sapiens, class: Kinase, accessions: O75676, gene: RPS6KA4, swissprot: KS6A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity protein kinase CLK4 (Organism: Homo sapiens, class: Kinase, accessions: Q9HAZ1, gene: CLK4, swissprot: CLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Death-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UIK4, gene: DAPK2, swissprot: DAPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase type 1D (Organism: Homo sapiens, class: Kinase, accessions: Q8IU85, gene: CAMK1D, swissprot: KCC1D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase type 1G (Organism: Homo sapiens, class: Kinase, accessions: Q96NX5, gene: CAMK1G, swissprot: KCC1G_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: Q15349, gene: RPS6KA2, swissprot: KS6A2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Organism: Homo sapiens, class: Kinase, accessions: Q16816, gene: PHKG1, swissprot: PHKG1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Casein kinase II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: P68400, gene: CSNK2A1, swissprot: CSK21_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase STK11 (Organism: Homo sapiens, class: Kinase, accessions: Q15831, gene: STK11, swissprot: STK11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Rhodopsin kinase (Organism: Homo sapiens, class: Kinase, accessions: Q15835, gene: GRK1, swissprot: RK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium/calmodulin-dependent protein kinase type II subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: Q9UQM7, gene: CAMK2A, swissprot: KCC2A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase MARK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9P0L2, gene: MARK1, swissprot: MARK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Bone morphogenetic protein receptor type-2 (Organism: Homo sapiens, class: Kinase, accessions: Q13873, gene: BMPR2, swissprot: BMPR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase LATS2 (Organism: Homo sapiens, class: Kinase, accessions: Q9NRM7, gene: LATS2, swissprot: LATS2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Inhibitor of nuclear factor kappa-B kinase subunit alpha (Organism: Homo sapiens, class: Kinase, accessions: O15111, gene: CHUK, swissprot: IKKA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Organism: Homo sapiens, class: Kinase, accessions: Q9Y463, gene: DYRK1B, swissprot: DYR1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PRP4 homolog (Organism: Homo sapiens, class: Kinase, accessions: Q13523, gene: PRPF4B, swissprot: PRP4B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PknB (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Kinase, accessions: P9WI81, gene: pknB, swissprot: PKNB_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Calcium-dependent protein kinase 1 (Organism: Plasmodium falciparum, class: Kinase, accessions: P62344, gene: CPK1, swissprot: CDPK1_PLAF7) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 24 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6E0, gene: STK24, swissprot: STK24_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Organism: Homo sapiens, class: Kinase, accessions: P54646, gene: PRKAA2, swissprot: AAPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 17 (Organism: Homo sapiens, class: Kinase, accessions: Q00537, gene: CDK17, swissprot: CDK17_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Death-associated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: O43293, gene: DAPK3, swissprot: DAPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase receptor R3 (Organism: Homo sapiens, class: Kinase, accessions: P37023, gene: ACVRL1, swissprot: ACVL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Activin receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: P36896, gene: ACVR1B, swissprot: ACV1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase DCLK3 (Organism: Homo sapiens, class: Kinase, accessions: Q9C098, gene: DCLK3, swissprot: DCLK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 14 (Organism: Homo sapiens, class: Kinase, accessions: O94921, gene: CDK14, swissprot: CDK14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Eukaryotic translation initiation factor 2-alpha kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9P2K8, gene: EIF2AK4, swissprot: E2AK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 18 (Organism: Homo sapiens, class: Kinase, accessions: Q07002, gene: CDK18, swissprot: CDK18_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase LATS1 (Organism: Homo sapiens, class: Kinase, accessions: O95835, gene: LATS1, swissprot: LATS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase PAK 2 (Organism: Homo sapiens, class: Kinase, accessions: Q13177, gene: PAK2, swissprot: PAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (Organism: Homo sapiens, class: Kinase, accessions: P78356, gene: PIP4K2B, swissprot: PI42B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) 3-phosphoinositide-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: O15530, gene: PDPK1, swissprot: PDPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase D2 (Organism: Homo sapiens, class: Kinase, accessions: Q9BZL6, gene: PRKD2, swissprot: KPCD2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) SRSF protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P78362, gene: SRPK2, swissprot: SRPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Dual specificity mitogen-activated protein kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P45985, gene: MAP2K4, swissprot: MP2K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Vascular endothelial growth factor receptor 2 (Organism: Mus musculus, class: Kinase, accessions: P35918, gene: Kdr, swissprot: VGFR2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase 33 (Organism: Homo sapiens, class: Kinase, accessions: Q9BYT3, gene: STK33, swissprot: STK33_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Glycogen synthase kinase-3 beta (Organism: Homo sapiens, class: Kinase, accessions: P49841, gene: GSK3B, swissprot: GSK3B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase Chk1 (Organism: Homo sapiens, class: Kinase, accessions: O14757, gene: CHEK1, swissprot: CHK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Glycogen synthase kinase-3 alpha (Organism: Homo sapiens, class: Kinase, accessions: P49840, gene: GSK3A, swissprot: GSK3A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) cGMP-dependent protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13976, gene: PRKG1, swissprot: KGP1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase N1 (Organism: Homo sapiens, class: Kinase, accessions: Q16512, gene: PKN1, swissprot: PKN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL502835) Boehringer Ingelheim's triple kinase inhibitor blocking VEGFR, PDGFR and FGFR antineoplastic agent (Code: CHEBI:35610) angiogenesis inhibitor (Code: CHEBI:48422) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) 2014-10-15 FDA 3C7Q
5MAF
5TE0
Click to view cetilistat Pancreatic triacylglycerol lipase (Organism: Homo sapiens, class: Enzyme, accessions: P16233, gene: PNLIP, swissprot: LIPP_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/18500680) lipase inhibitor in randomized, placebo-controlled study of weight reduction in obese patients (3/2007) Anti-Obesity Agents (Code: D019440) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Lipid Regulating Agents (Code: D057847) 2013-09-20 PMDA
Click to view efinaconazole Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/11302816) Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/11302816) Lanosterol 14-alpha demethylase (Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892), class: Enzyme, accessions: F2SHH3, gene: None, swissprot: F2SHH3_TRIRC) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2103877) Efinaconazole is an azole antifungal. Efinaconazole inhibits fungal lanosterol 14-alpha demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) 2014-06-06 FDA
Click to view favipiravir H1N1 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H2N2 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H3N2 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) H1N5 subtype (Organism: None, class: Virus, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19428599) A pyrazinecarboxamide derivative with activity against RNA viruses. Favipiravir is converted to the ribofuranosyltriphosphate derivative by host enzymes and selectively inhibits the influenza viral RNA-dependent RNA polymerase. 2014-02-03 PMDA
Click to view topiroxostat Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19783139) xanthine oxidoreductase inhibitor Enzyme Inhibitors (Code: D004791) 2013-04-26 PMDA 1V97
Click to view asunaprevir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22869577) an NS3 protease inhibitor against hepatitis C virus Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) 2014-06-24 PMDA 4NWL
4WF8
4WH6
5EQS
Click to view ipragliflozin Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22139434) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/22139434) Sodium/glucose cotransporter 1 (Organism: Mus musculus, class: Transporter, accessions: Q8C3K6, gene: Slc5a1, swissprot: SC5A1_MOUSE) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9394) Sodium/glucose cotransporter 1 (Organism: Rattus norvegicus, class: Transporter, accessions: P53790, gene: Slc5a1, swissprot: SC5A1_RAT) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9394) Sodium/glucose cotransporter 2 (Organism: Mus musculus, class: Transporter, accessions: Q923I7, gene: Slc5a2, swissprot: SC5A2_MOUSE) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9394) Sodium/glucose cotransporter 2 (Organism: Rattus norvegicus, class: Transporter, accessions: P53792, gene: Slc5a2, swissprot: SC5A2_RAT) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=9394) inhibits sodium-dependent glucose co-transporter 2 (SGLT2) 2014-11-29 PMDA
Click to view luseogliflozin Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20302302) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20302302) an antidiabetic agent that inhibits sodium-dependent glucose cotransporter 2 (SGLT2) 2014-03-24 PMDA
Click to view suvorexant Orexin receptor type 1 (Organism: Homo sapiens, class: GPCR, accessions: O43613, gene: HCRTR1, swissprot: OX1R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20565075) Orexin receptor type 2 (Organism: Homo sapiens, class: GPCR, accessions: O43614, gene: HCRTR2, swissprot: OX2R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20565075) Orexin receptor type 1 (Organism: Mus musculus, class: GPCR, accessions: P58307, gene: Hcrtr1, swissprot: OX1R_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1083659) Orexin receptor type 2 (Organism: Mus musculus, class: GPCR, accessions: P58308, gene: Hcrtr2, swissprot: OX2R_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1083659) a highly selective antagonist for orexin receptors OX1R and OX2R, the orexin neuropeptide signaling system is a central promoter of wakefulness, blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive central nervous system depressant (Code: CHEBI:35488) Orexin Receptor Antagonist (Code: N0000191000) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 3A Inhibitors (Code: N0000190114) Neurotransmitter Agents (Code: D018377) Orexin Receptor Antagonists (Code: D000068796) Sleep Aids, Pharmaceutical (Code: D000068776) 2014-08-13 FDA 4S0V
4ZJ8
Click to view istradefylline Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL431770) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL431770) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL431770) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL431770) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL431770) selective antagonist at the A2A receptor, used in the treatment of Parkinson's disease Adenosine A2 Receptor Antagonists (Code: D058917) Neurotransmitter Agents (Code: D018377) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) 2013-03-8 PMDA
Click to view simetride a analgesic agent indicated for low back pain, symptomatic neuralgia, headache, menstrual pain, pharyngalgia/earache due to inflammation, toothache, postoperative pain, combined with caffeine 1965 PMDA
Click to view tedizolid phosphate Staphylococcus aureus subsp. aureus (Organism: None, class: Bacteria, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/21502615) Tedizolid phosphate is a prodrug that is converted by phosphatases to tedizolid, the microbiologically active moiety, following oral and intravenous administration. The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibition of protein synthesis. Tedizolid inhibits bacterial protein synthesis through a mechanism of action different from that of other non-oxazolidinone class antibacterial drugs; therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. prodrug (Code: CHEBI:50266) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Oxazolidinone Antibacterial (Code: N0000175495) Oxazolidinones (Code: N0000007568) Breast Cancer Resistance Protein Inhibitors (Code: N0000190113) 2014-06-20 FDA
Click to view dexrabeprazole Potassium-transporting ATPase (Organism: Homo sapiens, class: Transporter, accessions: P20648|P51164, gene: ATP4A|ATP4B, swissprot: ATP4A_HUMAN|ATP4B_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/2154989) None 2007-06-13 CDSCO (INDIA) 3PGL
Click to view tavaborole Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/17588934) Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) minimum inhibitory concentration (Source: http://www.ncbi.nlm.nih.gov/pubmed/17588934) Leucine--tRNA ligase, cytoplasmic (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P26637, gene: CDC60, swissprot: SYLC_YEAST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL443052) Leucine-tRNA ligase (Organism: Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892), class: Enzyme, accessions: F2SF18, gene: None, swissprot: F2SF18_TRIRC) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL443052) The mechanism of action of tavaborole is inhibition of fungal protein synthesis. Tavaborole inhibits protein synthesis by inhibition of an aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS).Tavaborole has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections. Oxaborole Antifungal (Code: N0000191279) Protein Synthesis Inhibitors (Code: N0000000150) Boron Compounds (Code: N0000008253) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) 2014-07-07 FDA
Click to view idelalisib Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Organism: Homo sapiens, class: Kinase, accessions: P48736, gene: PIK3CG, swissprot: PK3CG_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Organism: Homo sapiens, class: Kinase, accessions: P42338, gene: PIK3CB, swissprot: PK3CB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Organism: Homo sapiens, class: Kinase, accessions: P42336, gene: PIK3CA, swissprot: PK3CA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20959606) DNA-dependent protein kinase catalytic subunit (Organism: Homo sapiens, class: Kinase, accessions: P78527, gene: PRKDC, swissprot: PRKDC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2216870) Idelalisib is an inhibitor of PI3K-delta kinase, which is expressed in normal and malignant B-cells. Idelalisib induced apoptosis and inhibited proliferation in cell lines derived from malignant B-cells and in primary tumor cells. Idelalisib inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and the CXCR4 and CXCR5 signaling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Kinase Inhibitors (Code: N0000175082) Cytochrome P450 3A Inhibitors (Code: N0000190114) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) 2014-07-23 FDA 4XE0
Click to view ataluren A nonsense mutation in DNA results in a premature stop codon within an mRNA. This premature stop codon in the mRNA causes disease by terminating translation before a full-length protein is generated. Ataluren enables ribosomal readthrough of mRNA containing such a premature stop codon, resulting in production of a full-length protein. 2014-07-31 EMA
Click to view mebanazine Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/5889715) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/5889715) Mebanazine (trade name Actomol) is a monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was previously used as an antidepressant in the 1960s, but has since been discontinued.
Click to view ceritinib Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Testis-specific serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BXA7, gene: TSSK1B, swissprot: TSSK1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/23742252) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Fibroblast growth factor receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P22455, gene: FGFR4, swissprot: FGFR4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) MAP kinase-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9HBH9, gene: MKNK2, swissprot: MKNK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Cyclin-dependent kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P24941, gene: CDK2, swissprot: CDK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Transcription factor ETV6 (Organism: Homo sapiens, class: Transcription factor, accessions: P41212, gene: ETV6, swissprot: ETV6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Cyclin-dependent kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P11802, gene: CDK4, swissprot: CDK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2403108) Ceritinib is a kinase inhibitor. Targets of ceritinib inhibition identified in either biochemical or cellular assays at clinically relevant concentrations include ALK, insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (InsR), and ROS1. Among these, ceritinib is most active against ALK. Ceritinib inhibited autophosphorylation of ALK, ALK-mediated phosphorylation of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells in in vitro and in vivo assays. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Tyrosine Kinase Inhibitors (Code: N0000020001) Cytochrome P450 3A Inhibitors (Code: N0000190114) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) 2014-04-29 FDA 4MKC
Click to view umifenovir an antiviral agent 1990 Ministry of Health of the Russian Federation 5T6N
5T6S
Click to view furazidin Nitrofuran derivative anti-infective agent used for urinary tract infections. antibacterial drug (Code: CHEBI:36047) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) 2007 Ministry of Health of the Russian Federation
Click to view naloxegol Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204760s000lbl.pdf) A peripherally acting opioid receptor antagonist specific for mu-opioid receptors. Used to decrease the constipating effects of opioids. Opioid Antagonist (Code: N0000175691) Opioid Antagonists (Code: N0000000154) Central Nervous System Agents (Code: D002491) Narcotic Antagonists (Code: D009292) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2014-09-16 FDA
Click to view gemigliptin Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://professional.diabetes.org/Content/Posters/2008/p502-P.pdf) Dipeptidyl peptidase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q86TI2, gene: DPP9, swissprot: DPP9_HUMAN) None (Source: http://professional.diabetes.org/Content/Posters/2008/p502-P.pdf) Dipeptidyl Peptidase IV Inhibitors; orally active small molecule for the treatment of type II diabetes 2012-06-27 Korean Food and Drug Administration (KFDA)
Click to view eliglustat Ceramide glucosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q16739, gene: UGCG, swissprot: CEGT_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/22058426) Eliglustat tartrate is a small molecule inhibitor of glucosylceramide synthase that resembles the ceramide substrate for the enzyme. Gaucher disease is caused by a deficiency of the lysosomal enzyme acid beta-glucosidase. Acid beta-glucosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency causes an accumulation of glucosylceramide (GL-1) primarily in the lysosomal compartment of macrophages, giving rise to foam cells or "Gaucher cells". Glucosylceramide Synthase Inhibitor (Code: N0000175783) Glucosylceramide Synthase Inhibitors (Code: N0000020019) P-Glycoprotein Inhibitors (Code: N0000185503) Cytochrome P450 2D6 Inhibitors (Code: N0000182137) Enzyme Inhibitors (Code: D004791) 2014-08-19 FDA
Click to view ethacizine Ethacizine is an antiarrhythmic. Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619)
Click to view octisalate None None FDA
Click to view omarigliptin Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/24660890) Dipeptidyl peptidase 4 (Organism: Mus musculus, class: Enzyme, accessions: P28843, gene: Dpp4, swissprot: DPP4_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2105762) None 2015-09-28 PMDA
Click to view apremilast cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Organism: Homo sapiens, class: Enzyme, accessions: Q08499, gene: PDE4D, swissprot: PDE4D_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/19256507) cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7372) cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Organism: Homo sapiens, class: Enzyme, accessions: Q08493, gene: PDE4C, swissprot: PDE4C_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7372) cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Organism: Homo sapiens, class: Enzyme, accessions: Q07343, gene: PDE4B, swissprot: PDE4B_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7372) Apremilast is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action in psoriatic arthritis patients and psoriasis patients is not well defined. non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2014-03-21 FDA
Click to view empagliflozin Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 4 (Organism: Homo sapiens, class: Transporter, accessions: Q2M3M2, gene: SLC5A9, swissprot: SC5A9_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 5 (Organism: Homo sapiens, class: Transporter, accessions: A0PJK1, gene: SLC5A10, swissprot: SC5AA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/myo-inositol cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: Q8WWX8, gene: SLC5A11, swissprot: SC5AB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21985634) Empagliflozin is an inhibitor of SGLT2. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. hypoglycemic agent (Code: CHEBI:35526) Sodium-Glucose Cotransporter 2 Inhibitor (Code: N0000187059) Sodium-Glucose Transporter 2 Inhibitors (Code: N0000187058) Hypoglycemic Agents (Code: D007004) 2014-05-22 EMA
Click to view aripiprazole lauroxil D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) partial agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) partial agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207533s000lbl.pdf) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=34) prodrug of aripiprazole, following intramuscular injection is converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole which is then hydrolyzed to aripiprazole H1-receptor antagonist (Code: CHEBI:37955) second generation antipsychotic (Code: CHEBI:65191) serotonergic agonist (Code: CHEBI:35941) prodrug (Code: CHEBI:50266) Antipsychotic Agents (Code: D014150) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) 2015-10-05 FDA
Click to view amino(diphenylhydantoin) valeric acid None
Click to view meprotixol None
Click to view vintafolide has significant antiproliferative activity and tolerability, thus lending support to an ongoing phase 1 trial for the treatment of advanced malignancies. In 2014 company stopped a late-stage study (PROCEED) of vintafolide in treating ovarian cancer on the recommendation of a data safety monitoring board, saying that the drug failed to improve progression-free survival. 2012-02-09 EMA
Click to view etilefrine pivalate Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/4396765) None
Click to view laquinimod Laquinimod is an immunomodulator developed by Teva for oral treatment for multiple sclerosis. 2013-07-05 Ministry of Health of the Russian Federation
Click to view iodohippurate sodium I125 None radiopharmaceutical (Code: CHEBI:35232)
Click to view luliconazole Candida albicans (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Aspergillus fumigatus (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/10461840) Trichophyton mentagrophytes (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/9559824) Trichophyton rubrum (Organism: None, class: Fungi, accessions: None, gene: None, swissprot: None) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/9559824) Lanosterol 14-alpha demethylase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P10613, gene: ERG11, swissprot: CP51_CANAL) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2105689) an antifungal that belongs to the azole class, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase, inhibition of this enzyme's activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol Azole Antifungal (Code: N0000175487) Azoles (Code: N0000008217) Cytochrome P450 2C19 Inhibitors (Code: N0000182140) 2013-11-14 FDA
Click to view iodohippurate sodium I131 is a diagnostic aid in determining renal function, renal blood flow, ar urinary tract obstruction, and a renal imaging agent (Discontinued) radiopharmaceutical (Code: CHEBI:35232) 1968-05-24 FDA
Click to view laninamivir octanoate hydrate Neuraminidase (Organism: Influenza A virus (A/RI/5+/1957(H2N2)), class: Enzyme, accessions: Q194T1, gene: None, swissprot: Q194T1_9INFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL466246) Neuraminidase (Organism: Influenza A virus (A/WSN/1933(H1N1)), class: Enzyme, accessions: B4URF0, gene: NA, swissprot: B4URF0_9INFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL466246) an antiviral agent 2010-07-29 PMDA 3TI4
3TIB
Click to view peramivir Neuraminidase (Organism: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1), class: Enzyme, accessions: P03468, gene: NA, swissprot: NRAM_I34A1) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139367) Neuraminidase (Organism: Influenza B virus (strain B/Lee/1940), class: Enzyme, accessions: P03474, gene: NA, swissprot: NRAM_INBLE) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139367) Neuraminidase (Organism: Influenza A virus (strain A/Brevig Mission/1/1918 H1N1), class: Enzyme, accessions: Q9IGQ6, gene: NA, swissprot: NRAM_I18A0) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139367) Neuraminidase (Organism: Influenza A virus (A/WSN/1933(H1N1)), class: Enzyme, accessions: B4URF0, gene: NA, swissprot: B4URF0_9INFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL139367) Peramivir is an inhibitor of influenza virus neuraminidase, an enzyme that releases viral particles from the plasma membrane of infected cells. EC 3.2.1.18 (exo-alpha-sialidase) inhibitor (Code: CHEBI:52425) antiviral drug (Code: CHEBI:36044) Neuraminidase Inhibitor (Code: N0000175524) Neuraminidase Inhibitors (Code: N0000175436) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) 2014-12-19 FDA 1L7F
1L7G
1L7H
2F10
2HTU
3K37
3K39
4MWV
4MX0
Click to view florbetaben F18 Amyloid beta A4 protein (Organism: Homo sapiens, class: Unclassified, accessions: P05067, gene: APP, swissprot: A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL566752) Florbetaben F18 is a F18-labeled stilbene derivative, which binds to beta-amyloid plaques in the brain. The F 18 isotope produces a positron signal that is detected by a PET scanner. Radioactive Diagnostic Agent (Code: N0000177914) Positron Emitting Activity (Code: N0000175869) 2014-03-19 FDA
Click to view delamanid an antitubercular agent 2014-04-28 EMA
Click to view nordefrin Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL677) A norepinephrine derivative used as a vasoconstrictor agent. Cardiovascular Agents (Code: D002317) Vasoconstrictor Agents (Code: D014662)
Click to view tasimelteon Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22640220) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22640220) an agonist at melatonin MT1 and MT2 receptors, these receptors are thought to be involved in the control of circadian rhythms Melatonin Receptor Agonist (Code: N0000175743) Melatonin Receptor Agonists (Code: N0000000250) 2014-01-31 FDA
Click to view rifamycin Bile salt export pump (Organism: Homo sapiens, class: Transporter, accessions: O95342, gene: ABCB11, swissprot: ABCBB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL437765) Bile salt export pump (Organism: Rattus norvegicus, class: Unclassified, accessions: O70127, gene: Abcb11, swissprot: ABCBB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL437765) Solute carrier organic anion transporter family member 1A2 (Organism: Homo sapiens, class: Unclassified, accessions: P46721, gene: SLCO1A2, swissprot: SO1A2_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4570) Solute carrier organic anion transporter family member 1B1 (Organism: Homo sapiens, class: Transporter, accessions: Q9Y6L6, gene: SLCO1B1, swissprot: SO1B1_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4570) None antitubercular agent (Code: CHEBI:33231) Antirheumatic Agents (Code: D018501) 1988-10-03 Swissmedic (Switzerland)
Click to view olodaterol Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/20371707) a long-acting beta2-adrenergic agonist (LABA), activation of beta2 receptors in the airways results in a stimulation of intracellular adenyl cyclase, an enzyme that mediates the synthesis of cyclic-3',5' adenosine monophosphate (cAMP), elevated levels of cAMP induce bronchodilation by relaxation of airway smooth muscle cells beta-adrenergic agonist (Code: CHEBI:35522) bronchodilator agent (Code: CHEBI:35523) beta2-Adrenergic Agonist (Code: N0000175779) Adrenergic beta2-Agonists (Code: N0000009922) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) 2014-07-31 FDA
Click to view umeclidinium Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19317446) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7354) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7354) a long-acting antimuscarinic agent with similar affinity to the subtypes of muscarinic receptors M1 to M5, in the airways, it exhibits pharmacological effects through inhibition of M3 receptor at the smooth muscle leading to bronchodilation muscarinic antagonist (Code: CHEBI:48876) Anticholinergic (Code: N0000175574) Cholinergic Antagonists (Code: N0000175370) 2013-12-18 FDA
Click to view vortioxetine 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 1B (Organism: Homo sapiens, class: GPCR, accessions: P28222, gene: HTR1B, swissprot: 5HT1B_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21486038) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/22171087) 5-hydroxytryptamine receptor 1D (Organism: Homo sapiens, class: GPCR, accessions: P28221, gene: HTR1D, swissprot: 5HT1D_HUMAN) antagonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204447s004lbl.pdf) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 3A (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563, gene: Htr3a, swissprot: 5HT3A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 5A (Organism: Homo sapiens, class: GPCR, accessions: P47898, gene: HTR5A, swissprot: 5HT5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: P50406, gene: HTR6, swissprot: 5HT6R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104993) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7351) an anti-anxiety agent, 5-HT1A receptor agonist, 5-HT3 receptor antagonist, and 5-HT7 receptor antagonist antidepressant (Code: CHEBI:35469) anxiolytic drug (Code: CHEBI:35474) serotonergic agonist (Code: CHEBI:35941) serotonergic antagonist (Code: CHEBI:48279) Anti-Anxiety Agents (Code: D014151) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin 5-HT1 Receptor Antagonists (Code: D058829) Serotonin 5-HT3 Receptor Antagonists (Code: D058831) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702) Serotonin Receptor Agonists (Code: D017366) Serotonin Uptake Inhibitors (Code: D017367) Tranquilizing Agents (Code: D014149) 2013-09-30 FDA
Click to view riociguat Guanylate cyclase soluble subunit beta-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q02153, gene: GUCY1B3, swissprot: GCYB1_HUMAN) positive allosteric modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/19263460) cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Organism: Homo sapiens, class: Enzyme, accessions: Q9NP56, gene: PDE7B, swissprot: PDE7B_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/19263460) guanylate cyclase stimulator antihypertensive agent (Code: CHEBI:35674) Guanylate Cyclase Stimulators (Code: N0000190484) Soluble Guanylate Cyclase Stimulator (Code: N0000190485) Enzyme Activators (Code: D020536) 2013-10-08 FDA
Click to view sofosbuvir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/20845908) NS5B protein (Organism: Hepatitis C virus, class: Enzyme, accessions: Q8JXU8, gene: NS5B, swissprot: Q8JXU8_9HEPC) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1259059) Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator prodrug (Code: CHEBI:50266) antiviral drug (Code: CHEBI:36044) Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor (Code: N0000191493) RNA Replicase Inhibitors (Code: N0000191258) Nucleoside Analog (Code: N0000175459) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) 2013-12-06 FDA
Click to view simeprevir Genome polyprotein (Organism: Hepatitis C virus genotype 1a (isolate H), class: Polyprotein, accessions: P27958, gene: None, swissprot: POLG_HCVH) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/205123s008lbl.pdf) Cathepsin S (Organism: Homo sapiens, class: Enzyme, accessions: P25774, gene: CTSS, swissprot: CATS_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL501849) Hepatitis C virus serine protease, NS3/NS4A (Organism: Hepatitis C virus, class: Enzyme, accessions: A3EZI9|D2K2A8, gene: NS3|NS4A, swissprot: A3EZI9_9HEPC|D2K2A8_9HEPC) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL501849) Nonstructural protein NS3-4A (Organism: Hepatitis C virus, class: Unclassified, accessions: A0A0K1CY61, gene: None, swissprot: A0A0K1CY61_9HEPC) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL501849) Polyprotein (Organism: Hepacivirus C, class: Polyprotein, accessions: Q6GYR8, gene: None, swissprot: Q6GYR8_9HEPC) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7367) Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. Hepatitis C Virus NS3/4A Protease Inhibitor (Code: N0000182639) HCV NS3/4A Protease Inhibitors (Code: N0000182638) Cytochrome P450 3A4 Inhibitors (Code: N0000182141) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Anion Transporting Polypeptide 1B1 Inhibitors (Code: N0000190107) Organic Anion Transporting Polypeptide 1B3 Inhibitors (Code: N0000190108) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Protease Inhibitors (Code: D011480) 2013-11-22 FDA 3KEE
Click to view ipidacrine Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/11256231) Butyrylcholinesterase; Protein Bche (Organism: Rattus norvegicus, class: Enzyme, accessions: Q9JKC1, gene: Bche, swissprot: Q9JKC1_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/11256231) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL130880) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL130880) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL130880) do not confuse with neuromedin None Ministry of Health of the Russian Federation
Click to view macitentan Endothelin-1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25101, gene: EDNRA, swissprot: EDNRA_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22862294) Endothelin B receptor (Organism: Homo sapiens, class: GPCR, accessions: P24530, gene: EDNRB, swissprot: EDNRB_HUMAN) antagonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22862294) an endothelin receptor antagonist that prevents the binding of ET-1 to both ETA and ETB receptors, macitentan displays high affinity and sustained occupancy of the ET receptors in human pulmonary arterial smooth muscle cells endothelin receptor antagonist (Code: CHEBI:51451) antihypertensive agent (Code: CHEBI:35674) orphan drug (Code: CHEBI:71031) Endothelin A Receptor Antagonists (Code: D065130) Endothelin B Receptor Antagonists (Code: D065131) Endothelin Receptor Antagonists (Code: D065128) 2013-10-18 FDA
Click to view ibrutinib Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17154430) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/17154430) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1873475) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1873475) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1873475) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1873475) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase HCK (Organism: Homo sapiens, class: Kinase, accessions: P08631, gene: HCK, swissprot: HCK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase Tec (Organism: Homo sapiens, class: Kinase, accessions: P42680, gene: TEC, swissprot: TEC_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-2 (Organism: Homo sapiens, class: Kinase, accessions: P04626, gene: ERBB2, swissprot: ERBB2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Receptor tyrosine-protein kinase erbB-4 (Organism: Homo sapiens, class: Kinase, accessions: Q15303, gene: ERBB4, swissprot: ERBB4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/26641137) Ibrutinib is a small-molecule inhibitor of BTK. Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. BTK's role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. Nonclinical studies show that ibrutinib inhibits malignant B-cell proliferation and survival in vivo as well as cell migration and substrate adhesion in vitro. antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) 2013-11-13 FDA 4IFG
4RZ7
5P9I
5YU9
5P9J
Click to view dolutegravir Sigma non-opioid intracellular receptor 1 (Organism: Cavia porcellus, class: Membrane other, accessions: Q60492, gene: SIGMAR1, swissprot: SGMR1_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1213165) Integrase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q7ZJM1, gene: pol, swissprot: Q7ZJM1_9HIV1) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/27645238) Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral deoxyribonucleic acid (DNA) integration which is essential for the HIV replication cycle. Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor (Code: N0000175887) Multidrug and Toxin Extrusion Transporter 1 Inhibitors (Code: N0000191423) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) Anti-HIV Agents (Code: D019380) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) HIV Integrase Inhibitors (Code: D019428) 2013-08-12 FDA 3S3M
3S3N
3S3O
Click to view dimethyl fumarate Kelch-like ECH-associated protein 1 (Organism: Homo sapiens, class: Cytosolic other, accessions: Q14145, gene: KEAP1, swissprot: KEAP1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL589586) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL589586) A fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS. immunomodulator (Code: CHEBI:50846) antipsoriatic (Code: CHEBI:50748) Dermatologic Agents (Code: D003879) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Radiation-Sensitizing Agents (Code: D011838) 2013-03-27 FDA
Click to view canagliflozin Sodium/glucose cotransporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P31639, gene: SLC5A2, swissprot: SC5A2_HUMAN) inhibitor (Source: WOMBAT-PK) Sodium/glucose cotransporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P13866, gene: SLC5A1, swissprot: SC5A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2048484) Protease (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9YQ12, gene: protease, swissprot: Q9YQ12_9HIV1) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2048484) A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. hypoglycemic agent (Code: CHEBI:35526) Sodium-Glucose Cotransporter 2 Inhibitor (Code: N0000187059) Sodium-Glucose Transporter 2 Inhibitors (Code: N0000187058) P-Glycoprotein Inhibitors (Code: N0000185503) Hypoglycemic Agents (Code: D007004) 2013-03-29 FDA
Click to view glycerol phenylbutyrate glutamine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/203284s001lbl.pdf) for treating urea cycle disorders 2013-02-01 FDA
Click to view pomalidomide Protein cereblon (Organism: Homo sapiens, class: Cytosolic other, accessions: Q96SW2, gene: CRBN, swissprot: CRBN_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/26131937) an immunomodulator with antineoplastic and angiogenesis inhibitor activity angiogenesis inhibitor (Code: CHEBI:48422) antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) Angiogenesis Inhibitors (Code: D020533) Angiogenesis Modulating Agents (Code: D043924) Antineoplastic Agents (Code: D000970) Growth Inhibitors (Code: D006131) Growth Substances (Code: D006133) Immunologic Factors (Code: D007155) Thalidomide Analog (Code: N0000184014) 2013-02-08 FDA 4CI3
4TZU
4V2Z
Click to view quifenadine blocks histamine H1-receptors in the peripheral tissues, and activates enzyme diaminoxidase (histaminase), due to this decreasing the histamine concentration in tissues Histamine Agents (Code: D018494) Histamine Antagonists (Code: D006633) Neurotransmitter Agents (Code: D018377) 2006-02-17 Ministry of Health of the Russian Federation
Click to view ospemifene Estrogen receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P03372, gene: ESR1, swissprot: ESR1_HUMAN) modulator (Source: WOMBAT-PK) an estrogen agonist/antagonist with tissue selective effects, its biological actions are mediated through binding to estrogen receptors, this binding results in activation of estrogenic pathways in some tissues (agonism) and blockade of estrogenic pathways in others (antagonism) estrogen receptor modulator (Code: CHEBI:50739) antineoplastic agent (Code: CHEBI:35610) anti-inflammatory agent (Code: CHEBI:67079) Estrogen Agonist/Antagonist (Code: N0000175826) Selective Estrogen Receptor Modulators (Code: N0000000168) 2013-02-26 FDA
Click to view cetyl alcohol has been used for eczema, skin irritations; RN given refers to parent cpd; structure 1990-08-02 FDA 2UUU
2UUV
4QUW
4RC5
4RC7
Click to view levobetaxolol Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8035) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8035) a cardioselective (beta-1-adrenergic) receptor blocking agent that does not have significant membrane-stabilizing (local anesthetic) activity and is devoid of intrinsic sympathomimetic action 2000-02-23 FDA
Click to view regorafenib Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5891) Serine/threonine-protein kinase B-raf (Organism: Homo sapiens, class: Kinase, accessions: P15056, gene: BRAF, swissprot: BRAF_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1946170) Bifunctional epoxide hydrolase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P34913, gene: EPHX2, swissprot: HYES_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1946170) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1946170) a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and in pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Protein Kinase Inhibitors (Code: N0000175076) Cytochrome P450 2C9 Inhibitors (Code: N0000185504) 2012-09-27 FDA
Click to view tedisamil Potassium voltage-gated channel subfamily A member 7 (Organism: Mus musculus, class: Unclassified, accessions: Q17ST2, gene: Kcna7, swissprot: KCNA7_MOUSE) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2567) a multiple potassium channel blocker which blocks the rapid (IKr), slow (IKs) and ultrarapid (IKur) components of the delayed rectifier potassium current, the transient outward potassium current (Ito) and the ATP (IKATP) sensitive and the acetylcholine-activated (IKACH) potassium currents Anti-Arrhythmia Agents (Code: D000889) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Protective Agents (Code: D020011) 2008-05-21 UK Medicines and Healthcare Products Regulatory Agency (MHRA)
Click to view metabutethamine None
Click to view metamizole Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/25765567) A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE prodrug (Code: CHEBI:50266) non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) peripheral nervous system drug (Code: CHEBI:49110) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antipyretics (Code: D058633) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1949-05-10 Swissmedic (Switzerland)
Click to view methylatropine Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL516476) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL516476) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL516476) Muscarinic acetylcholine receptor DM1 (Organism: Drosophila melanogaster, class: GPCR, accessions: P16395, gene: mAChR-A, swissprot: ACM1_DROME) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL516476) None Autonomic Agents (Code: D001337) Parasympatholytics (Code: D010276) Peripheral Nervous System Agents (Code: D018373)
Click to view creatine An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine. None FDA 1V7Z
3A6J
3B6R
Click to view benzoin Cocaine esterase (Organism: Homo sapiens, class: Enzyme, accessions: O00748, gene: CES2, swissprot: EST2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190677) Liver carboxylesterase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23141, gene: CES1, swissprot: EST1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190677) A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX. None FDA
Click to view octinoxate a UV filter compound 1992-12-07 FDA
Click to view avobenzone Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200522) causes allergic or photoallergic contact dermatitis; structure given in first source Cosmetics (Code: D003358) Dermatologic Agents (Code: D003879) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Sunscreening Agents (Code: D013473) 1992-12-07 FDA
Click to view methyl salicylate used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990 flavouring agent (Code: CHEBI:35617) insect attractant (Code: CHEBI:24850) Antirheumatic Agents (Code: D018501) Fixatives (Code: D005404) 2008-02-20 FDA
Click to view tafluprost Prostaglandin F2-alpha receptor (Organism: Homo sapiens, class: GPCR, accessions: P43088, gene: PTGFR, swissprot: PF2R_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1963683) a prostaglandin analog is a selective FP prostanoid receptor agonist which is believed to reduce intraocular pressure by increasing uveoscleral outflow Prostaglandin Analog (Code: N0000175454) Prostaglandin Receptor Agonists (Code: N0000000106) Increased Prostaglandin Activity (Code: N0000009526) Prostaglandins (Code: N0000007706) 2012-02-10 FDA
Click to view Ioflupane I-123 a radiopharmaceutical indicated for striatal dopamine transporter visualization using single photon emission computed tomography (SPECT) brain imaging to assist in the evaluation of adult patients with suspected Parkinsonian syndromes (PS) radiopharmaceutical (Code: CHEBI:35232) Radioactive Diagnostic Agent (Code: N0000177914) Radiopharmaceutical Activity (Code: N0000000205) 2011-01-14 FDA
Click to view telbivudine Protein P (Organism: Hepatitis B virus, class: Polyprotein, accessions: Q9IF40, gene: P, swissprot: Q9IF40_HBV) inhibitor (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022011s013lbl.pdf) has an activity against hepatitis B virus antiviral drug (Code: CHEBI:36044) Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor (Code: N0000175656) Nucleoside Analog (Code: N0000175459) Nucleoside Reverse Transcriptase Inhibitors (Code: N0000009947) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) 2006-10-25 FDA 3HP1
3QEO
Click to view formaldehyde A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) Anti-Infective Agents (Code: D000890) Disinfectants (Code: D004202) Fixatives (Code: D005404) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) None FDA
Click to view mequinol Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL544) a substrate for the enzyme tyrosinase and acts as a competitive inhibitor of the formation of melanin precursors, depigmenting agent; RN given refers to parent cpd Antineoplastic Agents (Code: D000970) Antioxidants (Code: D000975) Protective Agents (Code: D020011) Depigmenting Activity (Code: N0000175851) Melanin Synthesis Inhibitors (Code: N0000175850) Skin Lightening Agent (Code: N0000175855) 1999-12-10 FDA 4Z3G
4Z3H
5K1M
Click to view vilazodone Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) 5-hydroxytryptamine receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q13639, gene: HTR4, swissprot: 5HT4R_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7427) 5-hydroxytryptamine receptor 7 (Organism: Rattus norvegicus, class: GPCR, accessions: P32305, gene: Htr7, swissprot: 5HT7R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) Serotonin 3 (5-HT3) receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35563|Q9JJ16, gene: Htr3a|Htr3b, swissprot: 5HT3A_RAT|5HT3B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 2C (Organism: Rattus norvegicus, class: GPCR, accessions: P08909, gene: Htr2c, swissprot: 5HT2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 2A (Organism: Rattus norvegicus, class: GPCR, accessions: P14842, gene: Htr2a, swissprot: 5HT2A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P31388, gene: Htr6, swissprot: 5HT6R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 1B (Organism: Rattus norvegicus, class: GPCR, accessions: P28564, gene: Htr1b, swissprot: 5HT1B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 1A (Organism: Rattus norvegicus, class: GPCR, accessions: P19327, gene: Htr1a, swissprot: 5HT1A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 1D (Organism: Rattus norvegicus, class: GPCR, accessions: P28565, gene: Htr1d, swissprot: 5HT1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) Adrenergic receptor alpha-1 (Organism: Homo sapiens, class: GPCR, accessions: P25100|P35348|P35368, gene: ADRA1A|ADRA1B|ADRA1D, swissprot: ADA1A_HUMAN|ADA1B_HUMAN|ADA1D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) 5-hydroxytryptamine receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: Q62758, gene: Htr4, swissprot: 5HT4R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL439849) A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT. antidepressant (Code: CHEBI:35469) serotonergic agonist (Code: CHEBI:35941) serotonin uptake inhibitor (Code: CHEBI:50949) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619) Serotonin 5-HT1 Receptor Agonists (Code: D058825) Serotonin Agents (Code: D018490) Serotonin Receptor Agonists (Code: D017366) Serotonin Uptake Inhibitors (Code: D017367) 2011-01-21 FDA
Click to view pirfenidone pyridone, indicated for the treatment of idiopathic pulmonary fibrosis non-narcotic analgesic (Code: CHEBI:35481) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) antipyretic (Code: CHEBI:35493) Pyridone (Code: N0000191420) Pyridones (Code: N0000007575) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antineoplastic Agents (Code: D000970) Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2008-09-16 PMDA
Click to view axitinib SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: P53779, gene: MAPK10, swissprot: MK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Dual specificity mitogen-activated protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q02750, gene: MAP2K1, swissprot: MP2K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Vascular endothelial growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P35968, gene: KDR, swissprot: VGFR2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Platelet-derived growth factor receptor alpha (Organism: Homo sapiens, class: Kinase, accessions: P16234, gene: PDGFRA, swissprot: PGFRA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Cyclin-G-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: O14976, gene: GAK, swissprot: GAK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Dual specificity mitogen-activated protein kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q13163, gene: MAP2K5, swissprot: MP2K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase MLT (Organism: Homo sapiens, class: Kinase, accessions: Q9NYL2, gene: ZAK, swissprot: MLTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Dual specificity protein kinase TTK (Organism: Homo sapiens, class: Kinase, accessions: P33981, gene: TTK, swissprot: TTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: O75716, gene: STK16, swissprot: STK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Casein kinase II subunit alpha' (Organism: Homo sapiens, class: Kinase, accessions: P19784, gene: CSNK2A2, swissprot: CSK22_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase N2 (Organism: Homo sapiens, class: Kinase, accessions: Q16513, gene: PKN2, swissprot: PKN2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase CSK (Organism: Homo sapiens, class: Kinase, accessions: P41240, gene: CSK, swissprot: CSK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Platelet-derived growth factor receptor beta (Organism: Homo sapiens, class: Kinase, accessions: P09619, gene: PDGFRB, swissprot: PGFRB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Fibroblast growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P11362, gene: FGFR1, swissprot: FGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Fibroblast growth factor receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P21802, gene: FGFR2, swissprot: FGFR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Myosin-IIIa (Organism: Homo sapiens, class: Kinase, accessions: Q8NEV4, gene: MYO3A, swissprot: MYO3A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase 8 (Organism: Homo sapiens, class: Kinase, accessions: P45983, gene: MAPK8, swissprot: MK08_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y6R4, gene: MAP3K4, swissprot: M3K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Leucine-rich repeat serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q5S007, gene: LRRK2, swissprot: LRRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) TRAF2 and NCK-interacting protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9UKE5, gene: TNIK, swissprot: TNIK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Calcium/calmodulin-dependent protein kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N5S9, gene: CAMKK1, swissprot: KKCC1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Cyclin-dependent kinase 16 (Organism: Homo sapiens, class: Kinase, accessions: Q00536, gene: CDK16, swissprot: CDK16_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase MRCK beta (Organism: Homo sapiens, class: Kinase, accessions: Q9Y5S2, gene: CDC42BPB, swissprot: MRCKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Activin receptor type-2B (Organism: Homo sapiens, class: Kinase, accessions: Q13705, gene: ACVR2B, swissprot: AVR2B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Vascular endothelial growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P35916, gene: FLT4, swissprot: VGFR3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Hormonally up-regulated neu tumor-associated kinase (Organism: Homo sapiens, class: Kinase, accessions: P57058, gene: HUNK, swissprot: HUNK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Discoidin domain-containing receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: Q16832, gene: DDR2, swissprot: DDR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase PAK 4 (Organism: Homo sapiens, class: Kinase, accessions: O96013, gene: PAK4, swissprot: PAK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: O95819, gene: MAP4K4, swissprot: M4K4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Myosin light chain kinase 2, skeletal/cardiac muscle (Organism: Homo sapiens, class: Kinase, accessions: Q9H1R3, gene: MYLK2, swissprot: MYLK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase 9 (Organism: Homo sapiens, class: Kinase, accessions: P80192, gene: MAP3K9, swissprot: M3K9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Dual specificity mitogen-activated protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P36507, gene: MAP2K2, swissprot: MP2K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Myosin light chain kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q32MK0, gene: MYLK3, swissprot: MYLK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Serine/threonine-protein kinase SIK1 (Organism: Homo sapiens, class: Kinase, accessions: P57059, gene: SIK1, swissprot: SIK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1289926) oral Angiogenesis Inhibitor that inhibits the tyrosine kinase activities of both VEGFR and PDGFRbeta antineoplastic agent (Code: CHEBI:35610) Kinase Inhibitor (Code: N0000175605) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) 2012-01-27 FDA 4AG8
4AGC
4TWP
4WA9
Click to view ingenol mebutate Protein kinase C delta type (Organism: Homo sapiens, class: Kinase, accessions: Q05655, gene: PRKCD, swissprot: KPCD_HUMAN) activator (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C alpha type (Organism: Homo sapiens, class: Kinase, accessions: P17252, gene: PRKCA, swissprot: KPCA_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C beta type (Organism: Homo sapiens, class: Kinase, accessions: P05771, gene: PRKCB, swissprot: KPCB_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C epsilon type (Organism: Homo sapiens, class: Kinase, accessions: Q02156, gene: PRKCE, swissprot: KPCE_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/15126366) Protein kinase C gamma type (Organism: Homo sapiens, class: Kinase, accessions: P05129, gene: PRKCG, swissprot: KPCG_HUMAN) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7443) protein kinase C agonist and antineoplastic antineoplastic agent (Code: CHEBI:35610) Cell Death Inducer (Code: N0000184015) Increased Cellular Death (Code: N0000009176) 2012-01-23 FDA
Click to view icatibant B1 bradykinin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P97583, gene: Bdkrb1, swissprot: BKRB1_RAT) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=667) B1 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P46663, gene: BDKRB1, swissprot: BKRB1_HUMAN) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=667) B2 bradykinin receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25023, gene: Bdkrb2, swissprot: BKRB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2028850) B2 bradykinin receptor (Organism: Cavia porcellus, class: GPCR, accessions: O70526, gene: BDKRB2, swissprot: BKRB2_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2028850) B2 bradykinin receptor (Organism: Homo sapiens, class: GPCR, accessions: P30411, gene: BDKRB2, swissprot: BKRB2_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2028850) B2 bradykinin receptor (Organism: Mus musculus, class: Unclassified, accessions: P32299, gene: Bdkrb2, swissprot: BKRB2_MOUSE) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=667) a potent bradykinin (B2) receptor antagonist; WIN 65365 is an L-Tic(7) stereoisomer beta-adrenergic antagonist (Code: CHEBI:35530) Bradykinin B2 Receptor Antagonist (Code: N0000182965) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Bradykinin B2 Receptor Antagonists (Code: D065094) Bradykinin Receptor Antagonists (Code: D065168) Complement Inactivating Agents (Code: D051056) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2008-07-11 EMA
Click to view crizotinib Receptor-type tyrosine-protein kinase FLT3 (Organism: Homo sapiens, class: Kinase, accessions: P36888, gene: FLT3, swissprot: FLT3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Cyclin-dependent kinase-like 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92772, gene: CDKL2, swissprot: CDKL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase ABL1 (Organism: Homo sapiens, class: Kinase, accessions: P00519, gene: ABL1, swissprot: ABL1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Epidermal growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P00533, gene: EGFR, swissprot: EGFR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase DCLK1 (Organism: Homo sapiens, class: Kinase, accessions: O15075, gene: DCLK1, swissprot: DCLK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Muscle, skeletal receptor tyrosine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: O15146, gene: MUSK, swissprot: MUSK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Vascular endothelial growth factor receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P17948, gene: FLT1, swissprot: VGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Proto-oncogene tyrosine-protein kinase Src (Organism: Homo sapiens, class: Kinase, accessions: P12931, gene: SRC, swissprot: SRC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Fibroblast growth factor receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P22607, gene: FGFR3, swissprot: FGFR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase 35 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDR2, gene: STK35, swissprot: STK35_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Insulin receptor (Organism: Homo sapiens, class: Kinase, accessions: P06213, gene: INSR, swissprot: INSR_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) SRSF protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q96SB4, gene: SRPK1, swissprot: SRPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q92630, gene: DYRK2, swissprot: DYRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase RIO3 (Organism: Homo sapiens, class: Kinase, accessions: O14730, gene: RIOK3, swissprot: RIOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Hepatocyte growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P08581, gene: MET, swissprot: MET_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Dual specificity mitogen-activated protein kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P46734, gene: MAP2K3, swissprot: MP2K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Receptor-interacting serine/threonine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O43353, gene: RIPK2, swissprot: RIPK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-B receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54760, gene: EPHB4, swissprot: EPHB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase JAK2 (Organism: Homo sapiens, class: Kinase, accessions: O60674, gene: JAK2, swissprot: JAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase NIM1 (Organism: Homo sapiens, class: Kinase, accessions: Q8IY84, gene: NIM1K, swissprot: NIM1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase SBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q52WX2, gene: SBK1, swissprot: SBK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 15 (Organism: Homo sapiens, class: Kinase, accessions: Q6ZN16, gene: MAP3K15, swissprot: M3K15_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Aurora kinase A (Organism: Homo sapiens, class: Kinase, accessions: O14965, gene: AURKA, swissprot: AURKA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase JAK1 (Organism: Homo sapiens, class: Kinase, accessions: P23458, gene: JAK1, swissprot: JAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase ITK/TSK (Organism: Homo sapiens, class: Kinase, accessions: Q08881, gene: ITK, swissprot: ITK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase SYK (Organism: Homo sapiens, class: Kinase, accessions: P43405, gene: SYK, swissprot: KSYK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Interferon-induced, double-stranded RNA-activated protein kinase (Organism: Homo sapiens, class: Kinase, accessions: P19525, gene: EIF2AK2, swissprot: E2AK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase BTK (Organism: Homo sapiens, class: Kinase, accessions: Q06187, gene: BTK, swissprot: BTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Cyclin-dependent kinase 11B (Organism: Homo sapiens, class: Kinase, accessions: P21127, gene: CDK11B, swissprot: CD11B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase D1 (Organism: Homo sapiens, class: Kinase, accessions: Q15139, gene: PRKD1, swissprot: KPCD1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 13 (Organism: Homo sapiens, class: Kinase, accessions: O43283, gene: MAP3K13, swissprot: M3K13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase TBK1 (Organism: Homo sapiens, class: Kinase, accessions: Q9UHD2, gene: TBK1, swissprot: TBK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P21709, gene: EPHA1, swissprot: EPHA1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase Nek7 (Organism: Homo sapiens, class: Kinase, accessions: Q8TDX7, gene: NEK7, swissprot: NEK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q92918, gene: MAP4K1, swissprot: M4K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) AarF domain-containing protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q96D53, gene: COQ8B, swissprot: COQ8B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Fgr (Organism: Homo sapiens, class: Kinase, accessions: P09769, gene: FGR, swissprot: FGR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase D3 (Organism: Homo sapiens, class: Kinase, accessions: O94806, gene: PRKD3, swissprot: KPCD3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Angiopoietin-1 receptor (Organism: Mus musculus, class: Kinase, accessions: Q02858, gene: Tek, swissprot: TIE2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: O43318, gene: MAP3K7, swissprot: M3K7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase FRK (Organism: Homo sapiens, class: Kinase, accessions: P42685, gene: FRK, swissprot: FRK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 8 (Organism: Homo sapiens, class: Kinase, accessions: P29322, gene: EPHA8, swissprot: EPHA8_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 2 (Organism: Homo sapiens, class: Kinase, accessions: P29317, gene: EPHA2, swissprot: EPHA2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 3 (Organism: Homo sapiens, class: Kinase, accessions: P29320, gene: EPHA3, swissprot: EPHA3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase 10 (Organism: Homo sapiens, class: Kinase, accessions: O94804, gene: STK10, swissprot: STK10_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Fer (Organism: Homo sapiens, class: Kinase, accessions: P16591, gene: FER, swissprot: FER_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase PLK4 (Organism: Homo sapiens, class: Kinase, accessions: O00444, gene: PLK4, swissprot: PLK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) AP2-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q2M2I8, gene: AAK1, swissprot: AAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase JAK3 (Organism: Homo sapiens, class: Kinase, accessions: P52333, gene: JAK3, swissprot: JAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Yes (Organism: Homo sapiens, class: Kinase, accessions: P07947, gene: YES1, swissprot: YES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase ABL1 (Organism: Mus musculus, class: Kinase, accessions: P00520, gene: Abl1, swissprot: ABL1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase TAO1 (Organism: Homo sapiens, class: Kinase, accessions: Q7L7X3, gene: TAOK1, swissprot: TAOK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase TNNI3K (Organism: Homo sapiens, class: Kinase, accessions: Q59H18, gene: TNNI3K, swissprot: TNI3K_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Aurora kinase C (Organism: Homo sapiens, class: Kinase, accessions: Q9UQB9, gene: AURKC, swissprot: AURKC_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) High affinity nerve growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: P04629, gene: NTRK1, swissprot: NTRK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Rho-associated protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13464, gene: ROCK1, swissprot: ROCK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ankyrin repeat and protein kinase domain-containing protein 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8NFD2, gene: ANKK1, swissprot: ANKK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Homeodomain-interacting protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q8NE63, gene: HIPK4, swissprot: HIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase kinase 5 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y4K4, gene: MAP4K5, swissprot: M4K5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase DCLK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8N568, gene: DCLK2, swissprot: DCLK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Misshapen-like kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q8N4C8, gene: MINK1, swissprot: MINK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Interleukin-1 receptor-associated kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q9NWZ3, gene: IRAK4, swissprot: IRAK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Insulin receptor-related protein (Organism: Homo sapiens, class: Kinase, accessions: P14616, gene: INSRR, swissprot: INSRR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mast/stem cell growth factor receptor Kit (Organism: Homo sapiens, class: Kinase, accessions: P10721, gene: KIT, swissprot: KIT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) BMP-2-inducible protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9NSY1, gene: BMP2K, swissprot: BMP2K_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Insulin-like growth factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P08069, gene: IGF1R, swissprot: IGF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: Q9UF33, gene: EPHA6, swissprot: EPHA6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Calcium/calmodulin-dependent protein kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q96RR4, gene: CAMKK2, swissprot: KKCC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Aurora kinase B (Organism: Homo sapiens, class: Kinase, accessions: Q96GD4, gene: AURKB, swissprot: AURKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) STE20-like serine/threonine-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q9H2G2, gene: SLK, swissprot: SLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Bone morphogenetic protein receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: O00238, gene: BMPR1B, swissprot: BMR1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Macrophage-stimulating protein receptor (Organism: Homo sapiens, class: Kinase, accessions: Q04912, gene: MST1R, swissprot: RON_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Non-receptor tyrosine-protein kinase TYK2 (Organism: Homo sapiens, class: Kinase, accessions: P29597, gene: TYK2, swissprot: TYK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Interleukin-1 receptor-associated kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P51617, gene: IRAK1, swissprot: IRAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: Q13043, gene: STK4, swissprot: STK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 7 (Organism: Homo sapiens, class: Kinase, accessions: Q15375, gene: EPHA7, swissprot: EPHA7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q13188, gene: STK3, swissprot: STK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Inhibitor of nuclear factor kappa-B kinase subunit beta (Organism: Homo sapiens, class: Kinase, accessions: O14920, gene: IKBKB, swissprot: IKKB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase Nek9 (Organism: Homo sapiens, class: Kinase, accessions: Q8TD19, gene: NEK9, swissprot: NEK9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase TAO2 (Organism: Homo sapiens, class: Kinase, accessions: Q9UL54, gene: TAOK2, swissprot: TAOK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Lyn (Organism: Homo sapiens, class: Kinase, accessions: P07948, gene: LYN, swissprot: LYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (Organism: Homo sapiens, class: Kinase, accessions: Q13131, gene: PRKAA1, swissprot: AAPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Cytoplasmic tyrosine-protein kinase BMX (Organism: Homo sapiens, class: Kinase, accessions: P51813, gene: BMX, swissprot: BMX_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 5 (Organism: Homo sapiens, class: Kinase, accessions: P54756, gene: EPHA5, swissprot: EPHA5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) LIM domain kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: P53667, gene: LIMK1, swissprot: LIMK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) (Organism: Homo sapiens, class: Kinase, accessions: P06748|Q9UM73, gene: ALK|NPM1, swissprot: ALK_HUMAN|NPM_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase ULK2 (Organism: Homo sapiens, class: Kinase, accessions: Q8IYT8, gene: ULK2, swissprot: ULK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-A receptor 4 (Organism: Homo sapiens, class: Kinase, accessions: P54764, gene: EPHA4, swissprot: EPHA4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-B receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: P54762, gene: EPHB1, swissprot: EPHB1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Activated CDC42 kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q07912, gene: TNK2, swissprot: ACK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q8IVH8, gene: MAP4K3, swissprot: M4K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Dual specificity testis-specific protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q15569, gene: TESK1, swissprot: TESK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Focal adhesion kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q05397, gene: PTK2, swissprot: FAK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) NT-3 growth factor receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16288, gene: NTRK3, swissprot: NTRK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase ZAP-70 (Organism: Homo sapiens, class: Kinase, accessions: P43403, gene: ZAP70, swissprot: ZAP70_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Activin receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: Q04771, gene: ACVR1, swissprot: ACVR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Interleukin-1 receptor-associated kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y616, gene: IRAK3, swissprot: IRAK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) G protein-coupled receptor kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P32298, gene: GRK4, swissprot: GRK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y2U5, gene: MAP3K2, swissprot: M3K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase ULK3 (Organism: Homo sapiens, class: Kinase, accessions: Q6PHR2, gene: ULK3, swissprot: ULK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Abelson tyrosine-protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P42684, gene: ABL2, swissprot: ABL2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase 26 (Organism: Homo sapiens, class: Kinase, accessions: Q9P289, gene: STK26, swissprot: STK26_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Protein-tyrosine kinase 2-beta (Organism: Homo sapiens, class: Kinase, accessions: Q14289, gene: PTK2B, swissprot: FAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Blk (Organism: Homo sapiens, class: Kinase, accessions: P51451, gene: BLK, swissprot: BLK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Angiopoietin-1 receptor (Organism: Homo sapiens, class: Kinase, accessions: Q02763, gene: TEK, swissprot: TIE2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Organism: Homo sapiens, class: Kinase, accessions: Q14164, gene: IKBKE, swissprot: IKKE_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Peripheral plasma membrane protein CASK (Organism: Homo sapiens, class: Kinase, accessions: O14936, gene: CASK, swissprot: CSKP_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Dual serine/threonine and tyrosine protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q6XUX3, gene: DSTYK, swissprot: DUSTY_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Proto-oncogene tyrosine-protein kinase ROS (Organism: Homo sapiens, class: Kinase, accessions: P08922, gene: ROS1, swissprot: ROS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ephrin type-B receptor 6 (Organism: Homo sapiens, class: Kinase, accessions: O15197, gene: EPHB6, swissprot: EPHB6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase SIK2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H0K1, gene: SIK2, swissprot: SIK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase TAO3 (Organism: Homo sapiens, class: Kinase, accessions: Q9H2K8, gene: TAOK3, swissprot: TAOK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13233, gene: MAP3K1, swissprot: M3K1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Cyclin-dependent kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: P50613, gene: CDK7, swissprot: CDK7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Rho-associated protein kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: O75116, gene: ROCK2, swissprot: ROCK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Fyn (Organism: Homo sapiens, class: Kinase, accessions: P06241, gene: FYN, swissprot: FYN_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Macrophage colony-stimulating factor 1 receptor (Organism: Homo sapiens, class: Kinase, accessions: P07333, gene: CSF1R, swissprot: CSF1R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Uncharacterized serine/threonine-protein kinase SBK3 (Organism: Homo sapiens, class: Kinase, accessions: P0C264, gene: SBK3, swissprot: SBK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Macrophage-stimulating protein receptor (Organism: Mus musculus, class: Kinase, accessions: Q62190, gene: Mst1r, swissprot: RON_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Activin receptor type-1B (Organism: Homo sapiens, class: Kinase, accessions: P36896, gene: ACVR1B, swissprot: ACV1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase receptor Tie-1 (Organism: Homo sapiens, class: Kinase, accessions: P35590, gene: TIE1, swissprot: TIE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) TGF-beta receptor type-1 (Organism: Homo sapiens, class: Kinase, accessions: P36897, gene: TGFBR1, swissprot: TGFR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Proto-oncogene tyrosine-protein kinase receptor Ret (Organism: Homo sapiens, class: Kinase, accessions: P07949, gene: RET, swissprot: RET_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Myotonin-protein kinase (Organism: Homo sapiens, class: Kinase, accessions: Q09013, gene: DMPK, swissprot: DMPK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Epithelial discoidin domain-containing receptor 1 (Organism: Homo sapiens, class: Kinase, accessions: Q08345, gene: DDR1, swissprot: DDR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase receptor TYRO3 (Organism: Homo sapiens, class: Kinase, accessions: Q06418, gene: TYRO3, swissprot: TYRO3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Fes/Fps (Organism: Homo sapiens, class: Kinase, accessions: P07332, gene: FES, swissprot: FES_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Lck (Organism: Homo sapiens, class: Kinase, accessions: P06239, gene: LCK, swissprot: LCK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Leukocyte tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: P29376, gene: LTK, swissprot: LTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 19 (Organism: Homo sapiens, class: Kinase, accessions: Q56UN5, gene: MAP3K19, swissprot: M3K19_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase receptor UFO (Organism: Homo sapiens, class: Kinase, accessions: P30530, gene: AXL, swissprot: UFO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) BDNF/NT-3 growth factors receptor (Organism: Homo sapiens, class: Kinase, accessions: Q16620, gene: NTRK2, swissprot: NTRK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) NUAK family SNF1-like kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q9H093, gene: NUAK2, swissprot: NUAK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) SRSF protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q9UPE1, gene: SRPK3, swissprot: SRPK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase TXK (Organism: Homo sapiens, class: Kinase, accessions: P42681, gene: TXK, swissprot: TXK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) LIM domain kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: P53671, gene: LIMK2, swissprot: LIMK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) ALK tyrosine kinase receptor (Organism: Homo sapiens, class: Kinase, accessions: Q9UM73, gene: ALK, swissprot: ALK_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 12 (Organism: Homo sapiens, class: Kinase, accessions: Q12852, gene: MAP3K12, swissprot: M3K12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Receptor-interacting serine/threonine-protein kinase 1 (Organism: Homo sapiens, class: Kinase, accessions: Q13546, gene: RIPK1, swissprot: RIPK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Organism: Homo sapiens, class: Kinase, accessions: Q99755, gene: PIP5K1A, swissprot: PI51A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: Q99759, gene: MAP3K3, swissprot: M3K3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Cyclin-dependent kinase 11A (Organism: Homo sapiens, class: Kinase, accessions: Q9UQ88, gene: CDK11A, swissprot: CD11A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase RIO1 (Organism: Homo sapiens, class: Kinase, accessions: Q9BRS2, gene: RIOK1, swissprot: RIOK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Ribosomal protein S6 kinase beta-1 (Organism: Homo sapiens, class: Kinase, accessions: P23443, gene: RPS6KB1, swissprot: KS6B1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Serine/threonine-protein kinase ULK1 (Organism: Homo sapiens, class: Kinase, accessions: O75385, gene: ULK1, swissprot: ULK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Receptor-interacting serine/threonine-protein kinase 4 (Organism: Homo sapiens, class: Kinase, accessions: P57078, gene: RIPK4, swissprot: RIPK4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase kinase kinase kinase 2 (Organism: Homo sapiens, class: Kinase, accessions: Q12851, gene: MAP4K2, swissprot: M4K2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Tyrosine-protein kinase Mer (Organism: Homo sapiens, class: Kinase, accessions: Q12866, gene: MERTK, swissprot: MERTK_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Mitogen-activated protein kinase 7 (Organism: Homo sapiens, class: Kinase, accessions: Q13164, gene: MAPK7, swissprot: MK07_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Non-receptor tyrosine-protein kinase TNK1 (Organism: Homo sapiens, class: Kinase, accessions: Q13470, gene: TNK1, swissprot: TNK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL601719) Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur d'Origine Nantais (RON). Translocations can affect the ALK gene resulting in the expression of oncogenic fusion proteins. The formation of ALK fusion proteins results in activation and dysregulation of the gene's expression and signaling which can contribute to increased cell proliferation and survival in tumors expressing these proteins. Crizotinib demonstrated concentration-dependent inhibition of ALK, ROS1, and c-Met phosphorylation in cell-based assays using tumor cell lines and demonstrated antitumor activity in mice bearing tumor xenografts that expressed echinoderm microtubule-associated protein-like 4 (EML4)- or nucleophosmin (NPM)-ALK fusion proteins or c-Met. antineoplastic agent (Code: CHEBI:35610) biomarker (Code: CHEBI:59163) Kinase Inhibitor (Code: N0000175605) Cytochrome P450 3A Inhibitors (Code: N0000190114) Receptor Tyrosine Kinase Inhibitors (Code: N0000020000) Cytochrome P450 2B6 Inhibitors (Code: N0000182139) P-Glycoprotein Inhibitors (Code: N0000185503) Organic Cation Transporter 1 Inhibitors (Code: N0000191265) Organic Cation Transporter 2 Inhibitors (Code: N0000187061) Enzyme Inhibitors (Code: D004791) Protein Kinase Inhibitors (Code: D047428) 2011-08-26 FDA 2WGJ
2XP2
2YFX
3ZBF
4ANQ
4ANS
4C9W
5AAA
5AAB
5AAC
4C9X
Click to view deferiprone iron (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021825s003lbl.pdf) a chelating agent with an affinity for ferric ion (iron III) indicated for the treatment of patients with transfusional iron overload due to thalassemia syndromes protective agent (Code: CHEBI:50267) Iron Chelating Activity (Code: N0000000144) Iron Chelator (Code: N0000175522) Chelating Agents (Code: D002614) Iron Chelating Agents (Code: D007502) Sequestering Agents (Code: D064449) 2011-10-14 FDA
Click to view hydroxyprogesterone caproate Progesterone receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P06401, gene: PGR, swissprot: PRGR_HUMAN) agonist (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021945s005lbl.pdf) Glucocorticoid receptor (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P04150, gene: NR3C1, swissprot: GCR_HUMAN) None (Source: DRUG MATRIX) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: DRUG MATRIX) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: DRUG MATRIX) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) None (Source: DRUG MATRIX) Androgen receptor (Organism: Rattus norvegicus, class: Transcription factor, accessions: P15207, gene: Ar, swissprot: ANDR_RAT) None (Source: DRUG MATRIX) Progesterone receptor (Organism: Bos taurus, class: Transcription factor, accessions: Q690N0, gene: PGR, swissprot: Q690N0_BOVIN) None (Source: DRUG MATRIX) Sex hormone-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P04278, gene: SHBG, swissprot: SHBG_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1062) Corticosteroid-binding globulin (Organism: Homo sapiens, class: Secreted, accessions: P08185, gene: SERPINA6, swissprot: CBG_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1062) None Progesterone Congeners (Code: N0000011301) Progestin (Code: N0000175602) Estrogen Antagonists (Code: D004965) Hormone Antagonists (Code: D006727) Hormones (Code: D006728) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Progestins (Code: D011372) 1974-12-26 FDA
Click to view talbutal GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200802) None 1960 FDA
Click to view ethanol GABA A receptor alpha-4/beta-2/delta (Organism: Homo sapiens, class: Ion channel, accessions: O14764|P47870|P48169, gene: GABRA4|GABRB2|GABRD, swissprot: GBRA4_HUMAN|GBRB2_HUMAN|GBRD_HUMAN) None (Source: WOMBAT-PK) Glycine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: P23416, gene: GLRA2, swissprot: GLRA2_HUMAN) None (Source: WOMBAT-PK) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) None (Source: WOMBAT-PK) A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. antiseptic drug (Code: CHEBI:48218) polar solvent (Code: CHEBI:48354) central nervous system depressant (Code: CHEBI:35488) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Solvents (Code: D012997) 1946-01-17 FDA
Click to view guanidine Voltage-gated potassium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43525|O43526|O95259|P16389|P17658|P22001|P22459|P22460|P48547|P51787|P56696|Q03721|Q09470|Q12809|Q14003|Q14721|Q16322|Q6PIU1|Q8NCM2|Q8TAE7|Q8TDN1|Q8TDN2|Q92953|Q96KK3|Q96L42|Q96PR1|Q96RP8|Q9BQ31|Q9H252|Q9H3M0|Q9NR82|Q9NS40|Q9NSA2|Q9NZV8|Q9UIX4|Q9UJ96|Q9UK17|Q9ULD8|Q9ULS6|Q9UQ05, gene: KCNA1|KCNA10|KCNA2|KCNA3|KCNA4|KCNA5|KCNA6|KCNA7|KCNB1|KCNB2|KCNC1|KCNC2|KCNC3|KCNC4|KCND1|KCND2|KCND3|KCNF1|KCNG1|KCNG2|KCNG3|KCNG4|KCNH1|KCNH2|KCNH3|KCNH4|KCNH5|KCNH6|KCNH7|KCNH8|KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5|KCNS1|KCNS2|KCNS3|KCNV1|KCNV2, swissprot: KCA10_HUMAN|KCNA1_HUMAN|KCNA2_HUMAN|KCNA3_HUMAN|KCNA4_HUMAN|KCNA5_HUMAN|KCNA6_HUMAN|KCNA7_HUMAN|KCNB1_HUMAN|KCNB2_HUMAN|KCNC1_HUMAN|KCNC2_HUMAN|KCNC3_HUMAN|KCNC4_HUMAN|KCND1_HUMAN|KCND2_HUMAN|KCND3_HUMAN|KCNF1_HUMAN|KCNG1_HUMAN|KCNG2_HUMAN|KCNG3_HUMAN|KCNG4_HUMAN|KCNH1_HUMAN|KCNH2_HUMAN|KCNH3_HUMAN|KCNH4_HUMAN|KCNH5_HUMAN|KCNH6_HUMAN|KCNH7_HUMAN|KCNH8_HUMAN|KCNQ1_HUMAN|KCNQ2_HUMAN|KCNQ3_HUMAN|KCNQ4_HUMAN|KCNQ5_HUMAN|KCNS1_HUMAN|KCNS2_HUMAN|KCNS3_HUMAN|KCNV1_HUMAN|KCNV2_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL821) A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. Acetylcholine Releasing Agent (Code: N0000175772) Increased Acetylcholine Activity (Code: N0000009079) 1939-10-02 FDA
Click to view corticorelin ovine used in diagnosis of adrenocortical insufficiency & Cushing's syndrome; AA sequence given in first source; MF C205-H339-N59-O63-S; RN given refers to triflutate salt; RN for parent cpd not avail 3/94 diagnostic agent (Code: CHEBI:33295) 1996-05-23 FDA
Click to view vinyl ether a clear, nearly colorless, volatile liquid which was used as an inhalation anesthetic Anesthetics (Code: D000777) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492)
Click to view propiolactone Disinfectant used in vapor form to sterilize vaccines, grafts, etc. The vapor is very irritating and the liquid form is carcinogenic. Anti-Infective Agents (Code: D000890) Disinfectants (Code: D004202) 1981 FDA
Click to view ethyl chloride A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine. Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) None FDA
Click to view glycine Sodium- and chloride-dependent glycine transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P48067, gene: SLC6A9, swissprot: SC6A9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL773) Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL773) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL773) A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. nutraceutical (Code: CHEBI:50733) hepatoprotective agent (Code: CHEBI:62868) NMDA receptor agonist (Code: CHEBI:64571) Glycine Agents (Code: D018684) Neurotransmitter Agents (Code: D018377) 1976-05-25 FDA
Click to view acetohydroxamic acid Urease (Organism: Canavalia ensiformis, class: Enzyme, accessions: P07374, gene: None, swissprot: UREA_CANEN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL734) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL734) Bacterial urease (Organism: Escherichia coli, class: Enzyme, accessions: Q03282|Q03283|Q03284, gene: ureA|ureB|ureC, swissprot: URE1_ECOLX|URE2_ECOLX|URE3_ECOLX) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL734) urease inhibitor Urease Inhibitor (Code: N0000175611) Urease Inhibitors (Code: N0000175087) Enzyme Inhibitors (Code: D004791) 1983-05-31 FDA 5N5J
5N5K
4H9M
4A7B
3KEC
3LIK
3LIL
3LJG
3LKA
3DPF
3BA0
2OZR
2OW9
2HU6
1Y93
1UTT
1UTZ
1OS2
1E9Y
4UBP
1AM6
1FWE
Click to view hydroxycarbamide Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL467) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL467) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL467) Ribonucleoside-diphosphate reductase subunit M2 (Organism: Homo sapiens, class: Enzyme, accessions: P31350, gene: RRM2, swissprot: RIR2_HUMAN) inhibitor (Source: WOMBAT-PK) Ribonucleoside-diphosphate reductase large subunit (Organism: Homo sapiens, class: Enzyme, accessions: P23921, gene: RRM1, swissprot: RIR1_HUMAN) inhibitor (Source: WOMBAT-PK) An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. antineoplastic agent (Code: CHEBI:35610) immunomodulator (Code: CHEBI:50846) Antimetabolite (Code: N0000180853) Urea (Code: N0000006999) Antineoplastic Agents (Code: D000970) Antisickling Agents (Code: D000986) Enzyme Inhibitors (Code: D004791) Hematologic Agents (Code: D006401) Nucleic Acid Synthesis Inhibitors (Code: D019384) 1967-12-07 FDA 3UB9
2GEH
Click to view propylene glycol A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. protic solvent (Code: CHEBI:48356) Pharmaceutic Aids (Code: D010592) Pharmaceutical Vehicles (Code: D014677) Solvents (Code: D012997) None FDA
Click to view mercaptamine cystine (Organism: None, class: Unnatural amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002465/WC500151313.pdf) A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS. Cystine Depleting Agents (Code: D065104) Cystine Depleting Agent (Code: N0000187051) Cystine Disulfide Reduction (Code: N0000175549) 1994-08-15 FDA
Click to view dimethyl sulfoxide A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. polar aprotic solvent (Code: CHEBI:48358) non-narcotic analgesic (Code: CHEBI:35481) antidote (Code: CHEBI:50247) Antioxidants (Code: D000975) Cryoprotective Agents (Code: D003451) Free Radical Scavengers (Code: D016166) Protective Agents (Code: D020011) Solvents (Code: D012997) 1978-04-04 FDA
Click to view fomepizole Alcohol dehydrogenase (Organism: Equus caballus, class: Enzyme, accessions: P00327|P00328, gene: None, swissprot: ADH1E_HORSE|ADH1S_HORSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1308) Alcohol dehydrogenase (Organism: Homo sapiens, class: Enzyme, accessions: P00325|P00326|P07327, gene: ADH1A|ADH1B|ADH1C, swissprot: ADH1A_HUMAN|ADH1B_HUMAN|ADH1G_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1308) alcohol dehyrogenase inhibitor antidote (Code: CHEBI:50247) protective agent (Code: CHEBI:50267) Antidotes (Code: D000931) Protective Agents (Code: D020011) 1997-12-04 FDA
Click to view piperazine Gamma-aminobutyric acid receptor subunit beta (Organism: Caenorhabditis elegans, class: Ion channel, accessions: O18276, gene: gab-1, swissprot: GBRB_CAEEL) None (Source: WOMBAT-PK) has anthelmintic action Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Antinematodal Agents (Code: D000969) Antiparasitic Agents (Code: D000977) 1954-07-12 FDA
Click to view cyverine None
Click to view deanol Creatine transporter (Organism: Rattus norvegicus, class: Unclassified, accessions: P28570, gene: Slc6a8, swissprot: SC6A8_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1135) High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1135) An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood. curing agent (Code: CHEBI:75358) Anti-Dyskinesia Agents (Code: D018726) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Psychotropic Drugs (Code: D011619) 1963 YEAR INTRODUCED
Click to view benzyl alcohol A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring, benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate solvent (Code: CHEBI:46787) fragrance (Code: CHEBI:48318) Pediculicide (Code: N0000181811) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2009-04-09 FDA 2AMQ
2HOB
2Q6F
3D23
3IWM
4II8
5EB5
5EU8
5GWY
5GWZ
Click to view lactic acid A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) 2006-10-25 FDA 5WBF
5XR2
5I8T
4QO8
4N3G
4N3N
4M49
4JNK
2Y4J
2WNZ
3KB6
2ZZV
2ZZW
2ZZX
2P1E
2NLI
2IMP
2FN7
2FLT
1W3Q
1C0K
1QH9
1C0Q
1C0R

Click to view glycerol A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent. solvent (Code: CHEBI:46787) detergent (Code: CHEBI:27780) Non-Standardized Chemical Allergen (Code: N0000185370) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Increased IgG Production (Code: N0000185001) Allergens (Code: N0000171131) Glycerol (Code: N0000006566) Cryoprotective Agents (Code: D003451) Protective Agents (Code: D020011) Solvents (Code: D012997) 1982-05-06 FDA 3H3N
Click to view methylpentynol a tertiary hexanol with hypnotic/sedative and anticonvulsant effects, was used for the treatment of insomnia
Click to view secretin porcine stimulate pancreatic ductal cells to secrete pancreas fluid in large volumes that contain bicarbonate 2002-04-04 FDA
Click to view loxoprofen Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19299) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19299) None Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) prodrug (Code: CHEBI:50266) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 2005-12-22 PMDA
Click to view aminopicoline None 2EUT
3E67
Click to view glutaral One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative. cross-linking reagent (Code: CHEBI:50684) Anti-Infective Agents (Code: D000890) Cross-Linking Reagents (Code: D003432) Disinfectants (Code: D004202) Fixatives (Code: D005404) Indicators and Reagents (Code: D007202)
Click to view cycloserine Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL771) Glutamate receptor ionotropic, NMDA 2C (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00961, gene: Grin2c, swissprot: NMDE3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL771) Alanine racemase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WQA8, gene: alr, swissprot: ALR_MYCTO) None (Source: WOMBAT-PK) Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL771) D-alanine--D-alanine ligase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WP31, gene: ddl, swissprot: DDL_MYCTU) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL771) Alanine racemase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WQA9, gene: alr, swissprot: ALR_MYCTU) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL771) Glutamate receptor ionotropic, NMDA 2D (Organism: Homo sapiens, class: Ion channel, accessions: O15399, gene: GRIN2D, swissprot: NMDE4_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 3B (Organism: Homo sapiens, class: Ion channel, accessions: O60391, gene: GRIN3B, swissprot: NMD3B_HUMAN) None (Source: WOMBAT-PK) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q05586, gene: GRIN1, swissprot: NMDZ1_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 2A (Organism: Homo sapiens, class: Ion channel, accessions: Q12879, gene: GRIN2A, swissprot: NMDE1_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 2B (Organism: Homo sapiens, class: Ion channel, accessions: Q13224, gene: GRIN2B, swissprot: NMDE2_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 2C (Organism: Homo sapiens, class: Ion channel, accessions: Q14957, gene: GRIN2C, swissprot: NMDE3_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) None (Source: WOMBAT-PK) Antibiotic substance produced by Streptomyces garyphalus. NMDA receptor agonist (Code: CHEBI:64571) antiinfective agent (Code: CHEBI:35441) antitubercular agent (Code: CHEBI:33231) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Antibiotics, Antitubercular (Code: D000904) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Noxae (Code: D009676) Renal Agents (Code: D012076) 1964-06-29 FDA 1PB9
1XQL
Click to view aminobutyric acid Gamma-aminobutyric acid receptor subunit rho-1 (Organism: Homo sapiens, class: Ion channel, accessions: P24046, gene: GABRR1, swissprot: GBRR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P30531, gene: SLC6A1, swissprot: SC6A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 3 (Organism: Homo sapiens, class: Transporter, accessions: P48066, gene: SLC6A11, swissprot: S6A11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent betaine transporter (Organism: Homo sapiens, class: Transporter, accessions: P48065, gene: SLC6A12, swissprot: S6A12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Gamma-aminobutyric acid receptor subunit gamma-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23574, gene: Gabrg1, swissprot: GBRG1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Gamma-aminobutyric acid receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P23576, gene: Gabra2, swissprot: GBRA2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 1 (Organism: Rattus norvegicus, class: Transporter, accessions: P23978, gene: Slc6a1, swissprot: SC6A1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31646, gene: Slc6a13, swissprot: S6A13_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 1 (Organism: Mus musculus, class: Transporter, accessions: P31648, gene: Slc6a1, swissprot: SC6A1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 2 (Organism: Mus musculus, class: Unclassified, accessions: P31649, gene: Slc6a13, swissprot: S6A13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Sodium- and chloride-dependent GABA transporter 3 (Organism: Mus musculus, class: Unclassified, accessions: P31650, gene: Slc6a11, swissprot: S6A11_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) Gamma-aminobutyric acid receptor subunit alpha-1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P62813, gene: Gabra1, swissprot: GBRA1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL96) The most common inhibitory neurotransmitter in the central nervous system. GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) None FDA
Click to view choline Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Creatine transporter (Organism: Rattus norvegicus, class: Unclassified, accessions: P28570, gene: Slc6a8, swissprot: SC6A8_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) High affinity choline transporter 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BGY9, gene: Slc5a7, swissprot: SC5A7_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL920) A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. Antimetabolites (Code: D000963) Central Nervous System Agents (Code: D002491) Gastrointestinal Agents (Code: D005765) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Lipotropic Agents (Code: D008082) Nootropic Agents (Code: D018697) None FDA
Click to view nicotinyl alcohol Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE. Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) 1964 CDSCO (INDIA) 1R16
Click to view resorcinol Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24147) an antiseptic and disinfectant used for temporary relief of itching None FDA 1EVR
1QIZ
2OLY
2OLZ
2OM0
2OM1
2OMH
2OMI
2W44
3AQT
3ZU1
4AJX
4DM3
4E49
4QOO
4Z10
Click to view hydroquinone Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase (Organism: Dicentrarchus labrax, class: Unclassified, accessions: Q2PCB5, gene: ca, swissprot: Q2PCB5_DICLA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL537) skin depigmentation agent skin lightening agent (Code: CHEBI:85046) Antioxidants (Code: D000975) Mutagens (Code: D009153) Noxae (Code: D009676) Protective Agents (Code: D020011) Radiation-Protective Agents (Code: D011837) Depigmenting Activity (Code: N0000175851) Melanin Synthesis Inhibitor (Code: N0000175854) Melanin Synthesis Inhibitors (Code: N0000175850) 2002-01-18 FDA 3ZOD
3ZOF
4E3H
4QOP
5FSE
5I3A
5I3B
Click to view histamine Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H2 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P47747, gene: HRH2, swissprot: HRH2_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H4 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9H3N8, gene: HRH4, swissprot: HRH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H1 receptor (Organism: Homo sapiens, class: GPCR, accessions: P35367, gene: HRH1, swissprot: HRH1_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H4 receptor (Organism: Mus musculus, class: GPCR, accessions: Q91ZY2, gene: Hrh4, swissprot: HRH4_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H3 receptor (Organism: Mus musculus, class: GPCR, accessions: P58406, gene: Hrh3, swissprot: HRH3_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H4 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q91ZY1, gene: Hrh4, swissprot: HRH4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: PDSP) Histamine H1 receptor (Organism: Cavia porcellus, class: GPCR, accessions: P31389, gene: HRH1, swissprot: HRH1_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H1 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P31390, gene: Hrh1, swissprot: HRH1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H4 receptor (Organism: Cavia porcellus, class: Unclassified, accessions: Q91ZY3, gene: HRH4, swissprot: Q91ZY3_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H3 receptor (Organism: Cavia porcellus, class: Unclassified, accessions: Q9JI35, gene: HRH3, swissprot: HRH3_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL90) An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) 1939-04-25 FDA 1AVN
1IKE
1JQD
1KAR
1NP1
1QFT
1QFV
1U18
2QEB
2X45
3BU1
3G7X
3RXH
4XMF
Click to view betazole Histamine H2 receptor (Organism: Homo sapiens, class: GPCR, accessions: P25021, gene: HRH2, swissprot: HRH2_HUMAN) agonist (Source: WOMBAT-PK) A histamine H2 agonist used clinically to test gastric secretory function. histamine agonist (Code: CHEBI:35678) diagnostic agent (Code: CHEBI:33295) gastrointestinal drug (Code: CHEBI:55324) Gastrointestinal Agents (Code: D005765) Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) 1982-01-01 FDA
Click to view thiamazole Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: WOMBAT-PK) Dopamine beta-hydroxylase (Organism: Bos taurus, class: Unclassified, accessions: P15101, gene: DBH, swissprot: DOPO_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1515) Lactoperoxidase (Organism: Bos taurus, class: Enzyme, accessions: P80025, gene: LPO, swissprot: PERL_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1515) Lactoperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P22079, gene: LPO, swissprot: PERL_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1515) A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. antithyroid drug (Code: CHEBI:50671) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Thyroid Hormone Synthesis Inhibitor (Code: N0000175918) Thyroid Hormone Synthesis Inhibitors (Code: N0000175917) 1950-06-21 FDA 2GVC
4IG5
5FF1
5GSN
Click to view tuaminoheptane an adrenergic agent used as a nasal decongestant in the form of the base (for inhalation) or the sulfate salt (topical solution) 1990-05-25 Swissmedic (Switzerland)
Click to view methylhexaneamine sympathomimetic aliphatic amine with vasoconstrictor activity
Click to view cacodylic acid An arsenical that has been used as a dermatologic agent and as an herbicide. Herbicides (Code: D006540) Pesticides (Code: D010575)
Click to view fumaric acid Egl nine homolog 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9GZT9, gene: EGLN1, swissprot: EGLN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL503160) see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters food acidity regulator (Code: CHEBI:64049)
Click to view succinic acid Egl nine homolog 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q9GZT9, gene: EGLN1, swissprot: EGLN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL576) Succinate receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q9BXA5, gene: SUCNR1, swissprot: SUCR1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3637) A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) anti-ulcer drug (Code: CHEBI:49201) nutraceutical (Code: CHEBI:50733)
Click to view betaine homocysteine (Organism: None, class: Unnatural amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020576s010lbl.pdf) A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341) Antimetabolites (Code: D000963) Gastrointestinal Agents (Code: D005765) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Lipotropic Agents (Code: D008082) Methylating Activity (Code: N0000175804) Methylating Agent (Code: N0000175805) 1996-10-25 FDA 4H5W
3T2J
5HIJ
Click to view aminohydroxybutyric acid None
Click to view oxymethurea None
Click to view noxytiolin Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns. Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891)
Click to view trometamol An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424) Buffers (Code: D002021) Excipients (Code: D005079) Pharmaceutic Aids (Code: D010592) Pharmaceutical Vehicles (Code: D014677) 1965-12-16 FDA 5WZM
Click to view cysteine Cystine/glutamate transporter (Organism: Homo sapiens, class: Transporter, accessions: Q9UPY5, gene: SLC7A11, swissprot: XCT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL863) A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. 1986-10-22 FDA 4Z82
4XF1
Click to view nicotinamide NAD-dependent deacetylase sirtuin 3 (Organism: Homo sapiens, class: Enzyme, accessions: Q9NTG7, gene: SIRT3, swissprot: SIR3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) NAD-dependent protein deacetylase sirtuin-2 (Organism: Homo sapiens, class: Enzyme, accessions: Q8IXJ6, gene: SIRT2, swissprot: SIR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) NAD-dependent protein deacylase sirtuin-5, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9NXA8, gene: SIRT5, swissprot: SIR5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) NAD-dependent deacetylase HST2 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53686, gene: HST2, swissprot: HST2_YEAST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) Putative silent information regulator 2 (Organism: Leishmania infantum, class: Unclassified, accessions: Q8I6E4, gene: SIR2RP1, swissprot: Q8I6E4_LEIIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) NAD-dependent protein deacetylase sirtuin-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q96EB6, gene: SIRT1, swissprot: SIR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1140) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) None (Source: WOMBAT-PK) Hydroxycarboxylic acid receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P49019, gene: HCAR3, swissprot: HCAR3_HUMAN) None (Source: WOMBAT-PK) Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Organism: Homo sapiens, class: Enzyme, accessions: Q15274, gene: QPRT, swissprot: NADC_HUMAN) None (Source: WOMBAT-PK) Nicotinamide N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P40261, gene: NNMT, swissprot: NNMT_HUMAN) None (Source: WOMBAT-PK) An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. neuroprotective agent (Code: CHEBI:63726) anti-inflammatory agent (Code: CHEBI:67079) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) 1953-02-20 FDA 5V4V
1DMA
1ISI
1ISM
1R15
1YC2
1YC5
2A15
2C8A
2E5D
2H4J
2HJH
2OD9
2OTV
2QHF
2QQG
2R6V
2R9J
2Z77
2ZB7
3DZG
3I9J
3NN0
3O94
3ROD
3ROP
3ROZ
3U9H
3UPW
3ZJQ
4A3U
4AE1
4HYF
4RMJ
4YP2
5CF9
5J6H
5M10
5N3H
5VW4
5VW5
5VW9
5WQP
Click to view nicotinic acid Hydroxycarboxylic acid receptor 2 (Organism: Mus musculus, class: GPCR, accessions: Q9EP66, gene: Hcar2, swissprot: HCAR2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL573) Hydroxycarboxylic acid receptor 2 (Organism: Rattus norvegicus, class: GPCR, accessions: Q80Z39, gene: Hcar2, swissprot: HCAR2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL573) Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL573) Nicotinamide phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P43490, gene: NAMPT, swissprot: NAMPT_HUMAN) None (Source: WOMBAT-PK) Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Organism: Homo sapiens, class: Enzyme, accessions: Q15274, gene: QPRT, swissprot: NADC_HUMAN) None (Source: WOMBAT-PK) Nicotinamide N-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P40261, gene: NNMT, swissprot: NNMT_HUMAN) None (Source: WOMBAT-PK) Hydroxycarboxylic acid receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: P49019, gene: HCAR3, swissprot: HCAR3_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1588) A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. B vitamin (Code: CHEBI:75769) vasodilator agent (Code: CHEBI:35620) antidote (Code: CHEBI:50247) antilipemic drug (Code: CHEBI:35679) Nicotinic Acid (Code: N0000175594) Nicotinic Acids (Code: N0000007641) Antimetabolites (Code: D000963) Cardiovascular Agents (Code: D002317) Growth Substances (Code: D006133) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vasodilator Agents (Code: D014665) Vitamin B Complex (Code: D014803) 1957-07-24 FDA 1D0V
1FSL
1ICR
1ICU
1ICV
1JHA
1JHO
1JHQ
1JHR
1JHV
1JHY
1L4N
1L5K
1L5L
1L5M
1LH6
2F7F
2LH6
2WT9
2XRH
3CI8
3HRD
3I45
3O14
3R2J
3WAR
4BN9
4KQI
Click to view mecysteine None Expectorants (Code: D005100) Respiratory System Agents (Code: D019141)
Click to view pyrazinamide Cyclopropane mycolic acid synthase 1 (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WPB6, gene: cmaA1, swissprot: CMAS1_MYCTO) None (Source: WOMBAT-PK) Amidase; Nicotinamidase; Nicotinamidase/pyrazinamidase; Pyrazinamidase; Pyrazinamidase/nicotinamidase; Pyrazinamidase/nicotinamidase PncA (Organism: Mycobacterium tuberculosis, class: Enzyme, accessions: Q50575, gene: pncA, swissprot: Q50575_MYCTX) None (Source: WOMBAT-PK) 3-oxoacyl-ACP synthase; Fatty acid synthase Fas; Probable fatty acid synthase Fas (Fatty acid synthetase) (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P95029, gene: fas, swissprot: P95029_MYCTU) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL614) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: WOMBAT-PK) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: WOMBAT-PK) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) None (Source: WOMBAT-PK) A pyrazine that is used therapeutically as an antitubercular agent. antitubercular agent (Code: CHEBI:33231) prodrug (Code: CHEBI:50266) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) 1971-06-03 FDA 3R4X
3R55
5FPD
Click to view guaiacol Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL13766) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL13766) An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747) expectorant (Code: CHEBI:77035) 3HT9
4A6Z
4A78
4G05
4QOQ
Click to view dimercaprol An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning. Metal Chelating Activity (Code: N0000175472) Metal Chelator (Code: N0000175473) Chelating Agents (Code: D002614) Sequestering Agents (Code: D064449) 1946-05-06 FDA
Click to view foscarnet DNA polymerase catalytic subunit (Organism: Human herpesvirus 1 (strain 17), class: Enzyme, accessions: P04293, gene: None, swissprot: DPOL_HHV11) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL666) Reverse transcriptase/RNaseH (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q72547, gene: pol, swissprot: Q72547_9HIV1) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL666) DNA polymerase catalytic subunit (Organism: Human cytomegalovirus (strain AD169), class: Enzyme, accessions: P08546, gene: UL54, swissprot: DPOL_HCMVA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL666) Reverse transcriptase (Organism: Human immunodeficiency virus 1, class: Enzyme, accessions: Q9WKE8, gene: reverse transcriptas, swissprot: Q9WKE8_9HIV1) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL666) An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. antiviral drug (Code: CHEBI:36044) DNA Polymerase Inhibitors (Code: N0000020060) Pyrophosphate Analog (Code: N0000175469) Pyrophosphate Analog DNA Polymerase Inhibitor (Code: N0000175470) Chelating Activity (Code: N0000000087) Anti-Infective Agents (Code: D000890) Anti-Retroviral Agents (Code: D044966) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) Reverse Transcriptase Inhibitors (Code: D018894) 1991-09-27 FDA 5HP1
2IT4
X ray
Click to view fluroxene None
Click to view phloroglucinol Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL473159) A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent. Indicators and Reagents (Code: D007202) 4HDK
5MG5
Click to view orazamide None 1971 YEAR INTRODUCED 3CL8
Click to view chloral hydrate A hypnotic and sedative used in the treatment of INSOMNIA. sedative (Code: CHEBI:35717) general anaesthetic (Code: CHEBI:38869) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) 1840-01-01 YEAR INTRODUCED
Click to view pyrithione Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1356238) split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935)
Click to view thiouracil Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis. Antithyroid Agents (Code: D013956) Cardiovascular Agents (Code: D002317) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Vasodilator Agents (Code: D014665) 4WS8
Click to view dichloroacetic acid [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15118, gene: PDK1, swissprot: PDK1_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15119, gene: PDK2, swissprot: PDK2_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q15120, gene: PDK3, swissprot: PDK3_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (Organism: Homo sapiens, class: Kinase, accessions: Q16654, gene: PDK4, swissprot: PDK4_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/9405293) A derivative of ACETIC ACID that contains two CHLORINE atoms attached to its methyl group.
Click to view flucytosine Thymidylate synthase (Organism: Cryptococcus neoformans var. neoformans serotype D (strain B-3501A), class: Enzyme, accessions: P0CS13, gene: TMP1, swissprot: TYSY_CRYNB) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1463) Thymidylate synthase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: P12461, gene: TMP1, swissprot: TYSY_CANAL) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1463) ATP-dependent molecular chaperone HSP82 (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Cytosolic other, accessions: P02829, gene: HSP82, swissprot: HSP82_YEAST) None (Source: WOMBAT-PK) 5-hydroxytryptamine receptor 2A (Organism: Homo sapiens, class: GPCR, accessions: P28223, gene: HTR2A, swissprot: 5HT2A_HUMAN) None (Source: WOMBAT-PK) A fluorinated cytosine analog that is used as an antifungal agent. Inside the fungal cell, flucytosine is rapidly converted to fluorouracil by the enzyme cytosine deaminase. Fluorouracil exerts its antifungal activity through the subsequent conversion into several active metabolites, which inhibit protein synthesis by being falsely incorporated into fungal RNA or interfere with the biosynthesis of fungal DNA through the inhibition of the enzyme thymidylate synthetase prodrug (Code: CHEBI:50266) Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antifungal (Code: N0000175467) Anti-Infective Agents (Code: D000890) Antifungal Agents (Code: D000935) Antimetabolites (Code: D000963) Noxae (Code: D009676) 1971-11-26 FDA 4R88
Click to view vigabatrin Gamma-amino-N-butyrate transaminase (Organism: Rattus norvegicus, class: Unclassified, accessions: P50554, gene: Abat, swissprot: GABT_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL89598) 4-aminobutyrate aminotransferase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P80404, gene: ABAT, swissprot: GABT_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL89598) The precise mechanism of vigabatrin's anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system. anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) 2009-08-21 FDA
Click to view metformin Dipeptidyl peptidase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27487, gene: DPP4, swissprot: DPP4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1431) Mitochondrial complex I (NADH dehydrogenase) (Organism: Homo sapiens, class: Enzyme, accessions: O00217|O00483|O14561|O15239|O43181|O43674|O43676|O43677|O43678|O43920|O75251|O75306|O75380|O75438|O75489|O95139|O95167|O95168|O95169|O95178|O95182|O95298|O95299|O96000|P03886|P03891|P03897|P03901|P03905|P03915|P03923|P17568|P19404|P28331|P49821|P51970|P56181|P56556|Q16718|Q16795|Q86Y39|Q8N183|Q9BU61|Q9NRX3|Q9NX14|Q9P032|Q9P0J0|Q9UI09|Q9Y375|Q9Y6M9, gene: MT-ND1|MT-ND2|MT-ND3|MT-ND4|MT-ND4L|MT-ND5|MT-ND6|NDUFA1|NDUFA10|NDUFA11|NDUFA12|NDUFA13|NDUFA2|NDUFA3|NDUFA4|NDUFA4L2|NDUFA5|NDUFA6|NDUFA7|NDUFA8|NDUFA9|NDUFAB1|NDUFAF1|NDUFAF2|NDUFAF3|NDUFAF4|NDUFB1|NDUFB10|NDUFB11|NDUFB2|NDUFB3|NDUFB4|NDUFB5|NDUFB6|NDUFB7|NDUFB8|NDUFB9|NDUFC1|NDUFC2|NDUFS1|NDUFS2|NDUFS3|NDUFS4|NDUFS5|NDUFS6|NDUFS7|NDUFS8|NDUFV1|NDUFV2|NDUFV3, swissprot: ACPM_HUMAN|CIA30_HUMAN|MIMIT_HUMAN|NDUA1_HUMAN|NDUA2_HUMAN|NDUA3_HUMAN|NDUA4_HUMAN|NDUA5_HUMAN|NDUA6_HUMAN|NDUA7_HUMAN|NDUA8_HUMAN|NDUA9_HUMAN|NDUAA_HUMAN|NDUAB_HUMAN|NDUAC_HUMAN|NDUAD_HUMAN|NDUB1_HUMAN|NDUB2_HUMAN|NDUB3_HUMAN|NDUB4_HUMAN|NDUB5_HUMAN|NDUB6_HUMAN|NDUB7_HUMAN|NDUB8_HUMAN|NDUB9_HUMAN|NDUBA_HUMAN|NDUBB_HUMAN|NDUC1_HUMAN|NDUC2_HUMAN|NDUF3_HUMAN|NDUF4_HUMAN|NDUS1_HUMAN|NDUS2_HUMAN|NDUS3_HUMAN|NDUS4_HUMAN|NDUS5_HUMAN|NDUS6_HUMAN|NDUS7_HUMAN|NDUS8_HUMAN|NDUV1_HUMAN|NDUV2_HUMAN|NDUV3_HUMAN|NU1M_HUMAN|NU2M_HUMAN|NU3M_HUMAN|NU4LM_HUMAN|NU4M_HUMAN|NU5M_HUMAN|NU6M_HUMAN|NUA4L_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1431) 5'-AMP-activated protein kinase subunit beta-1 (Organism: Homo sapiens, class: Kinase, accessions: Q9Y478, gene: PRKAB1, swissprot: AAKB1_HUMAN) None (Source: WOMBAT-PK) Solute carrier family 22 member 3 (Organism: Homo sapiens, class: Transporter, accessions: O75751, gene: SLC22A3, swissprot: S22A3_HUMAN) None (Source: WOMBAT-PK) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) None (Source: WOMBAT-PK) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) None (Source: WOMBAT-PK) an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization hypoglycemic agent (Code: CHEBI:35526) Biguanide (Code: N0000175565) Biguanides (Code: N0000007698) Hypoglycemic Agents (Code: D007004) 1995-03-03 FDA 5G5J
Click to view octodrine None
Click to view oxiniacic acid None
Click to view fluorouracil Thymidylate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P04818, gene: TYMS, swissprot: TYSY_HUMAN) inhibitor (Source: WOMBAT-PK) Thymidylate synthase (Organism: Mus musculus, class: Enzyme, accessions: P07607, gene: Tyms, swissprot: TYSY_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL185) Uracil phosphoribosyltransferase (Organism: Escherichia coli (strain K12), class: Unclassified, accessions: P0A8F0, gene: upp, swissprot: UPP_ECOLI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL185) ATP-binding cassette sub-family C member 11 (Organism: Homo sapiens, class: Transporter, accessions: Q96J66, gene: ABCC11, swissprot: ABCCB_HUMAN) None (Source: WOMBAT-PK) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) None (Source: WOMBAT-PK) a nucleoside metabolic inhibitor that interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA); these affect rapidly growing cells and may lead to cell death. radiosensitizing agent (Code: CHEBI:132992) antineoplastic agent (Code: CHEBI:35610) immunosuppressive agent (Code: CHEBI:35705) Nucleic Acid Synthesis Inhibitors (Code: N0000000233) Nucleoside Metabolic Inhibitor (Code: N0000175595) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) 1962-04-25 FDA 1H7X
1RXC
1UPF
3KVR
3KVV
3NAI
3NBQ
4E1V
4O0O
4TXN
4WRY
4WRZ
4WS0
4WS1
5IAO
5SXC
Click to view aminolevulinic acid A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS. antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) dermatologic drug (Code: CHEBI:50177) prodrug (Code: CHEBI:50266) Porphyrin Precursor (Code: N0000175846) Porphyrinogens (Code: N0000171207) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) 1999-12-03 FDA
Click to view leucine An essential branched-chain amino acid important for hemoglobin formation. None FDA
Click to view aminocaproic acid Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1046) Tissue-type plasminogen activator (Organism: Homo sapiens, class: Enzyme, accessions: P00750, gene: PLAT, swissprot: TPA_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1046) An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. antifibrinolytic drug (Code: CHEBI:48675) hematologic agent (Code: CHEBI:50248) Antifibrinolytic Agent (Code: N0000175634) Decreased Fibrinolysis (Code: N0000175632) Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) 1964-06-03 FDA
Click to view paraldehyde A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9) sedative (Code: CHEBI:35717) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993)
Click to view ornithine G-protein coupled receptor family C group 6 member A (Organism: Homo sapiens, class: GPCR, accessions: Q5T6X5, gene: GPRC6A, swissprot: GPC6A_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=725) An amino acid produced in the urea cycle by the splitting off of urea from arginine.
Click to view prenderol None
Click to view aspartic acid Glutamate NMDA receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439|Q00959|Q00960|Q00961|Q62645|Q8VHN2|Q9R1M7, gene: Grin1|Grin2a|Grin2b|Grin2c|Grin2d|Grin3a|Grin3b, swissprot: NMD3A_RAT|NMD3B_RAT|NMDE1_RAT|NMDE2_RAT|NMDE3_RAT|NMDE4_RAT|NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL274323) Aspartate--tRNA ligase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P14868, gene: DARS, swissprot: SYDC_HUMAN) None (Source: WOMBAT-PK) Aspartyl/asparaginyl beta-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: Q12797, gene: ASPH, swissprot: ASPH_HUMAN) None (Source: WOMBAT-PK) Aspartate aminotransferase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00505, gene: GOT2, swissprot: AATM_HUMAN) None (Source: WOMBAT-PK) Aminoacylase-1 (Organism: Homo sapiens, class: Enzyme, accessions: Q03154, gene: ACY1, swissprot: ACY1_HUMAN) None (Source: WOMBAT-PK) Argininosuccinate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P00966, gene: ASS1, swissprot: ASSY_HUMAN) None (Source: WOMBAT-PK) Asparagine synthetase [glutamine-hydrolyzing] (Organism: Homo sapiens, class: Enzyme, accessions: P08243, gene: ASNS, swissprot: ASNS_HUMAN) None (Source: WOMBAT-PK) Aspartoacylase (Organism: Homo sapiens, class: Enzyme, accessions: P45381, gene: ASPA, swissprot: ACY2_HUMAN) None (Source: WOMBAT-PK) Aspartate aminotransferase, cytoplasmic (Organism: Homo sapiens, class: Enzyme, accessions: P17174, gene: GOT1, swissprot: AATC_HUMAN) None (Source: WOMBAT-PK) Calcium-binding mitochondrial carrier protein Aralar1 (Organism: Homo sapiens, class: Unclassified, accessions: O75746, gene: SLC25A12, swissprot: CMC1_HUMAN) None (Source: WOMBAT-PK) Calcium-binding mitochondrial carrier protein Aralar2 (Organism: Homo sapiens, class: Unclassified, accessions: Q9UJS0, gene: SLC25A13, swissprot: CMC2_HUMAN) None (Source: WOMBAT-PK) One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. None FDA
Click to view timonacic None hepatoprotective agent (Code: CHEBI:62868) antidote (Code: CHEBI:50247) 1SAV
2WW7
5FF3
5UU2
5UU4
Click to view tranylcypromine Cationic trypsin (Organism: Bos taurus, class: Enzyme, accessions: P00760, gene: None, swissprot: TRY1_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) Lysine-specific histone demethylase 1A (Organism: Homo sapiens, class: Enzyme, accessions: O60341, gene: KDM1A, swissprot: KDM1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) Cytochrome P450 2A6 (Organism: Homo sapiens, class: Enzyme, accessions: P11509, gene: CYP2A6, swissprot: CP2A6_HUMAN) None (Source: WOMBAT-PK) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: PDSP) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) Lysine-specific histone demethylase 1B (Organism: Homo sapiens, class: Enzyme, accessions: Q8NB78, gene: KDM1B, swissprot: KDM1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1179) A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) antidepressant (Code: CHEBI:35469) anxiolytic drug (Code: CHEBI:35474) Monoamine Oxidase Inhibitor (Code: N0000175744) Anti-Anxiety Agents (Code: D014151) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) 1961-02-21 FDA 3MDR
Click to view adenine Phosphatidylinositol 4-kinase, PI4K (Organism: Homo sapiens, class: Kinase, accessions: P42356|Q8TCG2|Q9BTU6|Q9UBF8, gene: PI4K2A|PI4K2B|PI4KA|PI4KB, swissprot: P4K2A_HUMAN|P4K2B_HUMAN|PI4KA_HUMAN|PI4KB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL226345) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL226345) A purine base and a fundamental unit of ADENINE NUCLEOTIDES. None FDA
Click to view acetanilide a phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term analgesic (Code: CHEBI:35480)
Click to view levamfetamine Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19393) None 2AOF
2AOH
2AOI
2AOJ
Click to view dexamfetamine Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) releasing agent (Source: WOMBAT-PK) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Synaptic vesicular amine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q05940, gene: SLC18A2, swissprot: VMAT2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL612) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: WOMBAT-PK) Cocaine- and amphetamine-regulated transcript protein (Organism: Homo sapiens, class: Transcription factor, accessions: Q16568, gene: CARTPT, swissprot: CART_HUMAN) None (Source: WOMBAT-PK) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: WOMBAT-PK) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: WOMBAT-PK) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2147) The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic. Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) 1955-09-09 FDA 4LAR
4XP9
Click to view amfetamine Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22037049) Serotonin 1 (5-HT1) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19327|P28564|P28565|P30940, gene: Htr1a|Htr1b|Htr1d|Htr1f, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Sodium-dependent serotonin transporter (Organism: Mus musculus, class: Transporter, accessions: Q60857, gene: Slc6a4, swissprot: SC6A4_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q63380, gene: NET, swissprot: Q63380_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) 5-hydroxytryptamine receptor 2B (Organism: Rattus norvegicus, class: GPCR, accessions: P30994, gene: Htr2b, swissprot: 5HT2B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Serotonin 2 (5-HT2) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P30994, gene: Htr2a|Htr2b|Htr2c, swissprot: 5HT2A_RAT|5HT2B_RAT|5HT2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Sodium-dependent noradrenaline transporter (Organism: Mus musculus, class: Transporter, accessions: O55192, gene: Slc6a2, swissprot: SC6A2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) releasing agent (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL405) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) releasing agent (Source: PDSP) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: PDSP) Cocaine- and amphetamine-regulated transcript protein (Organism: Homo sapiens, class: Transcription factor, accessions: Q16568, gene: CARTPT, swissprot: CART_HUMAN) None (Source: WOMBAT-PK) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: WOMBAT-PK) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: WOMBAT-PK) A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. sympathomimetic agent (Code: CHEBI:35524) dopaminergic agent (Code: CHEBI:48560) adrenergic agent (Code: CHEBI:37962) dopamine uptake inhibitor (Code: CHEBI:51039) adrenergic uptake inhibitor (Code: CHEBI:35640) bronchodilator agent (Code: CHEBI:35523) Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 1955-09-09 FDA 2AOF
2AOH
2AOI
2AOJ
4LAR
4XP9
Click to view allopurinol Xanthine dehydrogenase/oxidase (Organism: Bos taurus, class: Enzyme, accessions: P80457, gene: XDH, swissprot: XDH_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1467) Xanthine dehydrogenase/oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22985, gene: Xdh, swissprot: XDH_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1467) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1467) Hypoxanthine-guanine phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P00492, gene: HPRT1, swissprot: HPRT_HUMAN) None (Source: WOMBAT-PK) A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms. gout suppressant (Code: CHEBI:35845) Antimetabolites (Code: D000963) Antioxidants (Code: D000975) Antirheumatic Agents (Code: D018501) Enzyme Inhibitors (Code: D004791) Free Radical Scavengers (Code: D016166) Gout Suppressants (Code: D006074) Noxae (Code: D009676) Xanthine Oxidase Inhibitor (Code: N0000175698) Xanthine Oxidase Inhibitors (Code: N0000000206) 1966-08-19 FDA
Click to view pentaerythritol None 4RMF
Click to view phenylpropanol None
Click to view phenelzine Membrane primary amine oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q16853, gene: AOC3, swissprot: AOC3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Lysine-specific histone demethylase 1A (Organism: Homo sapiens, class: Enzyme, accessions: O60341, gene: KDM1A, swissprot: KDM1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7266) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: DRUG MATRIX) Cytochrome P450 2D6 (Organism: Homo sapiens, class: Enzyme, accessions: P10635, gene: CYP2D6, swissprot: CP2D6_HUMAN) None (Source: DRUG MATRIX) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: DRUG MATRIX) Cytochrome P450 2C19 (Organism: Homo sapiens, class: Enzyme, accessions: P33261, gene: CYP2C19, swissprot: CP2CJ_HUMAN) None (Source: DRUG MATRIX) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1089) Cytochrome P450 2C8 (Organism: Homo sapiens, class: Enzyme, accessions: P10632, gene: CYP2C8, swissprot: CP2C8_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7266) One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC. Monoamine Oxidase Inhibitor (Code: N0000175744) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) 1961-06-09 FDA
Click to view betahistine Histamine H3 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: Q9QYN8, gene: Hrh3, swissprot: HRH3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL24441) Histamine H3 receptor (Organism: Homo sapiens, class: GPCR, accessions: Q9Y5N1, gene: HRH3, swissprot: HRH3_HUMAN) inverse agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/20530654) A histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. H1-receptor agonist (Code: CHEBI:71173) vasodilator agent (Code: CHEBI:35620) Cardiovascular Agents (Code: D002317) Histamine Agents (Code: D018494) Histamine Agonists (Code: D017442) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665)
Click to view isopromethazine None
Click to view homonicotinic acid Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1590) None
Click to view bethanechol Muscarinic acetylcholine receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8VH26, gene: GPM3, swissprot: Q8VH26_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1482) Muscarinic receptor 2 (Organism: Cavia porcellus, class: Unclassified, accessions: Q8VH27, gene: GPM2, swissprot: Q8VH27_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1482) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=297) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=297) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=297) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=297) A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM. muscarinic agonist (Code: CHEBI:38325) Cholinergic Muscarinic Agonist (Code: N0000175840) Cholinergic Muscarinic Agonists (Code: N0000000104) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) 1948-10-12 FDA
Click to view methyl nicotinate erythema provoked is basis of a methylnicotinate test of anti-inflammatories None FDA
Click to view salicylamide It blocks cyclooxygenase, breaks the metabolism of arachidonic acid, reduces the amount of prostaglandins both in the inflammation focus and in healthy tissues, suppresses the exudative and proliferative phase of inflammation. Reduces the permeability of capillaries; stabilizes the lysosomal membranes; inhibits the production of macroergers (primarily ATP) in the processes of oxidative phosphorylation; inhibits synthesis or inactivates mediators of inflammation, incl. histamine, bradykinin, lymphokines, complement factor and other nonspecific endogenous "damaging factors". It blocks the interaction of bradykinin with tissue receptors, restores disturbed microcirculation and reduces pain sensitivity in the inflammatory focus non-narcotic analgesic (Code: CHEBI:35481) antirheumatic drug (Code: CHEBI:35842) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1964-04-30 Ministry of Health of the Russian Federation 4K17
Click to view aminobenzoic acid Acetylcholinesterase (Organism: Rattus norvegicus, class: Enzyme, accessions: P37136, gene: Ache, swissprot: ACES_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL542) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL542) Dihydropteroate synthase (Organism: Bacillus anthracis, class: Enzyme, accessions: Q81VW8, gene: folP, swissprot: Q81VW8_BACAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL542) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL542) An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS. Vitamin B Complex Compounds (Code: N0000175715) Vitamin B Complex Member (Code: N0000175714) 2006-07-28 Ministry of Health of the Russian Federation 1IUS
1IUT
1IUU
1PBD
2DZA
3Q2A
3TYZ
5UUR
Click to view isoniazid Catalase-peroxidase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WIE4, gene: katG, swissprot: KATG_MYCTO) None (Source: WOMBAT-PK) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) inhibitor (Source: WOMBAT-PK) Dihydrofolate reductase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WNX1, gene: folA, swissprot: DYR_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL64) Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: WOMBAT-PK) Cytochrome P450 3A5 (Organism: Homo sapiens, class: Enzyme, accessions: P20815, gene: CYP3A5, swissprot: CP3A5_HUMAN) None (Source: WOMBAT-PK) Antibacterial agent used primarily as a tuberculostatic, inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. It remains the treatment of choice for tuberculosis drug allergen (Code: CHEBI:88188) antitubercular agent (Code: CHEBI:33231) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) 1952-09-29 FDA 3WXO
4PAE
5KSG
5KSN
5KT8
5SXQ
5SXS
5SXT
5SYI
5SYJ
6CDQ
6CFQ
Click to view dimetofrine proposed cardiovascular stimulant; minor descriptor (75-85); on-line & Index Medicus search ETHANOLAMINES (75-85); RN given refers to parent cpd without isomeric designation
Click to view pralidoxime Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) activator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL748) The principal ation of pralidoxime is to reactivate cholinesterase (mainly outside the central nervous system) which has been inactivated by phosphorylation due to an organophosphorus nerve agent or related compound cholinergic drug (Code: CHEBI:38323) antidote to organophosphate poisoning (Code: CHEBI:90753) antidote to sarin poisoning (Code: CHEBI:136860) Cholinesterase Reactivator (Code: N0000175742) Antidotes (Code: D000931) Cholinergic Agents (Code: D018678) Cholinesterase Reactivators (Code: D002801) Enzyme Reactivators (Code: D004793) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) 1964-03-11 FDA
Click to view phenylethanolamine None
Click to view tyramine 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL11608) TyR1 (Organism: Chilo suppressalis, class: GPCR, accessions: H9TVJ1, gene: None, swissprot: H9TVJ1_9NEOP) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL11608) Serotonin (5-HT) receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08909|P14842|P19327|P28564|P28565|P30940|P30994|P31388|P32305|P35364|P35365|P35563|Q62758|Q9JJ16, gene: Htr1a|Htr1b|Htr1d|Htr1f|Htr2a|Htr2b|Htr2c|Htr3a|Htr3b|Htr4|Htr5a|Htr5b|Htr6|Htr7, swissprot: 5HT1A_RAT|5HT1B_RAT|5HT1D_RAT|5HT1F_RAT|5HT2A_RAT|5HT2B_RAT|5HT2C_RAT|5HT3A_RAT|5HT3B_RAT|5HT4R_RAT|5HT5A_RAT|5HT5B_RAT|5HT6R_RAT|5HT7R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL11608) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL11608) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: WOMBAT-PK) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2150) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2150) An indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems. Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 3BRA
4N7C
5FF9
Click to view isaxonine promotes nerve growth
Click to view fosfomycin UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (Organism: Enterococcus faecalis (strain ATCC 700802 / V583), class: Enzyme, accessions: Q836E5, gene: murA1, swissprot: MURA1_ENTFA) None (Source: WOMBAT-PK) UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (Organism: Enterococcus faecalis (strain ATCC 700802 / V583), class: Enzyme, accessions: Q831A8, gene: murA2, swissprot: MURA2_ENTFA) None (Source: WOMBAT-PK) UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0A749, gene: murA, swissprot: MURA_ECOLI) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1757) UDP-N-acetylglucosamine 1-carboxyvinyltransferase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Unclassified, accessions: Q9HVW7, gene: murA, swissprot: MURA_PSEAE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1757) An antibiotic produced by Streptomyces fradiae. Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) 1996-12-19 FDA 1LQP
2BNN
3D41
3QUO
4IR0
4JD1
4JH3
4JH4
4JH5
4JH6
4JH8
5V3D
Click to view salicylic acid Salicylic acid-binding protein 2 (Organism: Nicotiana tabacum, class: Enzyme, accessions: Q6RYA0, gene: SABP2, swissprot: SABP2_TOBAC) None (Source: WOMBAT-PK) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Solute carrier family 22 member 20 (Organism: Mus musculus, class: Transporter, accessions: Q80UJ1, gene: Slc22a20, swissprot: S22AK_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL424) A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions. antiinfective agent (Code: CHEBI:35441) keratolytic drug (Code: CHEBI:50176) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Infective Agents (Code: D000890) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antifungal Agents (Code: D000935) Antirheumatic Agents (Code: D018501) Cyclooxygenase Inhibitors (Code: D016861) Dermatologic Agents (Code: D003879) Enzyme Inhibitors (Code: D004791) Keratolytic Agents (Code: D007641) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1898-01-01 YEAR INTRODUCED 1FIQ
1FO4
1JGS
1M6E
1PTH
1WYG
1Y7I
2E1Q
2FN1
2I2Z
2I30
2Y7K
2Y7P
2Y7W
3AX7
3AX9
3B9M
3BPX
3DEU
3GF2
3HGX
3KP6
3N8Y
3NJZ
3NVC
3REM
3RET
3TWP
3UNA
3UNC
3UNI
3W1W
3ZMD
4EM0
4EM2
4EQ4
4EQL
4HVR
4L39
4Y03
5EVY
5F1A
5M78
5OF1
5SWR
5U6M
5U6N
5X80
Click to view phenoxyethanol None antiinfective agent (Code: CHEBI:35441) central nervous system depressant (Code: CHEBI:35488) Anesthetics (Code: D000777) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) None FDA 2RBR
Click to view pentetrazol A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility. Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) GABA Agents (Code: D018682) GABA Antagonists (Code: D018756) Neurotransmitter Agents (Code: D018377) 2015-11-11 EMA
Click to view methazolamide Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Homo sapiens, class: Enzyme, accessions: O43570|P00915|P00918|P07451|P22748|P23280|P35218|P43166|Q16790|Q8N1Q1|Q9ULX7|Q9Y2D0, gene: CA1|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9, swissprot: CAH12_HUMAN|CAH13_HUMAN|CAH14_HUMAN|CAH1_HUMAN|CAH2_HUMAN|CAH3_HUMAN|CAH4_HUMAN|CAH5A_HUMAN|CAH5B_HUMAN|CAH6_HUMAN|CAH7_HUMAN|CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase V (Organism: Homo sapiens, class: Enzyme, accessions: P35218|Q9Y2D0, gene: CA5A|CA5B, swissprot: CAH5A_HUMAN|CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) Carbonic anhydrase (Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65), class: Enzyme, accessions: Q6FTL6, gene: None, swissprot: Q6FTL6_CANGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL19) A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. Carbonic Anhydrase Inhibitors (Code: D002257) Diuretics (Code: D004232) Enzyme Inhibitors (Code: D004791) Natriuretic Agents (Code: D045283) 1959-01-26 FDA 1BZM
3DAZ
3DCS
4K0Z
4YHA
5C8I
5KU6
Click to view irofulven Serine/threonine-protein kinase Chk2 (Organism: Homo sapiens, class: Kinase, accessions: O96017, gene: CHEK2, swissprot: CHK2_HUMAN) None (Source: WOMBAT-PK) None Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) Radiation-Sensitizing Agents (Code: D011838)
Click to view methenamine An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Urinary (Code: D000892) Renal Agents (Code: D012076) 1967-07-05 FDA
Click to view furtrethonium None Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Neurotransmitter Agents (Code: D018377)
Click to view ethosuximide Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) blocker (Source: WOMBAT-PK) An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) 1960-11-02 FDA
Click to view isometheptene None None FDA
Click to view cyclopentamine None
Click to view metyrapone Cytochrome P450 3A4 (Organism: Homo sapiens, class: Enzyme, accessions: P08684, gene: CYP3A4, swissprot: CP3A4_HUMAN) None (Source: DRUG MATRIX) Cytochrome P450 11B1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P15538, gene: CYP11B1, swissprot: C11B1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL934) Cytochrome P450 11B1 (Organism: Bos taurus, class: Unclassified, accessions: P15150, gene: CYP11B1, swissprot: C11B1_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL934) Cytochrome P450 11B2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P19099, gene: CYP11B2, swissprot: C11B2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL934) Cytochrome P450 11B1, mitochondrial (Organism: Rattus norvegicus, class: Unclassified, accessions: P15393, gene: Cyp11b1, swissprot: C11B1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL934) An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. diagnostic agent (Code: CHEBI:33295) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Noxae (Code: D009676) Adrenal Steroid Synthesis Inhibitor (Code: N0000175928) Adrenal Steroid Synthesis Inhibitors (Code: N0000175921) 1961-12-04 FDA 1PHG
1W0G
4ZF8
Click to view kojic acid D-amino-acid oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P14920, gene: DAO, swissprot: OXDA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL287556) D-amino-acid oxidase (Organism: Sus scrofa, class: Unclassified, accessions: P00371, gene: DAO, swissprot: OXDA_PIG) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL287556) Tyrosinase (Organism: Mus musculus, class: Unclassified, accessions: P11344, gene: Tyr, swissprot: TYRO_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL287556) Polyphenol oxidase 2 (Organism: Agaricus bisporus, class: Enzyme, accessions: O42713, gene: PPO2, swissprot: PPO2_AGABI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL287556) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL287556) None skin lightening agent (Code: CHEBI:85046) Antioxidants (Code: D000975) Protective Agents (Code: D020011) 1GQH
3NQ1
5I38
5M8M
5M8Q
Click to view piracetam A compound suggested to be both a nootropic and a neuroprotective agent. Central Nervous System Agents (Code: D002491) Neuroprotective Agents (Code: D018696) Nootropic Agents (Code: D018697) Protective Agents (Code: D020011) 1972-01-01 YEAR INTRODUCED 3LSF
3LSL
3LSX
Click to view methylthiouracil A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism. Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730)
Click to view mesna A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE. The first step in the detoxification process is the binding of mesna to 4-hydroxyifosfamide forming a non-urotoxic 4-sulfoethylthioifosfamide. Mesna also binds to the double bonds of acrolein and to other urotoxic metabolites and inhibits their effects on the bladder Protective Agents (Code: D020011) 1988-12-30 FDA
Click to view trimethadione Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) blocker (Source: WOMBAT-PK) An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) 1946-01-25 FDA
Click to view valpromide None Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) 1NU3
2CJP
3G0I
5AIG
Click to view valnoctamide None
Click to view betanaphthol None antinematodal drug (Code: CHEBI:35444) 3U3K
4B32
Click to view trichloroacetic acid A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts. Caustics (Code: D002424) Noxae (Code: D009676) None FDA
Click to view octanoic acid None 1H2B
1U8U
1V2G
2BUI
2EUM
2QHS
2WG9
3L91
3NQ9
3WL8
4RW3
4RW5
5EFI
5F2K
5KP2
5TID
5TIE
5TIF
5X52
Click to view valproic acid Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Alcohol dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: P14550, gene: AKR1A1, swissprot: AK1A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Alcohol dehydrogenase [NADP(+)] (Organism: Sus scrofa, class: Enzyme, accessions: P50578, gene: AKR1A1, swissprot: AK1A1_PIG) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Alcohol dehydrogenase [NADP(+)] (Organism: Rattus norvegicus, class: Enzyme, accessions: P51635, gene: Akr1a1, swissprot: AK1A1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Succinate-semialdehyde dehydrogenase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P51649, gene: ALDH5A1, swissprot: SSDH_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) UDP-glucuronosyltransferase 1-5 (Organism: Homo sapiens, class: Enzyme, accessions: P35504, gene: UGT1A5, swissprot: UD15_HUMAN) None (Source: WOMBAT-PK) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7009) Aldose reductase (Organism: Bos taurus, class: Enzyme, accessions: P16116, gene: AKR1B1, swissprot: ALDR_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) Aldose reductase-related protein 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q5RJP0, gene: Akr1b7, swissprot: ALD1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL109) A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels. GABA agent (Code: CHEBI:51374) anticonvulsant (Code: CHEBI:35623) psychotropic drug (Code: CHEBI:35471) neuroprotective agent (Code: CHEBI:63726) antimanic drug (Code: CHEBI:35477) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Mood Stabilizer (Code: N0000175751) Anticonvulsants (Code: D000927) Antimanic Agents (Code: D018692) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Enzyme Inhibitors (Code: D004791) GABA Agents (Code: D018682) Neurotransmitter Agents (Code: D018377) Psychotropic Drugs (Code: D011619) Tranquilizing Agents (Code: D014149) 1978-02-28 FDA 1DIT
Click to view octamoxin None
Click to view ethchlorvynol GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive modulator (Source: WOMBAT-PK) A sedative and hypnotic that has been used in the short-term management of INSOMNIA. Its use has been superseded by other drugs. sedative (Code: CHEBI:35717) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) 1961-05-10 FDA
Click to view methyl aminolevulinate None antineoplastic agent (Code: CHEBI:35610) photosensitizing agent (Code: CHEBI:47868) prodrug (Code: CHEBI:50266) dermatologic drug (Code: CHEBI:50177) Porphyrin Precursor (Code: N0000175846) Porphyrinogens (Code: N0000171207) 2004-07-27 FDA
Click to view oxyquinoline 72 kDa type IV collagenase (Organism: Homo sapiens, class: Enzyme, accessions: P08253, gene: MMP2, swissprot: MMP2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL310555) Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL310555) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL310555) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL310555) Bacterial leucyl aminopeptidase (Organism: Vibrio proteolyticus, class: Enzyme, accessions: Q01693, gene: None, swissprot: AMPX_VIBPR) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL310555) An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics. antiseptic drug (Code: CHEBI:48218) antifungal agrochemical (Code: CHEBI:86328) 1985-12-24 FDA 3KCY
3VH9
4JFG
Click to view emylcamate
Click to view heptaminol An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.
Click to view trioxsalen Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: DRUG MATRIX) Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo. dermatologic drug (Code: CHEBI:50177) photosensitizing agent (Code: CHEBI:47868) Psoralen (Code: N0000175879) Psoralens (Code: N0000007909) Dermatologic Agents (Code: D003879) Photosensitizing Agents (Code: D017319) Radiation-Sensitizing Agents (Code: D011838) 1964-07-24 FDA
Click to view gimeracil Dihydropyrimidine dehydrogenase [NADP(+)] (Organism: Homo sapiens, class: Enzyme, accessions: Q12882, gene: DPYD, swissprot: DPYD_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/21668582) a biochemical and pharmacological modulator of 5-FU 2011-03-14 EMA
Click to view adipic acid Solute carrier family 22 member 6 (Organism: Mus musculus, class: Transporter, accessions: Q8VC69, gene: Slc22a6, swissprot: S22A6_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1157) None food acidity regulator (Code: CHEBI:64049) 4DHW
4JT0
4UTZ
5D2J
5OKU
Click to view isosorbide 1,4:3,6-Dianhydro D-glucitol. Chemically inert osmotic diuretic used mainly to treat hydrocephalus; also used in glaucoma. Diuretics (Code: D004232) Diuretics, Osmotic (Code: D004234) Natriuretic Agents (Code: D045283) 1974-01-30 FDA
Click to view coumarin Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL6466) effective in reducing edema following crush & thermal injury; structure in Merck Index, 9th ed, #2547; Coumarin itself occurs in the Tonka bean fluorescent dye (Code: CHEBI:51121) 1Z10
2H90
2PMJ
2PWB
3CRB
3L5M
3L66
3L68
4UTI
4UTL
Click to view glutamine A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. Amino Acid (Code: N0000175780) Amino Acids (Code: N0000006806) 2004-06-10 FDA
Click to view acetylpheneturide None
Click to view lysine Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL8085) An essential amino acid. It is often added to animal feed. nutraceutical (Code: CHEBI:50733) anticonvulsant (Code: CHEBI:35623) None FDA
Click to view oxapropanium None
Click to view acetylcholine Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Nicotinic acetylcholine receptor alpha8 subunit (Organism: Periplaneta americana, class: Unclassified, accessions: H6TY12, gene: None, swissprot: H6TY12_PERAM) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Acetylcholine-binding protein (Organism: Lymnaea stagnalis, class: Unclassified, accessions: P58154, gene: None, swissprot: ACHP_LYMST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL667) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=294) A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. vasodilator agent (Code: CHEBI:35620) muscarinic agonist (Code: CHEBI:38325) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) Cholinergic Receptor Agonist (Code: N0000175884) 1973-10-09 FDA 2ACE
2HA4
2J0H
2RIN
2XZ5
3Q5S
3RQW
3WIP
Click to view trientine copper (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.ncbi.nlm.nih.gov/pubmed/6121964) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL609) An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION. Metal Chelating Activity (Code: N0000175472) Metal Chelator (Code: N0000175473) Chelating Agents (Code: D002614) Sequestering Agents (Code: D064449) 1985-11-08 FDA 1DJ6
Click to view ambazone Bacteriostatic action on hemolytic streptococcus, Streptococcus pneumoniae and viridans streptococci. 2010-05-17 Ministry of Health of the Russian Federation
Click to view glutamic acid Metabotropic glutamate receptor 8 (Organism: Homo sapiens, class: GPCR, accessions: O00222, gene: GRM8, swissprot: GRM8_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369) Metabotropic glutamate receptor 3 (Organism: Homo sapiens, class: GPCR, accessions: Q14832, gene: GRM3, swissprot: GRM3_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1369) Glutamate dehydrogenase 2, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P49448, gene: GLUD2, swissprot: DHE4_HUMAN) None (Source: WOMBAT-PK) Glutamate dehydrogenase 1, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00367, gene: GLUD1, swissprot: DHE3_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor 3 (Organism: Homo sapiens, class: Ion channel, accessions: P42263, gene: GRIA3, swissprot: GRIA3_HUMAN) None (Source: PDSP) Glutamate receptor ionotropic, kainate 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q16099, gene: GRIK4, swissprot: GRIK4_HUMAN) None (Source: PDSP) Metabotropic glutamate receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: Q14831, gene: GRM7, swissprot: GRM7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Excitatory amino acid transporter 3 (Organism: Homo sapiens, class: Transporter, accessions: P43005, gene: SLC1A1, swissprot: EAA3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q13255, gene: GRM1, swissprot: GRM1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q14416, gene: GRM2, swissprot: GRM2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 5 (Organism: Homo sapiens, class: GPCR, accessions: P41594, gene: GRM5, swissprot: GRM5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 1 (Organism: Homo sapiens, class: Ion channel, accessions: P39086, gene: GRIK1, swissprot: GRIK1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 5 (Organism: Homo sapiens, class: Ion channel, accessions: Q16478, gene: GRIK5, swissprot: GRIK5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q13003, gene: GRIK3, swissprot: GRIK3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 4 (Organism: Homo sapiens, class: Ion channel, accessions: P48058, gene: GRIA4, swissprot: GRIA4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: P42262, gene: GRIA2, swissprot: GRIA2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q13002, gene: GRIK2, swissprot: GRIK2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 1 (Organism: Homo sapiens, class: Ion channel, accessions: P42261, gene: GRIA1, swissprot: GRIA1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 4 (Organism: Homo sapiens, class: GPCR, accessions: Q14833, gene: GRM4, swissprot: GRM4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 6 (Organism: Homo sapiens, class: GPCR, accessions: O15303, gene: GRM6, swissprot: GRM6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Excitatory amino acid transporter 1 (Organism: Homo sapiens, class: Transporter, accessions: P43003, gene: SLC1A3, swissprot: EAA1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Excitatory amino acid transporter 2 (Organism: Homo sapiens, class: Transporter, accessions: P43004, gene: SLC1A2, swissprot: EAA2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19490, gene: Gria1, swissprot: GRIA1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19491, gene: Gria2, swissprot: GRIA2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19492, gene: Gria3, swissprot: GRIA3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor 4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P19493, gene: Gria4, swissprot: GRIA4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P22756, gene: Grik1, swissprot: GRIK1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: P23385, gene: Grm1, swissprot: GRM1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31421, gene: Grm2, swissprot: GRM2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31422, gene: Grm3, swissprot: GRM3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 4 (Organism: Rattus norvegicus, class: GPCR, accessions: P31423, gene: Grm4, swissprot: GRM4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 5 (Organism: Rattus norvegicus, class: Unclassified, accessions: P31424, gene: Grm5, swissprot: GRM5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 6 (Organism: Rattus norvegicus, class: GPCR, accessions: P35349, gene: Grm6, swissprot: GRM6_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, NMDA 1 (Organism: Rattus norvegicus, class: Ion channel, accessions: P35439, gene: Grin1, swissprot: NMDZ1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42260, gene: Grik2, swissprot: GRIK2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate receptor ionotropic, kainate 3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P42264, gene: Grik3, swissprot: GRIK3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 8 (Organism: Mus musculus, class: Unclassified, accessions: P47743, gene: Grm8, swissprot: GRM8_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Metabotropic glutamate receptor 8 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70579, gene: Grm8, swissprot: GRM8_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate racemase (Organism: Lactobacillus fermentum, class: Unclassified, accessions: Q03469, gene: murI, swissprot: MURI_LACFE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) Glutamate racemase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Unclassified, accessions: P56068, gene: murI, swissprot: MURI_HELPY) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL76232) A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. 1985 FDA
Click to view meldonium Gamma-butyrobetaine dioxygenase (Organism: Homo sapiens, class: Enzyme, accessions: O75936, gene: BBOX1, swissprot: BODG_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL2104708) structural analog of gamma-butyrobetaine, also of carnitine; antianginal compound; MET-88 is dihydrate; structure given in first source cardioprotective agent (Code: CHEBI:77307) neuroprotective agent (Code: CHEBI:63726) 2006 Ministry of Health of the Russian Federation
Click to view carbachol Muscarinic acetylcholine receptor M5 (Organism: Homo sapiens, class: GPCR, accessions: P08912, gene: CHRM5, swissprot: ACM5_HUMAN) None (Source: WOMBAT-PK) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: WOMBAT-PK) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: WOMBAT-PK) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor (Organism: Cavia porcellus, class: GPCR, accessions: Q8VH26, gene: GPM3, swissprot: Q8VH26_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M2 (Organism: Mus musculus, class: GPCR, accessions: Q9ERZ4, gene: Chrm2, swissprot: ACM2_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M1 (Organism: Mus musculus, class: GPCR, accessions: P12657, gene: Chrm1, swissprot: ACM1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL14) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: WOMBAT-PK) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: WOMBAT-PK) A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS. nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) muscarinic agonist (Code: CHEBI:38325) cardiotonic drug (Code: CHEBI:38147) miotic (Code: CHEBI:51068) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Miotics (Code: D008916) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sensory System Agents (Code: D018689) 1972-09-28 FDA 1UV6
Click to view ketoxal modifies guanine containing oligoribonucleotides by reacting selectively with guanine in polynucleotides; structure Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998)
Click to view viloxazine Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) Sodium-dependent serotonin transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P31652, gene: Slc6a4, swissprot: SC6A4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL251072) A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE. Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Antidepressive Agents (Code: D000928) Antidepressive Agents, Second-Generation (Code: D018687) Central Nervous System Agents (Code: D002491) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Psychotropic Drugs (Code: D011619)
Click to view trolamine None 1958 FDA 2HMP
3FRL
3H7C
3RQ0
3ZUK
5CIX
Click to view methionine S-ribosylhomocysteine lyase (Organism: Bacillus subtilis (strain 168), class: Unclassified, accessions: O34667, gene: luxS, swissprot: LUXS_BACSU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL42336) A sulfur-containing essential L-amino acid that is important in many body functions. 1975 FDA
Click to view penicillamine copper (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/19853s012,014lbl.pdf) Succinyl-diaminopimelate desuccinylase (Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd), class: Enzyme, accessions: P44514, gene: dapE, swissprot: DAPE_HAEIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1430) 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease. antirheumatic drug (Code: CHEBI:35842) Antidotes (Code: D000931) Antirheumatic Agents (Code: D018501) Chelating Agents (Code: D002614) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) Antirheumatic Agent (Code: N0000175713) 1970-12-04 FDA 3H5G
Click to view phenpromethamine None
Click to view tioxolone Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL442687) antiseborrheic agent antiseborrheic (Code: CHEBI:59010)
Click to view phentermine Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: WOMBAT-PK) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: WOMBAT-PK) A central nervous system stimulant and sympathomimetic with actions and uses similar to those of DEXTROAMPHETAMINE. It has been used most frequently in the treatment of obesity. dopaminergic agent (Code: CHEBI:48560) adrenergic agent (Code: CHEBI:37962) sympathomimetic agent (Code: CHEBI:35524) appetite depressant (Code: CHEBI:50507) central nervous system drug (Code: CHEBI:35470) central nervous system stimulant (Code: CHEBI:35337) Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Adrenergic Agents (Code: D018663) Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 1959-05-04 FDA
Click to view isocarboxazid Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1201168) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1201168) An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311) Monoamine Oxidase Inhibitor (Code: N0000175744) Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619) 1959-07-01 FDA
Click to view methamphetamine Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Trace amine-associated receptor 1 (Organism: Macaca mulatta, class: GPCR, accessions: Q8HZ64, gene: TAAR1, swissprot: TAAR1_MACMU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Synaptic vesicular amine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q01827, gene: Slc18a2, swissprot: VMAT2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200952) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: PDSP) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: PDSP) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) inhibitor (Source: PDSP) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: PDSP) A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed. psychotropic drug (Code: CHEBI:35471) central nervous system stimulant (Code: CHEBI:35337) Amphetamine Anorectic (Code: N0000175425) Amphetamines (Code: N0000007883) Appetite Suppression (Code: N0000175372) Central Nervous System Stimulation (Code: N0000175729) Increased Sympathetic Activity (Code: N0000175651) Adrenergic Agents (Code: D018663) Adrenergic Uptake Inhibitors (Code: D018759) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 1943-12-31 FDA 3GKZ
4GQP
4XP6
Click to view ditiocarb Carbonic anhydrase 1; GH09688p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9V396, gene: CAH1, swissprot: Q9V396_DROME) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 2, isoform A; LD26647p (Organism: Drosophila melanogaster, class: Enzyme, accessions: Q9VTU8, gene: CAH2, swissprot: Q9VTU8_DROME) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL961) A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM. Adjuvants, Immunologic (Code: D000276) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Chelating Agents (Code: D002614) Immunologic Factors (Code: D007155) Sequestering Agents (Code: D064449)
Click to view tartaric acid None 1985-08-07 FDA 5UC7
Click to view moroxydine None Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998)
Click to view xylose None 1987-03-26 FDA
Click to view levofacetoperane None
Click to view cresatin None
Click to view paroxypropione None
Click to view pheniprazine Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17404836) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/17404836) Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.
Click to view ethylmethylthiambutene None
Click to view paracetamol Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Arachidonate 5-lipoxygenase-activating protein (Organism: Homo sapiens, class: Cytosolic other, accessions: P20292, gene: ALOX5AP, swissprot: AL5AP_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Myoglobin (Organism: Homo sapiens, class: Unclassified, accessions: P02144, gene: MB, swissprot: MYG_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL112) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Cannabinoid receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: P21554, gene: CNR1, swissprot: CNR1_HUMAN) agonist (Source: WOMBAT-PK) Transient receptor potential cation channel subfamily V member 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q8NER1, gene: TRPV1, swissprot: TRPV1_HUMAN) opener (Source: WOMBAT-PK) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: WOMBAT-PK) Nuclear receptor subfamily 1 group I member 3 (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: Q14994, gene: NR1I3, swissprot: NR1I3_HUMAN) None (Source: WOMBAT-PK) Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. non-narcotic analgesic (Code: CHEBI:35481) antipyretic (Code: CHEBI:35493) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Antipyretics (Code: D058633) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1968-11-07 FDA 1TYL
1TYM
2DPZ
2OCU
3PY4
4A9J
4A9K
4CUT
4GN6
4YJI
5PBE
Click to view aminomethylbenzoic acid an antifibrinolytic Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Protease Inhibitors (Code: D011480) 1983-08-04 Ministry of Health of the Russian Federation
Click to view phenicarbazide None
Click to view cathine major metabolite of diethylpropion in man under acidic urine conditions; RN given refers to cpd without isomeric designation Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Central Nervous System Agents (Code: D002491)
Click to view phenylpropanolamine Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL61006) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL61006) Alpha-1D adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P23944, gene: Adra1d, swissprot: ADA1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL61006) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL61006) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: WOMBAT-PK) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: PDSP) 5-hydroxytryptamine receptor 7 (Organism: Homo sapiens, class: GPCR, accessions: P34969, gene: HTR7, swissprot: 5HT7R_HUMAN) None (Source: PDSP) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: WOMBAT-PK) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL61006) A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant. Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 2000-09-29 FDA 3U8Q
Click to view hydroxyamfetamine Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/22037049) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1546) Beta-secretase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P56817, gene: BACE1, swissprot: BACE1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1546) Amphetamine metabolite with sympathomimetic effects. It is sometimes called alpha-methyltyramine, which may also refer to the meta isomer, gepefrine. Adrenergic Agonists (Code: N0000000122) Adrenergic Receptor Agonist (Code: N0000175883) 1969-07-16 FDA 3BUF
Click to view gepefrine isomer of PARA-HYDROXYAMPHETAMINE which is also called alpha-methyl-tyramine
Click to view amantadine Matrix protein 2 (Organism: Influenza A virus (A/udorn/1972(H3N2)), class: Unclassified, accessions: Q20MD5, gene: M2, swissprot: Q20MD5_9INFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL660) Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL660) Matrix protein 2 (Organism: Influenza A virus (strain A/Udorn/307/1972 H3N2), class: Ion channel, accessions: P63231, gene: M, swissprot: M2_I72A2) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL660) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL660) Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL660) An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. antiviral drug (Code: CHEBI:36044) antiparkinson drug (Code: CHEBI:48407) dopaminergic agent (Code: CHEBI:48560) analgesic (Code: CHEBI:35480) non-narcotic analgesic (Code: CHEBI:35481) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Dyskinesia Agents (Code: D018726) Anti-Infective Agents (Code: D000890) Antiparkinson Agents (Code: D000978) Antiviral Agents (Code: D000998) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Influenza A M2 Protein Inhibitor (Code: N0000175543) M2 Protein Inhibitors (Code: N0000175542) 1968-02-14 FDA 3C9J
3UIV
Click to view methylparaben Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL325372) used as a preservative in cosmetics but potentiates UV-induced damage of skin; RN given refers to parent cpd antimicrobial food preservative (Code: CHEBI:65256) neuroprotective agent (Code: CHEBI:63726) Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) 2VK0
3MTH
Click to view mandelic acid Dermatologic 1MCZ
1MDL
3TTE
3ZGJ
4P56
Click to view hydroxymethylnicotinamide the amide derivative of nicotinic acid and formaldehyde. Has a choleretic (choleretic) effect, and also promotes the secretion of bile (cholekinetic effect). In addition, it has a bacteriostatic and bactericidal action, which is due to the fact that during the metabolism, the formaldehyde part of the drug molecule is cleaved. The other part of the molecule (nicotinamide) has the properties of vitamin PP, increases the secretory function of the liver parenchyma, enhancing the secretion of bile and facilitating its entry into the intestine. The drug is used in complex treatment violations of the liver, with cholecystitis, as well as infections of the urinary tract and gastroenteritis. It is effective in the treatment of infections caused by E. coli. 1964-04-30 Ministry of Health of the Russian Federation
Click to view tisopurine 4-thio analog of allopurinol; structure Antirheumatic Agents (Code: D018501) Gout Suppressants (Code: D006074)
Click to view debrisoquine Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: WOMBAT-PK) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: WOMBAT-PK) An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. antihypertensive agent (Code: CHEBI:35674) adrenergic agent (Code: CHEBI:37962) sympatholytic agent (Code: CHEBI:66991) Adrenergic Agents (Code: D018663) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) 1965-01-01 YEAR INTRODUCED
Click to view mercaptopurine Purine nucleoside phosphorylase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Unclassified, accessions: P9WP01, gene: punA, swissprot: PUNA_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1425) Amidophosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q06203, gene: PPAT, swissprot: PUR1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1425) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Thiopurine S-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P51580, gene: TPMT, swissprot: TPMT_HUMAN) None (Source: WOMBAT-PK) Purine nucleoside phosphorylase (Organism: Homo sapiens, class: Enzyme, accessions: P00491, gene: PNP, swissprot: PNPH_HUMAN) None (Source: WOMBAT-PK) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) None (Source: WOMBAT-PK) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) None (Source: WOMBAT-PK) An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791) Immunologic Factors (Code: D007155) Immunosuppressive Agents (Code: D007166) Noxae (Code: D009676) Nucleic Acid Synthesis Inhibitors (Code: D019384) 1953-09-11 FDA
Click to view homocamfin None
Click to view camphor Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL504760) Transient receptor potential cation channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BLA8, gene: Trpa1, swissprot: TRPA1_MOUSE) gating inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2422) A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) 1970-11-12 Ministry of Health of the Russian Federation
Click to view aminosalicylic acid 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Kinase, accessions: P9WNC6, gene: folK, swissprot: HPPK_MYCTO) None (Source: WOMBAT-PK) Tyrosine-protein phosphatase non-receptor type 1 (Organism: Homo sapiens, class: Enzyme, accessions: P18031, gene: PTPN1, swissprot: PTN1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1169) Cyclooxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P23219|P35354, gene: PTGS1|PTGS2, swissprot: PGH1_HUMAN|PGH2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1169) An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid. antitubercular agent (Code: CHEBI:33231) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) 1982-01-01 FDA 1PBC
1PBF
1SXK
5X7Z
Click to view mesalazine Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL704) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL704) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: WOMBAT-PK) Peroxisome proliferator-activated receptor gamma (Organism: Homo sapiens, class: Nuclear hormone receptor, accessions: P37231, gene: PPARG, swissprot: PPARG_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2700) An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Aminosalicylate (Code: N0000175781) Aminosalicylic Acids (Code: N0000005760) 1987-12-24 FDA
Click to view octopamine TyR1 (Organism: Chilo suppressalis, class: GPCR, accessions: H9TVJ1, gene: None, swissprot: H9TVJ1_9NEOP) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL53929) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL53929) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2149) Trace amine-associated receptor 1 (Organism: Rattus norvegicus, class: GPCR, accessions: Q923Y9, gene: Taar1, swissprot: TAAR1_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2149) Trace amine-associated receptor 1 (Organism: Mus musculus, class: GPCR, accessions: Q923Y8, gene: Taar1, swissprot: TAAR1_MOUSE) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2149) An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates. Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasoconstrictor Agents (Code: D014662) 1RG1
1RG2
1RGT
1RGU
1RH0
2AN4
3HCA
3HCE
4QJQ
Click to view enbucrilate A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.
Click to view norfenefrine None Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Neurotransmitter Agents (Code: D018377)
Click to view dopamine D(4) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21917, gene: DRD4, swissprot: DRD4_HUMAN) agonist (Source: WOMBAT-PK) D(1B) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21918, gene: DRD5, swissprot: DRD5_HUMAN) agonist (Source: WOMBAT-PK) Dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288|Q95136, gene: DRD1|DRD2, swissprot: DRD1_BOVIN|DRD2_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Adenylate cyclase (Organism: Rattus norvegicus, class: Enzyme, accessions: D4A3N4|P21932|P26769|P26770|P40146|Q03343|Q04400|Q8CFM9, gene: Adcy1|Adcy2|Adcy3|Adcy4|Adcy5|Adcy6|Adcy8, swissprot: ADCY2_RAT|ADCY3_RAT|ADCY4_RAT|ADCY5_RAT|ADCY6_RAT|ADCY8_RAT|D4A3N4_RAT|Q8CFM9_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(1A) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: Q95136, gene: DRD1, swissprot: DRD1_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(4) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P30729, gene: Drd4, swissprot: DRD4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Melatonin receptor type 1A (Organism: Homo sapiens, class: GPCR, accessions: P48039, gene: MTNR1A, swissprot: MTR1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Melatonin receptor type 1B (Organism: Homo sapiens, class: GPCR, accessions: P49286, gene: MTNR1B, swissprot: MTR1B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(2) dopamine receptor (Organism: Bos taurus, class: GPCR, accessions: P20288, gene: DRD2, swissprot: DRD2_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(1A) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901, gene: Drd1, swissprot: DRD1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(2) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P61169, gene: Drd2, swissprot: DRD2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) D(3) dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19020, gene: Drd3, swissprot: DRD3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33533|P33535|P34975|Q9R0C9, gene: Oprd1|Oprk1|Oprm1|Sigmar1, swissprot: OPRD_RAT|OPRK_RAT|OPRM_RAT|SGMR1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: PDSP) D(3) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P35462, gene: DRD3, swissprot: DRD3_HUMAN) agonist (Source: WOMBAT-PK) D(2) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P14416, gene: DRD2, swissprot: DRD2_HUMAN) agonist (Source: WOMBAT-PK) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) agonist (Source: WOMBAT-PK) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: WOMBAT-PK) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: WOMBAT-PK) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: WOMBAT-PK) Dopamine beta-hydroxylase (Organism: Homo sapiens, class: Enzyme, accessions: P09172, gene: DBH, swissprot: DOPO_HUMAN) None (Source: WOMBAT-PK) FAD-linked sulfhydryl oxidase ALR (Organism: Homo sapiens, class: Enzyme, accessions: P55789, gene: GFER, swissprot: ALR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Lysine-specific demethylase 4E (Organism: Homo sapiens, class: Enzyme, accessions: B2RXH2, gene: KDM4E, swissprot: KDM4E_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) Adenosine A2b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276, gene: Adora2b, swissprot: AA2BR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) M18 aspartyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8I2J3, gene: None, swissprot: Q8I2J3_PLAF7) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL59) One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. cardiotonic drug (Code: CHEBI:38147) beta-adrenergic agonist (Code: CHEBI:35522) dopaminergic agent (Code: CHEBI:48560) sympathomimetic agent (Code: CHEBI:35524) Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Dopamine Agents (Code: D015259) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) 1974-02-25 FDA 2A3R
2QMZ
2VQ5
3NK2
4A7V
4DTZ
4DU2
4DUB
4XP1
5LOG
5PAH
5PHH
Click to view gentisic acid Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Arachidonate 5-lipoxygenase (Organism: Homo sapiens, class: Enzyme, accessions: P09917, gene: ALOX5, swissprot: LOX5_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1461) None MALDI matrix material (Code: CHEBI:64345) 3JUT
3NL1
3NW4
4E3D
4FAG
Click to view acipimox Hydroxycarboxylic acid receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q8TDS4, gene: HCAR2, swissprot: HCAR2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1596) lipolysis inhibitor, only to be used as additional or alternative treatment to reduce high triglyceride levels Antimetabolites (Code: D000963) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) 2014-03-13 EMA
Click to view guancidine
Click to view allomethadione None
Click to view chlorphenesin carbamate A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203) muscle relaxant (Code: CHEBI:51371) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) 1965-06-14 FDA
Click to view histidine An essential amino acid that is required for the production of HISTAMINE. 1975 FDA
Click to view bemegride A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose. Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) Respiratory System Agents (Code: D019141) None Ministry of Health of the Russian Federation
Click to view valdetamide Sedative
Click to view propylhexedrine None
Click to view pempidine A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs. Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373)
Click to view bucolome None
Click to view mechlorethamine DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL427) A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Chemical Warfare Agents (Code: D002619) Irritants (Code: D007509) Noxae (Code: D009676) Poisons (Code: D011042) 1949-03-15 FDA
Click to view orotic acid An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE. 1968-04-30 Ministry of Health of the Russian Federation
Click to view nifuroxime topical anti-infective agent used in protozoal & fungal infections; proposed as a radiosensitizing agent with solid tumors
Click to view diethadione None
Click to view ectylurea None 1956 YEAR INTRODUCED
Click to view iprazochrome used in prophylaxis of migraine Neurotransmitter Agents (Code: D018377) Serotonin Agents (Code: D018490) Serotonin Antagonists (Code: D012702)
Click to view levomenthol Transient receptor potential cation channel subfamily M member 8 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z2W7, gene: TRPM8, swissprot: TRPM8_HUMAN) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2430) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2430) Transient receptor potential cation channel subfamily A member 1 (Organism: Mus musculus, class: Unclassified, accessions: Q8BLA8, gene: Trpa1, swissprot: TRPA1_MOUSE) gating inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2430) Transient receptor potential cation channel subfamily M member 8 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q8R455, gene: Trpm8, swissprot: TRPM8_RAT) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2430) Transient receptor potential cation channel subfamily M member 8 (Organism: Mus musculus, class: Unclassified, accessions: Q8R4D5, gene: Trpm8, swissprot: TRPM8_MOUSE) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2430) An alcohol produced from mint oils or prepared synthetically, has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. antitussive (Code: CHEBI:51177) antispasmodic drug (Code: CHEBI:53784) antipruritic drug (Code: CHEBI:59683) Antipruritics (Code: D000982) Dermatologic Agents (Code: D003879) 2008 FDA
Click to view chloroxylenol 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: DRUG MATRIX) a antiseptic halogenated phenol, non-toxic, non-corrosive, non-staining with high phenol coefficient, it may be applied directly to a wound and shows no chemical reactivity toward blood molluscicide (Code: CHEBI:33904) antiseptic drug (Code: CHEBI:48218) Anthelmintics (Code: D000871) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) Antiparasitic Agents (Code: D000977) Antiplatyhelmintic Agents (Code: D000980) Disinfectants (Code: D004202) Schistosomicides (Code: D012556) None FDA
Click to view oteracil Uridine 5'-monophosphate synthase (Organism: Homo sapiens, class: Enzyme, accessions: P11172, gene: UMPS, swissprot: UMPS_HUMAN) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/8862723) Antagonist of urate oxidase. 2011-03-14 EMA
Click to view furamicid None
Click to view paramethadione Voltage-gated T-type calcium channel (Organism: Homo sapiens, class: Ion channel, accessions: O43497|O95180|Q9P0X4, gene: CACNA1G|CACNA1H|CACNA1I, swissprot: CAC1G_HUMAN|CAC1H_HUMAN|CAC1I_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1100) None 1949-06-15 FDA
Click to view nitrefazole None
Click to view ethadione None
Click to view tranexamic acid Plasminogen (Organism: Homo sapiens, class: Enzyme, accessions: P00747, gene: PLG, swissprot: PLMN_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL877) Antifibrinolytic hemostatic used in severe hemorrhage. hematologic agent (Code: CHEBI:50248) antifibrinolytic drug (Code: CHEBI:48675) Antifibrinolytic Agent (Code: N0000175634) Decreased Fibrinolysis (Code: N0000175632) Antifibrinolytic Agents (Code: D000933) Coagulants (Code: D003029) Fibrin Modulating Agents (Code: D050299) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) 1986-12-30 FDA 1CEB
Click to view oxanamide None
Click to view buformin An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation. Hypoglycemic Agents (Code: D007004) None Ministry of Health of the Russian Federation
Click to view isovaleryl diethylamide None
Click to view methylphenidate Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: PDSP) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL796) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL796) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL796) Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL796) A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE. adrenergic agent (Code: CHEBI:37962) adrenergic uptake inhibitor (Code: CHEBI:35640) dopamine uptake inhibitor (Code: CHEBI:51039) central nervous system stimulant (Code: CHEBI:35337) sympathomimetic agent (Code: CHEBI:35524) psychotropic drug (Code: CHEBI:35471) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Central Nervous System Stimulation (Code: N0000175729) 1955-12-05 FDA
Click to view oxiracetam None Central Nervous System Agents (Code: D002491) Nootropic Agents (Code: D018697) Psychotropic Drugs (Code: D011619)
Click to view tiliquinol Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1410814) None
Click to view citiolone Hepatoprotectant 1970 YEAR INTRODUCED
Click to view pregabalin Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) modulator (Source: WOMBAT-PK) Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit (Organism: Sus scrofa, class: Ion channel, accessions: O77773, gene: CACNA2D1, swissprot: O77773_PIG) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1059) Large neutral amino acids transporter small subunit 1 (Organism: Homo sapiens, class: Transporter, accessions: Q01650, gene: SLC7A5, swissprot: LAT1_HUMAN) None (Source: WOMBAT-PK) Voltage-dependent calcium channel subunit alpha-2/delta-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY47, gene: CACNA2D2, swissprot: CA2D2_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651903) Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues, pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) anticonvulsant (Code: CHEBI:35623) Analgesics (Code: D000700) Anti-Anxiety Agents (Code: D014151) Anticonvulsants (Code: D000927) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) 2004-07-06 EMA
Click to view pargyline Aldehyde dehydrogenase, mitochondrial (Organism: Rattus norvegicus, class: Enzyme, accessions: P11884, gene: Aldh2, swissprot: ALDH2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL673) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL673) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL673) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL673) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL673) A monoamine oxidase inhibitor with antihypertensive properties. Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) 1982-01-01 FDA
Click to view methylchromone None
Click to view hydralazine Ryanodine receptor 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q92736, gene: RYR2, swissprot: RYR2_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/23319593) Ryanodine receptor 2 (Organism: Rattus norvegicus, class: Ion channel, accessions: B0LPN4, gene: Ryr2, swissprot: RYR2_RAT) None (Source: http://www.ncbi.nlm.nih.gov/pubmed/23319593) Cholinesterase (Organism: Equus caballus, class: Enzyme, accessions: P81908, gene: BCHE, swissprot: CHLE_HORSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL276832) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL276832) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) DNA (cytosine-5)-methyltransferase 3B (Organism: Homo sapiens, class: Enzyme, accessions: Q9UBC3, gene: DNMT3B, swissprot: DNM3B_HUMAN) None (Source: WOMBAT-PK) DNA (cytosine-5)-methyltransferase 3A (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y6K1, gene: DNMT3A, swissprot: DNM3A_HUMAN) None (Source: WOMBAT-PK) DNA (cytosine-5)-methyltransferase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P26358, gene: DNMT1, swissprot: DNMT1_HUMAN) None (Source: WOMBAT-PK) Voltage-dependent L-type calcium channel subunit alpha-1C (Organism: Homo sapiens, class: Ion channel, accessions: Q13936, gene: CACNA1C, swissprot: CAC1C_HUMAN) None (Source: WOMBAT-PK) Aldehyde oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q06278, gene: AOX1, swissprot: AOXA_HUMAN) None (Source: WOMBAT-PK) A direct-acting vasodilator that is used as an antihypertensive agent. antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Arteriolar Vasodilation (Code: N0000175379) Arteriolar Vasodilator (Code: N0000175564) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Vasodilator Agents (Code: D014665) 1953-01-15 FDA 3LTW
Click to view tolazoline Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) antagonist (Source: WOMBAT-PK) Trace amine-associated receptor 1 (Organism: Homo sapiens, class: GPCR, accessions: Q96RJ0, gene: TAAR1, swissprot: TAAR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL770) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL770) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL770) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) antagonist (Source: WOMBAT-PK) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) antagonist (Source: WOMBAT-PK) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) antagonist (Source: WOMBAT-PK) A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. alpha-adrenergic antagonist (Code: CHEBI:37890) antihypertensive agent (Code: CHEBI:35674) vasodilator agent (Code: CHEBI:35620) Adrenergic Agents (Code: D018663) Adrenergic alpha-Antagonists (Code: D000317) Adrenergic Antagonists (Code: D018674) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Vasodilator Agents (Code: D014665) 1948-03-17 FDA
Click to view methacholine Muscarinic acetylcholine receptor M2 (Organism: Rattus norvegicus, class: GPCR, accessions: P10980, gene: Chrm2, swissprot: ACM2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL978) Muscarinic acetylcholine receptor M4 (Organism: Rattus norvegicus, class: GPCR, accessions: P08485, gene: Chrm4, swissprot: ACM4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL978) Muscarinic acetylcholine receptor M2 (Organism: Homo sapiens, class: GPCR, accessions: P08172, gene: CHRM2, swissprot: ACM2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL978) Muscarinic acetylcholine receptor M4 (Organism: Homo sapiens, class: GPCR, accessions: P08173, gene: CHRM4, swissprot: ACM4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL978) Muscarinic acetylcholine receptor M3 (Organism: Homo sapiens, class: GPCR, accessions: P20309, gene: CHRM3, swissprot: ACM3_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL978) Muscarinic acetylcholine receptor M1 (Organism: Homo sapiens, class: GPCR, accessions: P11229, gene: CHRM1, swissprot: ACM1_HUMAN) None (Source: PDSP) Muscarinic acetylcholine receptor M1 (Organism: Rattus norvegicus, class: GPCR, accessions: P08482, gene: Chrm1, swissprot: ACM1_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7438) Muscarinic acetylcholine receptor M3 (Organism: Rattus norvegicus, class: GPCR, accessions: P08483, gene: Chrm3, swissprot: ACM3_RAT) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7438) A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116) muscarinic agonist (Code: CHEBI:38325) bronchoconstrictor agent (Code: CHEBI:50141) cholinergic agonist (Code: CHEBI:38324) vasodilator agent (Code: CHEBI:35620) Cholinergic Receptor Agonist (Code: N0000175884) Autonomic Agents (Code: D001337) Bronchoconstrictor Agents (Code: D016085) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Miotics (Code: D008916) Muscarinic Agonists (Code: D018721) Neurotransmitter Agents (Code: D018377) Parasympathomimetics (Code: D010277) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) 1986-10-31 FDA
Click to view carpronium None
Click to view clomethiazole GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) None (Source: WOMBAT-PK) A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors. Anticonvulsants (Code: D000927) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neuroprotective Agents (Code: D018696) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) 1981-01-01 YEAR INTRODUCED
Click to view meglutol 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Organism: Homo sapiens, class: Enzyme, accessions: P04035, gene: HMGCR, swissprot: HMDH_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL50444) An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. anticholesteremic drug (Code: CHEBI:35821) Anticholesteremic Agents (Code: D000924) Antimetabolites (Code: D000963) Enzyme Inhibitors (Code: D004791) Hydroxymethylglutaryl-CoA Reductase Inhibitors (Code: D019161) Hypolipidemic Agents (Code: D000960) Lipid Regulating Agents (Code: D057847) 1DQ8
1DQA
Click to view fenadiazole None
Click to view aminorex An amphetamine-like anorectic agent. It may cause pulmonary hypertension.
Click to view levocarnitine Carnitine O-palmitoyltransferase 1, muscle isoform (Organism: Rattus norvegicus, class: Enzyme, accessions: Q63704, gene: Cpt1b, swissprot: CPT1B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1149) Carnitine palmitoyltransferase 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P18886, gene: Cpt2, swissprot: CPT2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1149) Carnitine O-palmitoyltransferase 1, liver isoform (Organism: Homo sapiens, class: Enzyme, accessions: P50416, gene: CPT1A, swissprot: CPT1A_HUMAN) None (Source: WOMBAT-PK) A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism. antilipemic drug (Code: CHEBI:35679) nutraceutical (Code: CHEBI:50733) nootropic agent (Code: CHEBI:66980) Carnitine (Code: N0000006688) Carnitine Analog (Code: N0000175903) 1985-12-27 FDA 3PPO
Click to view oxydibutanol None
Click to view nicotine Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) agonist (Source: WOMBAT-PK) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483, gene: Chrna4, swissprot: ACHA4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Mus musculus, class: Ion channel, accessions: O70174, gene: Chrna4, swissprot: ACHA4_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P09483|P12389|P12390|P12391|P12392|P20420|P25108|P25109|P43143|P43144|Q05941|Q9JLB5, gene: Chrna1|Chrna10|Chrna2|Chrna3|Chrna4|Chrna5|Chrna6|Chrna7|Chrna9|Chrnb1|Chrnb2|Chrnb3|Chrnb4, swissprot: ACH10_RAT|ACHA2_RAT|ACHA3_RAT|ACHA4_RAT|ACHA5_RAT|ACHA6_RAT|ACHA7_RAT|ACHA9_RAT|ACHA_RAT|ACHB2_RAT|ACHB3_RAT|ACHB4_RAT|ACHB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-9 (Organism: Rattus norvegicus, class: Ion channel, accessions: P43144, gene: Chrna9, swissprot: ACHA9_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit beta-4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12392, gene: Chrnb4, swissprot: ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389, gene: Chrna2, swissprot: ACHA2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor; alpha1/beta1/delta/gamma (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P07510|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND|CHRNG, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN|ACHG_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12390, gene: Chrna3|Chrnb2, swissprot: ACHA3_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757|P12392, gene: Chrna3|Chrnb4, swissprot: ACHA3_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12390, gene: Chrna2|Chrnb2, swissprot: ACHA2_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P12389|P12392, gene: Chrna2|Chrnb4, swissprot: ACHA2_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Nicotinic acetylcholine receptor alpha 5 subunit (Organism: Musca domestica, class: Ion channel, accessions: A9XFY4, gene: nAChRalpha5, swissprot: A9XFY4_MUSDO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor subunit delta (Organism: Torpedo californica, class: Ion channel, accessions: P02718, gene: chrnd, swissprot: ACHD_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12392, gene: Chrna4|Chrnb4, swissprot: ACHA4_RAT|ACHB4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Rattus norvegicus, class: Ion channel, accessions: P09483|P12390, gene: Chrna4|Chrnb2, swissprot: ACHA4_RAT|ACHB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Rattus norvegicus, class: Ion channel, accessions: Q05941, gene: Chrna7, swissprot: ACHA7_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Mus musculus, class: Ion channel, accessions: P49582, gene: Chrna7, swissprot: ACHA7_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor (Organism: Torpedo californica, class: Ion channel, accessions: P02710|P02712|P02714|P02718, gene: CHRNA1|CHRNB1|CHRNG|chrnd, swissprot: ACHA_TORCA|ACHB_TORCA|ACHD_TORCA|ACHG_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Rattus norvegicus, class: Ion channel, accessions: P04757, gene: Chrna3, swissprot: ACHA3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor subunit beta-like 2 (Organism: Drosophila melanogaster, class: Ion channel, accessions: P25162, gene: nAChRbeta2, swissprot: ACH4_DROME) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Muscarinic acetylcholine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P08482|P08483|P08485|P08911|P10980, gene: Chrm1|Chrm2|Chrm3|Chrm4|Chrm5, swissprot: ACM1_RAT|ACM2_RAT|ACM3_RAT|ACM4_RAT|ACM5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Serotonin 3 (5-HT3) receptor (Organism: Homo sapiens, class: Ion channel, accessions: A5X5Y0|O95264|P46098|Q70Z44|Q8WXA8, gene: HTR3A|HTR3B|HTR3C|HTR3D|HTR3E, swissprot: 5HT3A_HUMAN|5HT3B_HUMAN|5HT3C_HUMAN|5HT3D_HUMAN|5HT3E_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P02708, gene: CHRNA1, swissprot: ACHA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Lycopene cyclase (Organism: Pantoea ananas, class: Enzyme, accessions: P21687, gene: crtY, swissprot: CRTY_PANAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Soluble acetylcholine receptor (Organism: Aplysia californica, class: Unclassified, accessions: Q8WSF8, gene: None, swissprot: Q8WSF8_APLCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Gallus gallus, class: Ion channel, accessions: P09482, gene: CHRNA4, swissprot: ACHA4_CHICK) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Acetylcholine-binding protein (Organism: Lymnaea stagnalis, class: Unclassified, accessions: P58154, gene: None, swissprot: ACHP_LYMST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) None (Source: WOMBAT-PK) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297, gene: CHRNA3|CHRNB2, swissprot: ACHA3_HUMAN|ACHB2_HUMAN) None (Source: WOMBAT-PK) Cytochrome P450 2A6 (Organism: Homo sapiens, class: Enzyme, accessions: P11509, gene: CYP2A6, swissprot: CP2A6_HUMAN) None (Source: WOMBAT-PK) Potassium voltage-gated channel subfamily D member 3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9UK17, gene: KCND3, swissprot: KCND3_HUMAN) None (Source: WOMBAT-PK) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: WOMBAT-PK) Transient receptor potential cation channel subfamily A member 1 (Organism: Homo sapiens, class: Ion channel, accessions: O75762, gene: TRPA1, swissprot: TRPA1_HUMAN) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2585) Neuronal acetylcholine receptor; alpha2/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|Q15822, gene: CHRNA2|CHRNB2, swissprot: ACHA2_HUMAN|ACHB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297|Q05901|Q15825, gene: CHRNA3|CHRNA6|CHRNB2|CHRNB3, swissprot: ACHA3_HUMAN|ACHA6_HUMAN|ACHB2_HUMAN|ACHB3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL3) Potassium voltage-gated channel subfamily D member 3 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62897, gene: Kcnd3, swissprot: KCND3_RAT) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2585) Items used to aid in ending a TOBACCO habit. biomarker (Code: CHEBI:59163) immunomodulator (Code: CHEBI:50846) peripheral nervous system drug (Code: CHEBI:49110) psychotropic drug (Code: CHEBI:35471) anxiolytic drug (Code: CHEBI:35474) nicotinic acetylcholine receptor agonist (Code: CHEBI:47958) phytogenic insecticide (Code: CHEBI:22917) Cholinergic Nicotinic Agonist (Code: N0000175706) Nicotine (Code: N0000006496) Autonomic Agents (Code: D001337) Cholinergic Agents (Code: D018678) Cholinergic Agonists (Code: D018679) Ganglionic Stimulants (Code: D005731) Neurotransmitter Agents (Code: D018377) Nicotinic Agonists (Code: D018722) Peripheral Nervous System Agents (Code: D018373) 1991-11-07 FDA 1P2Y
1P7R
1UW6
2YK1
4EJG
4EJJ
5KXI
Click to view carsalam None
Click to view tiopronin Angiotensin-converting enzyme (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12822, gene: ACE, swissprot: ACE_RABIT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1314) Sulfhydryl acylated derivative of GLYCINE. Cystine Disulfide Reduction (Code: N0000175549) N-substituted Glycines (Code: N0000011378) Reducing and Complexing Thiol (Code: N0000175898) 1988-08-11 FDA 5A5Z
Click to view acetylcysteine Superoxide dismutase [Mn], mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P04179, gene: SOD2, swissprot: SODM_HUMAN) None (Source: WOMBAT-PK) Vascular endothelial growth factor A (Organism: Homo sapiens, class: Secreted, accessions: P15692, gene: VEGFA, swissprot: VEGFA_HUMAN) None (Source: WOMBAT-PK) Cytochrome c (Organism: Homo sapiens, class: Unclassified, accessions: P99999, gene: CYCS, swissprot: CYC_HUMAN) None (Source: WOMBAT-PK) The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates. antidote to paracetamol poisoning (Code: CHEBI:74529) antiinfective agent (Code: CHEBI:35441) antiviral drug (Code: CHEBI:36044) mucolytic (Code: CHEBI:77034) vulnerary (Code: CHEBI:73336) Antidote (Code: N0000175429) Antidote for Acetaminophen Overdose (Code: N0000175961) Decreased Respiratory Secretion Viscosity (Code: N0000008867) Increased Glutathione Concentration (Code: N0000175960) Reduction Activity (Code: N0000175547) Anti-Infective Agents (Code: D000890) Antioxidants (Code: D000975) Antiviral Agents (Code: D000998) Expectorants (Code: D005100) Free Radical Scavengers (Code: D016166) Respiratory System Agents (Code: D019141) 1963-09-14 FDA 5NN4
2J1G
Click to view cloforex carbamic ethyl ester of chlorphentermine; structure in Negwer, 5th ed, #2275
Click to view pentorex None
Click to view mephentermine Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200996) A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA. Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1951-12-29 FDA
Click to view etilamfetamine Sigma non-opioid intracellular receptor 1 (Organism: Homo sapiens, class: Membrane receptor, accessions: Q99720, gene: SIGMAR1, swissprot: SGMR1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL276443) None
Click to view phenylbutanoic acid glutamine (Organism: None, class: Amino acid, accessions: None, gene: None, swissprot: None) other (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020572s016,020573s015lbl.pdf) Histone deacetylase 8 (Organism: Homo sapiens, class: Enzyme, accessions: Q9BY41, gene: HDAC8, swissprot: HDAC8_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1044) Histone deacetylase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q13547, gene: HDAC1, swissprot: HDAC1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1044) Histone deacetylase 2 (Organism: Homo sapiens, class: Enzyme, accessions: Q92769, gene: HDAC2, swissprot: HDAC2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1044) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1044) a pro-drug and is rapidly metabolized to phenylacetate. Phenylacetate is a metabolically-active compound that conjugates with glutamine via acetylation to form phenylacetylglutamine. antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Antineoplastic Agents (Code: D000970) 1996-04-30 FDA 2AY7
3TZ2
3TZ5
5VNL
5VNM
5VNN
5YOQ
Click to view fenipentol stimulates plasma secretion & exocrine pancreatic secretion Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765) None Ministry of Health of the Russian Federation
Click to view methiosulfonium chloride None
Click to view methoxyflurane GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1341) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1341) An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180) inhalation anaesthetic (Code: CHEBI:38870) non-narcotic analgesic (Code: CHEBI:35481) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) None FDA
Click to view atrolactamide None
Click to view phenylalanine Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Mus musculus, class: Ion channel, accessions: O08532, gene: Cacna2d1, swissprot: CA2D1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL301523) Intestinal alkaline phosphatase (Organism: Bos taurus, class: Unclassified, accessions: P19111, gene: ALPI, swissprot: PPBI_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL301523) L-type amino acid transporter 1 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q63016, gene: Slc7a5, swissprot: LAT1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL301523) Probable G-protein coupled receptor 139 (Organism: Homo sapiens, class: Unclassified, accessions: Q6DWJ6, gene: GPR139, swissprot: GP139_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3313) An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. 1975 FDA
Click to view ethenzamide None Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antirheumatic Agents (Code: D018501) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689)
Click to view sulfaperin None antibacterial drug (Code: CHEBI:36047)
Click to view benzocaine Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 7 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q01118, gene: SCN7A, swissprot: SCN7A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 8 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UQD0, gene: SCN8A, swissprot: SCN8A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) Sodium channel protein type 11 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9UI33, gene: SCN11A, swissprot: SCNBA_HUMAN) blocker (Source: http://www.ncbi.nlm.nih.gov/pubmed/12173241) A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS. antipruritic drug (Code: CHEBI:59683) topical anaesthetic (Code: CHEBI:48425) Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) None FDA
Click to view pholedrine None Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 4LAS
Click to view pseudoephedrine Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) releasing agent (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1590) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: WOMBAT-PK) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: WOMBAT-PK) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) None (Source: WOMBAT-PK) A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion. sympathomimetic agent (Code: CHEBI:35524) anti-asthmatic drug (Code: CHEBI:49167) bronchodilator agent (Code: CHEBI:35523) vasoconstrictor agent (Code: CHEBI:50514) central nervous system drug (Code: CHEBI:35470) nasal decongestant (Code: CHEBI:77715) Adrenergic alpha-Agonists (Code: N0000000209) alpha-Adrenergic Agonist (Code: N0000175552) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Vasoconstrictor Agents (Code: D014662) 1963-10-18 FDA
Click to view ephedrine Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=556) A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. sympathomimetic agent (Code: CHEBI:35524) vasoconstrictor agent (Code: CHEBI:50514) nasal decongestant (Code: CHEBI:77715) alpha-Adrenergic Agonist (Code: N0000175552) Adrenergic alpha-Agonists (Code: N0000000209) beta-Adrenergic Agonist (Code: N0000175555) Adrenergic beta-Agonists (Code: N0000000245) Norepinephrine Releasing Agent (Code: N0000192563) Increased Norepinephrine Activity (Code: N0000009456) Adrenergic Agents (Code: D018663) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) None FDA
Click to view cycloguanil Bifunctional dihydrofolate reductase-thymidylate synthase (Organism: Plasmodium falciparum, class: Enzyme, accessions: P13922, gene: None, swissprot: DRTS_PLAFK) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) Dihydrofolate reductase (Organism: Pneumocystis carinii, class: Enzyme, accessions: P16184, gene: None, swissprot: DYR_PNECA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) Dihydrofolate reductase (Organism: Lactobacillus casei, class: Enzyme, accessions: P00381, gene: folA, swissprot: DYR_LACCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) Dihydrofolate reductase (Organism: Homo sapiens, class: Enzyme, accessions: P00374, gene: DHFR, swissprot: DYR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) Dihydrofolate reductase (Organism: Gallus gallus, class: Enzyme, accessions: P00378, gene: DHFR, swissprot: DYR_CHICK) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) Dihydrofolate reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: Q920D2, gene: Dhfr, swissprot: DYR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL747) was MH 1975-92 (see under TRIAZINES 1975-90); use CYCLOGUANIL EMBONATE was see CYCLOGUANIL PAMOATE 1975-92; TRIAZINES to search CYCLOGUANIL PAMOATE 1975-92; metabolite of chloroguanide; antimalarial Anti-Infective Agents (Code: D000890) Antimalarials (Code: D000962) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Folic Acid Antagonists (Code: D005493) 3IRM
3IRN
3UM6
3UM8
4KNE
Click to view fenoxypropazine None
Click to view edrophonium Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1104) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1104) A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. diagnostic agent (Code: CHEBI:33295) antidote (Code: CHEBI:50247) Cholinesterase Inhibitor (Code: N0000175723) Antidotes (Code: D000931) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Protective Agents (Code: D020011) 1951-05-03 FDA 1AX9
2ACK
Click to view ethionamide Catalase-peroxidase (Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh), class: Enzyme, accessions: P9WIE4, gene: katG, swissprot: KATG_MYCTO) None (Source: WOMBAT-PK) Enoyl-[acyl-carrier-protein] reductase [NADH] (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WGR1, gene: inhA, swissprot: INHA_MYCTU) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1441) A second-line antitubercular agent that inhibits mycolic acid synthesis. antitubercular agent (Code: CHEBI:33231) antilipemic drug (Code: CHEBI:35679) leprostatic drug (Code: CHEBI:35816) prodrug (Code: CHEBI:50266) Antimycobacterial (Code: N0000175483) Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antitubercular Agents (Code: D000995) Fatty Acid Synthesis Inhibitors (Code: D054872) Hypolipidemic Agents (Code: D000960) 1965-04-30 FDA
Click to view orthocaine None
Click to view aminosalicylic acid hydrazide None
Click to view thioguanine Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) inhibitor (Source: WOMBAT-PK) Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) inhibitor (Source: WOMBAT-PK) Xanthine dehydrogenase/oxidase (Organism: Homo sapiens, class: Enzyme, accessions: P47989, gene: XDH, swissprot: XDH_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL727) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) None (Source: DRUG MATRIX) Mitogen-activated protein kinase 3 (Organism: Homo sapiens, class: Kinase, accessions: P27361, gene: MAPK3, swissprot: MK03_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Hypoxanthine-guanine phosphoribosyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P00492, gene: HPRT1, swissprot: HPRT_HUMAN) None (Source: WOMBAT-PK) Multidrug resistance-associated protein 4 (Organism: Homo sapiens, class: Transporter, accessions: O15439, gene: ABCC4, swissprot: MRP4_HUMAN) None (Source: WOMBAT-PK) Multidrug resistance-associated protein 5 (Organism: Homo sapiens, class: Transporter, accessions: O15440, gene: ABCC5, swissprot: MRP5_HUMAN) None (Source: WOMBAT-PK) An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. antineoplastic agent (Code: CHEBI:35610) Antimetabolites (Code: D000963) Antimetabolites, Antineoplastic (Code: D000964) Antineoplastic Agents (Code: D000970) Noxae (Code: D009676) 1966-01-18 FDA 3JQA
3RKF
4M5M
4XOY
4XP3
5XU8
Click to view oxedrine 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL33720) Neuromedin-U receptor 2 (Organism: Homo sapiens, class: GPCR, accessions: Q9GZQ4, gene: NMUR2, swissprot: NMUR2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL33720) Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. alpha-adrenergic agonist (Code: CHEBI:35569) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662)
Click to view pyrithyldione None
Click to view phenylephrine Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: WOMBAT-PK) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: WOMBAT-PK) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) Adrenergic receptor alpha-2 (Organism: Homo sapiens, class: GPCR, accessions: P08913|P18089|P18825, gene: ADRA2A|ADRA2B|ADRA2C, swissprot: ADA2A_HUMAN|ADA2B_HUMAN|ADA2C_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: WOMBAT-PK) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1215) An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. cardiotonic drug (Code: CHEBI:38147) mydriatic agent (Code: CHEBI:50513) protective agent (Code: CHEBI:50267) vasoconstrictor agent (Code: CHEBI:50514) sympathomimetic agent (Code: CHEBI:35524) nasal decongestant (Code: CHEBI:77715) alpha-adrenergic agonist (Code: CHEBI:35569) alpha-1 Adrenergic Agonist (Code: N0000186105) Adrenergic alpha1-Agonists (Code: N0000009917) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Mydriatics (Code: D009184) Nasal Decongestants (Code: D014663) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1952-01-21 FDA
Click to view dexmethylphenidate Sodium-dependent dopamine transporter (Organism: Rattus norvegicus, class: Transporter, accessions: P23977, gene: Slc6a3, swissprot: SC6A3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL827) Dopamine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18901|P19020|P25115|P30729|P61169, gene: Drd1|Drd2|Drd3|Drd4|Drd5, swissprot: DRD1_RAT|DRD2_RAT|DRD3_RAT|DRD4_RAT|DRD5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL827) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL827) Transporter (Organism: Rattus norvegicus, class: Transporter, accessions: Q9WTR4, gene: Slc6a2, swissprot: Q9WTR4_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL827) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: WOMBAT-PK) A methylphenidate derivative, DOPAMINE UPTAKE INHIBITOR and CENTRAL NERVOUS SYSTEM STIMULANT that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. adrenergic agent (Code: CHEBI:37962) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Dopamine Agents (Code: D015259) Dopamine Uptake Inhibitors (Code: D018765) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Neurotransmitter Uptake Inhibitors (Code: D014179) Central Nervous System Stimulant (Code: N0000175739) Central Nervous System Stimulation (Code: N0000175729) 2001-11-13 FDA
Click to view metaraminol Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: WOMBAT-PK) A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION. alpha-adrenergic agonist (Code: CHEBI:35569) vasoconstrictor agent (Code: CHEBI:50514) sympathomimetic agent (Code: CHEBI:35524) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-1 Receptor Agonists (Code: D058646) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1954-09-29 FDA
Click to view ethinamate short duration hypnotic with fast onset & relatively low toxicity; may cause dependence; minor descriptor (76-85); on-line & Index Medicus search CARBAMATES (76-85) sedative (Code: CHEBI:35717) 1955-03-13 FDA
Click to view mecamylamine Neuronal acetylcholine receptor; alpha3/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P32297, gene: CHRNA3|CHRNB4, swissprot: ACHA3_HUMAN|ACHB4_HUMAN) negative allosteric modulator (Source: WOMBAT-PK) Neuronal acetylcholine receptor; alpha4/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|P43681, gene: CHRNA4|CHRNB4, swissprot: ACHA4_HUMAN|ACHB4_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3990) Neuronal acetylcholine receptor; alpha4/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P43681, gene: CHRNA4|CHRNB2, swissprot: ACHA4_HUMAN|ACHB2_HUMAN) None (Source: WOMBAT-PK) Neuronal acetylcholine receptor subunit alpha-7 (Organism: Homo sapiens, class: Ion channel, accessions: P36544, gene: CHRNA7, swissprot: ACHA7_HUMAN) None (Source: WOMBAT-PK) Neuronal acetylcholine receptor subunit alpha-6 (Organism: Homo sapiens, class: Ion channel, accessions: Q15825, gene: CHRNA6, swissprot: ACHA6_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3990) Neuronal acetylcholine receptor subunit alpha-3 (Organism: Homo sapiens, class: Ion channel, accessions: P32297, gene: CHRNA3, swissprot: ACHA3_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3990) Neuronal acetylcholine receptor subunit alpha-4 (Organism: Homo sapiens, class: Ion channel, accessions: P43681, gene: CHRNA4, swissprot: ACHA4_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3990) Acetylcholine receptor subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P02708, gene: CHRNA1, swissprot: ACHA_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3990) Neuronal acetylcholine receptor; alpha3/beta2 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297, gene: CHRNA3|CHRNB2, swissprot: ACHA3_HUMAN|ACHB2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL267936) Neuronal acetylcholine receptor; alpha2/beta4 (Organism: Homo sapiens, class: Ion channel, accessions: P30926|Q15822, gene: CHRNA2|CHRNB4, swissprot: ACHA2_HUMAN|ACHB4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL267936) Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 (Organism: Homo sapiens, class: Ion channel, accessions: P17787|P32297|Q05901|Q15825, gene: CHRNA3|CHRNA6|CHRNB2|CHRNB3, swissprot: ACHA3_HUMAN|ACHA6_HUMAN|ACHB2_HUMAN|ACHB3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL267936) Acetylcholine receptor subunit alpha (Organism: Torpedo californica, class: Ion channel, accessions: P02710, gene: CHRNA1, swissprot: ACHA_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL267936) A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. Autonomic Ganglionic Blocker (Code: N0000175641) Decreased Autonomic Ganglionic Activity (Code: N0000175644) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Cholinergic Agents (Code: D018678) Cholinergic Antagonists (Code: D018680) Ganglionic Blockers (Code: D005730) Neurotransmitter Agents (Code: D018377) Nicotinic Antagonists (Code: D018733) Peripheral Nervous System Agents (Code: D018373) 1956-03-01 FDA
Click to view desflurane Glycine receptor (alpha-1/beta) (Organism: Homo sapiens, class: Ion channel, accessions: P23415|P48167, gene: GLRA1|GLRB, swissprot: GLRA1_HUMAN|GLRB_HUMAN) positive modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1200733) volatile anesthetic that differs from isoflurane by substitution of a fluorine atom for the chlorine found on the alpha-ethyl component of isoflurane; MF: CF2-O-CFH-CF3; produces anesthetic preconditioning to protect the myocardium against infarction inhalation anaesthetic (Code: CHEBI:38870) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) 1992-09-18 FDA 3P4W
Click to view sulfametrole None
Click to view cicrotoic acid None
Click to view zoxazolamine A uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. Antirheumatic Agents (Code: D018501) Central Nervous System Agents (Code: D002491) Gout Suppressants (Code: D006074) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) Renal Agents (Code: D012076) Uricosuric Agents (Code: D014528) 4QP2
Click to view pyridoxine Phosphoserine aminotransferase (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y617, gene: PSAT1, swissprot: SERC_HUMAN) None (Source: WOMBAT-PK) Cystathionine beta-synthase (Organism: Homo sapiens, class: Enzyme, accessions: P35520, gene: CBS, swissprot: CBS_HUMAN) None (Source: WOMBAT-PK) Pyridoxal kinase (Organism: Homo sapiens, class: Kinase, accessions: O00764, gene: PDXK, swissprot: PDXK_HUMAN) None (Source: WOMBAT-PK) Pyridoxal phosphate phosphatase (Organism: Homo sapiens, class: Enzyme, accessions: Q96GD0, gene: PDXP, swissprot: PLPP_HUMAN) None (Source: WOMBAT-PK) Pyridoxine-5'-phosphate oxidase (Organism: Homo sapiens, class: Enzyme, accessions: Q9NVS9, gene: PNPO, swissprot: PNPO_HUMAN) None (Source: WOMBAT-PK) Serine hydroxymethyltransferase, cytosolic (Organism: Homo sapiens, class: Enzyme, accessions: P34896, gene: SHMT1, swissprot: GLYC_HUMAN) None (Source: WOMBAT-PK) The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamin B Complex (Code: D014803) Vitamins (Code: D014815) Vitamin B6 Analog (Code: N0000192800) Vitamin B 6 (Code: N0000005657) Analogs/Derivatives (Code: N0000175452) 1947-07-28 FDA 4C5L
4C5N
5EB3
Click to view norepinephrine Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-2 adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: Q28044, gene: ADRB2, swissprot: ADRB2_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Adrenergic receptor alpha (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P19328|P22086|P22909|P23944|P43140, gene: Adra1a|Adra1b|Adra1d|Adra2a|Adra2b|Adra2c, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT|ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-2B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P19328, gene: Adra2b, swissprot: ADA2B_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Adrenergic receptor alpha-1 (Organism: Rattus norvegicus, class: GPCR, accessions: P15823|P23944|P43140, gene: Adra1a|Adra1b|Adra1d, swissprot: ADA1A_RAT|ADA1B_RAT|ADA1D_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-2 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P10608, gene: Adrb2, swissprot: ADRB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=505) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: PDSP) Beta-3 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P13945, gene: ADRB3, swissprot: ADRB3_HUMAN) None (Source: PDSP) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: PDSP) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=505) Alpha-1A adrenergic receptor (Organism: Bos taurus, class: GPCR, accessions: P18130, gene: ADRA1A, swissprot: ADA1A_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Alpha-1B adrenergic receptor (Organism: Mesocricetus auratus, class: GPCR, accessions: P18841, gene: ADRA1B, swissprot: ADA1B_MESAU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1437) Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1950-07-13 FDA 3DYE
2QEO
3HCD
4PAH
4Y4J
5N3L
Click to view dichlorobenzyl alcohol None antiseptic drug (Code: CHEBI:48218) 1996-12-31 Health Canada
Click to view piperidione None
Click to view chlorzoxazone Calcium-activated potassium channel subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q12791, gene: KCNMA1, swissprot: KCMA1_HUMAN) opener (Source: http://www.ncbi.nlm.nih.gov/pubmed/12480161) Intermediate conductance calcium-activated potassium channel protein 4 (Organism: Homo sapiens, class: Ion channel, accessions: O15554, gene: KCNN4, swissprot: KCNN4_HUMAN) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2322) Nitric oxide synthase, brain (Organism: Rattus norvegicus, class: Enzyme, accessions: P29476, gene: Nos1, swissprot: NOS1_RAT) None (Source: DRUG MATRIX) Nitric oxide synthase, inducible (Organism: Homo sapiens, class: Enzyme, accessions: P35228, gene: NOS2, swissprot: NOS2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1371) Nitric oxide synthase, brain (Organism: Homo sapiens, class: Enzyme, accessions: P29475, gene: NOS1, swissprot: NOS1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1371) Nitric oxide synthase, endothelial (Organism: Homo sapiens, class: Enzyme, accessions: P29474, gene: NOS3, swissprot: NOS3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1371) Small conductance calcium-activated potassium channel protein 2 (Organism: Rattus norvegicus, class: Unclassified, accessions: P70604, gene: Kcnn2, swissprot: KCNN2_RAT) activator (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2322) A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) muscle relaxant (Code: CHEBI:51371) sedative (Code: CHEBI:35717) Centrally-mediated Muscle Relaxation (Code: N0000175730) Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373) 1958-08-15 FDA 1M8D
1M9J
Click to view levetiracetam Synaptic vesicle glycoprotein 2A (Organism: Homo sapiens, class: Transporter, accessions: Q7L0J3, gene: SV2A, swissprot: SV2A_HUMAN) modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1286) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: WOMBAT-PK) Voltage-dependent T-type calcium channel subunit alpha-1G (Organism: Homo sapiens, class: Ion channel, accessions: O43497, gene: CACNA1G, swissprot: CAC1G_HUMAN) None (Source: WOMBAT-PK) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) None (Source: WOMBAT-PK) Synaptic vesicle glycoprotein 2A (Organism: Rattus norvegicus, class: Unclassified, accessions: Q02563, gene: Sv2a, swissprot: SV2A_RAT) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6826) nootropic drug; facilitates memory retrieval in rats anticonvulsant (Code: CHEBI:35623) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) 1999-11-30 FDA
Click to view propylthiouracil Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: WOMBAT-PK) Type I iodothyronine deiodinase (Organism: Homo sapiens, class: Enzyme, accessions: P49895, gene: DIO1, swissprot: IOD1_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1518) Myeloperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P05164, gene: MPO, swissprot: PERM_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1518) A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) antithyroid drug (Code: CHEBI:50671) hormone antagonist (Code: CHEBI:49020) antidote to paracetamol poisoning (Code: CHEBI:74529) Antimetabolites (Code: D000963) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) Noxae (Code: D009676) Thyroid Hormone Synthesis Inhibitor (Code: N0000175918) Thyroid Hormone Synthesis Inhibitors (Code: N0000175917) 1947-07-28 FDA 4QYQ
5HPW
Click to view sobrerol None Expectorants (Code: D005100) Respiratory System Agents (Code: D019141)
Click to view metronidazole A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. Metronidazole, a nitroimidazole, exerts antibacterial effects in an anaerobic environment against most obligate anaerobes. Once metronidazole enters the organism by passive diffusion and activated in the cytoplasm of susceptible anaerobic bacteria, it is reduced; this process includes intracellular electron transport proteins such as ferredoxin, transfer of an electron to the nitro group of the metronidazole, and formation of a short-lived nitroso free radical. Because of this alteration of the metronidazole molecule, a concentration gradient is created and maintained which promotes the drug’s intracellular transport. The reduced form of metronidazole and free radicals can interact with DNA leading to inhibition of DNA synthesis and DNA degradation leading to death of the bacteria. antitrichomonal drug (Code: CHEBI:50685) prodrug (Code: CHEBI:50266) antibacterial drug (Code: CHEBI:36047) antiparasitic agent (Code: CHEBI:35442) radiosensitizing agent (Code: CHEBI:132992) Nitroimidazole Antimicrobial (Code: N0000175435) Nitroimidazoles (Code: N0000007663) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Radiation-Sensitizing Agents (Code: D011838) 1963-07-18 FDA 1W3R
Click to view gabapentin Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Homo sapiens, class: Ion channel, accessions: P54289, gene: CACNA2D1, swissprot: CA2D1_HUMAN) modulator (Source: WOMBAT-PK) Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit (Organism: Sus scrofa, class: Ion channel, accessions: O77773, gene: CACNA2D1, swissprot: O77773_PIG) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL940) Voltage-dependent calcium channel subunit alpha-2/delta-1 (Organism: Mus musculus, class: Ion channel, accessions: O08532, gene: Cacna2d1, swissprot: CA2D1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL940) Large neutral amino acids transporter small subunit 1 (Organism: Homo sapiens, class: Transporter, accessions: Q01650, gene: SLC7A5, swissprot: LAT1_HUMAN) None (Source: WOMBAT-PK) Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) None (Source: WOMBAT-PK) Gamma-aminobutyric acid type B receptor subunit 2 (Organism: Homo sapiens, class: GPCR, accessions: O75899, gene: GABBR2, swissprot: GABR2_HUMAN) None (Source: WOMBAT-PK) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) None (Source: WOMBAT-PK) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: WOMBAT-PK) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) None (Source: WOMBAT-PK) Voltage-dependent calcium channel subunit alpha-2/delta-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY47, gene: CACNA2D2, swissprot: CA2D2_HUMAN) modulator (Source: http://www.ncbi.nlm.nih.gov/pubmed/21651903) can be viewed as a cyclohexane-GABA; an oral medication for add-on therapy in the treatment of partial seizures in adult epilepsy; inhibits dopamine release from rabbit caudate nucleus anticonvulsant (Code: CHEBI:35623) Anti-epileptic Agent (Code: N0000175753) Decreased Central Nervous System Disorganized Electrical Activity (Code: N0000008486) Analgesics (Code: D000700) Anti-Anxiety Agents (Code: D014151) Anti-Dyskinesia Agents (Code: D018726) Anticonvulsants (Code: D000927) Antimanic Agents (Code: D018692) Antiparkinson Agents (Code: D000978) Calcium Channel Blockers (Code: D002121) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Membrane Transport Modulators (Code: D049990) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Psychotropic Drugs (Code: D011619) Sensory System Agents (Code: D018689) Tranquilizing Agents (Code: D014149) 1993-12-30 FDA 2A1H
2COI
2COJ
2EJ3
Click to view rasagiline Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL887) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL887) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL887) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL887) TVP-1022 is the (S)-isomer and a cardioprotective agent; monoamine oxidase type-B inhibitor that is not metabolized to amphetamine derivatives; can lead to fatal hypertensive crisis in patients who consume tyramine-rich foods neuroprotective agent (Code: CHEBI:63726) Monoamine Oxidase Inhibitor (Code: N0000175744) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) 2006-05-16 FDA 5G6S
Click to view iproheptine None
Click to view menadione Trypanothione reductase (Organism: Trypanosoma cruzi, class: Enzyme, accessions: P28593, gene: TPR, swissprot: TYTR_TRYCR) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Glutathione reductase, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P00390, gene: GSR, swissprot: GSHR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Dual specificity phosphatase Cdc25C (Organism: Homo sapiens, class: Enzyme, accessions: P30307, gene: CDC25C, swissprot: MPIP3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) M-phase inducer phosphatase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P30305, gene: CDC25B, swissprot: MPIP2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Dual specificity protein phosphatase 6 (Organism: Rattus norvegicus, class: Unclassified, accessions: Q64346, gene: Dusp6, swissprot: DUS6_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Organism: Homo sapiens, class: Enzyme, accessions: P15374, gene: UCHL3, swissprot: UCHL3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Dual specificity protein phosphatase 1 (Organism: Mus musculus, class: Unclassified, accessions: P28563, gene: Dusp1, swissprot: DUS1_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) Indoleamine 2,3-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P14902, gene: IDO1, swissprot: I23O1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL590) None nutraceutical (Code: CHEBI:50733) None FDA 1TUV
2QR2
4F8Y
Click to view sulfanilamide Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 2 (Organism: Cryptococcus neoformans var. grubii, class: Unclassified, accessions: Q3I4V7, gene: CAN2, swissprot: Q3I4V7_CRYNV) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 2 (Organism: Bos taurus, class: Enzyme, accessions: P00921, gene: CA2, swissprot: CAH2_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P07451, gene: CA3, swissprot: CAH3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 13 (Organism: Homo sapiens, class: Enzyme, accessions: Q8N1Q1, gene: CA13, swissprot: CAH13_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) Carbonic anhydrase (Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65), class: Enzyme, accessions: Q6FTL6, gene: None, swissprot: Q6FTL6_CANGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL21) None Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) 1965-06-05 FDA 1AJ0
4COQ
4F92
4F93
Click to view sodium hexacyclonate used in treatment of hyperlipoproteinemia
Click to view terpin Terpin hydrate improves mucociliary function by working directly on the bronchial secretory cells in the lower respiratory tract to liquify and facilitate the elimination of bronchial secretions. Expectorants (Code: D005100) Respiratory System Agents (Code: D019141) 2004-06-01 Ministry of Health of the Russian Federation
Click to view loprodiol None
Click to view oxaceprol None Antirheumatic Agents (Code: D018501) Dermatologic Agents (Code: D003879) 2011-03-15 CDSCO (INDIA)
Click to view acexamic acid wound-healing agent component of plasmutan
Click to view acetylleucine used for treating vestibular-related imbalance and vertigo 2017 EMA 5AFG
Click to view menadiol sulfate None
Click to view ascorbic acid Solute carrier family 23 member 1 (Organism: Homo sapiens, class: Unclassified, accessions: Q9UHI7, gene: SLC23A1, swissprot: S23A1_HUMAN) None (Source: WOMBAT-PK) Solute carrier family 23 member 2 (Organism: Homo sapiens, class: Transporter, accessions: Q9UGH3, gene: SLC23A2, swissprot: S23A2_HUMAN) None (Source: WOMBAT-PK) Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: Q02809, gene: PLOD1, swissprot: PLOD1_HUMAN) None (Source: WOMBAT-PK) Prolyl 4-hydroxylase subunit alpha-1 (Organism: Homo sapiens, class: Enzyme, accessions: P13674, gene: P4HA1, swissprot: P4HA1_HUMAN) None (Source: WOMBAT-PK) Tyrosinase (Organism: Homo sapiens, class: Enzyme, accessions: P14679, gene: TYR, swissprot: TYRO_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL196) Pancreatic alpha-amylase (Organism: Rattus norvegicus, class: Unclassified, accessions: P00689, gene: Amy2, swissprot: AMYP_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL196) A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. vitamin C (Code: CHEBI:21241) flour treatment agent (Code: CHEBI:64577) food antioxidant (Code: CHEBI:77962) Ascorbic Acid (Code: N0000006439) Antioxidants (Code: D000975) Growth Substances (Code: D006133) Micronutrients (Code: D018977) Protective Agents (Code: D020011) Vitamins (Code: D014815) 1947-07-28 FDA 1E71
1E72
1E73
1F9G
1OAF
1XID
2X08
2YLD
2YLG
3EKA
3FXR
3TGY
3VLN
3VXI
3ZWI
4CIP
4GPC
4GPH
4JTP
4O79
4O7G
4RP8
4RP9
4TVT
4TWL
5D9W
5JCN
5JLI
5JRA
5JS5
5JSL
5JT4
5KKZ
Click to view arginine hydrochloride Nitric oxide synthase, inducible (Organism: Homo sapiens, class: Enzyme, accessions: P35228, gene: NOS2, swissprot: NOS2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1485) An essential amino acid that is physiologically active in the L-form. 1973-02-28 FDA
Click to view carfimate None
Click to view citrulline None None FDA 4MD5
4MD0
4MD4
1H70
1J1Z
1J21
1K97
1KP3
1LXY
1OL1
1QR3
2C6Z
2JAI
2NZ2
2W65
3B3I
3B6S
3DTX
3FT2
3HCV
3OE0
3ZOP
3ZP4
3ZP7
4GVY
4JQO
4MCY
4MCZ
4MDI
5IV2
5IVZ
5JLZ
5MU0
5MUB
5MV4
5UHR
6ATI
6ATZ
6BIJ
6BIL
6BIN
6BIR
6BIV
6BIX
6BIZ
6EQV
Click to view benzalamide None
Click to view tidiacic None 5FF2
Click to view glucurolactone None
Click to view hymecromone Aldose reductase (Organism: Rattus norvegicus, class: Enzyme, accessions: P07943, gene: Akr1b1, swissprot: ALDR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) Testosterone 17-beta-dehydrogenase 3 (Organism: Homo sapiens, class: Enzyme, accessions: P37058, gene: HSD17B3, swissprot: DHB3_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) Aldose reductase (Organism: Homo sapiens, class: Enzyme, accessions: P15121, gene: AKR1B1, swissprot: ALDR_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12208) A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID. antineoplastic agent (Code: CHEBI:35610) Indicators and Reagents (Code: D007202) 2008-07-31 Ministry of Health of the Russian Federation 3ETS
4AX7
4V28
5IK5
5IK8
5JR3
Click to view pemoline Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: DRUG MATRIX) A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children. central nervous system stimulant (Code: CHEBI:35337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) 1975-01-27 FDA
Click to view cotinine Neuronal acetylcholine receptor subunit alpha-2 (Organism: Homo sapiens, class: Ion channel, accessions: Q15822, gene: CHRNA2, swissprot: ACHA2_HUMAN) None (Source: WOMBAT-PK) The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties. biomarker (Code: CHEBI:59163) antidepressant (Code: CHEBI:35469) Indicators and Reagents (Code: D007202)
Click to view meptazinol Acetylcholinesterase (Organism: Mus musculus, class: Enzyme, accessions: P21836, gene: Ache, swissprot: ACES_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314437) Cholinesterase (Organism: Mus musculus, class: Enzyme, accessions: Q03311, gene: Bche, swissprot: CHLE_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL314437) Mu-type opioid receptor (Organism: Homo sapiens, class: GPCR, accessions: P35372, gene: OPRM1, swissprot: OPRM_HUMAN) partial agonist (Source: WOMBAT-PK) A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain. Analgesics (Code: D000700) Analgesics, Opioid (Code: D000701) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Narcotic Antagonists (Code: D009292) Narcotics (Code: D009294) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1983-01-01 YEAR INTRODUCED
Click to view metamfepramone None
Click to view phenmetrazine Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: WOMBAT-PK) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: WOMBAT-PK) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: WOMBAT-PK) A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE. Anti-Obesity Agents (Code: D019440) Appetite Depressants (Code: D001067) Autonomic Agents (Code: D001337) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 1982-01-01 FDA
Click to view betanidine Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) substrate (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1201260) A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. antihypertensive agent (Code: CHEBI:35674) adrenergic antagonist (Code: CHEBI:37887) Adrenergic Agents (Code: D018663) Antihypertensive Agents (Code: D000959) Autonomic Agents (Code: D001337) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Sympatholytics (Code: D013565) 1982-01-01 FDA
Click to view rimantadine Matrix protein 2 (Organism: Influenza A virus (strain A/Ann Arbor/6/1960 H2N2), class: Ion channel, accessions: P21430, gene: M, swissprot: M2_I60A0) None (Source: WOMBAT-PK) Multidrug and toxin extrusion protein 1 (Organism: Homo sapiens, class: Transporter, accessions: Q96FL8, gene: SLC47A1, swissprot: S47A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL959) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL959) Matrix protein 2 (Organism: Influenza A virus (strain A/Udorn/307/1972 H3N2), class: Ion channel, accessions: P63231, gene: M, swissprot: M2_I72A2) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL959) An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. Influenza A M2 Protein Inhibitor (Code: N0000175543) M2 Protein Inhibitors (Code: N0000175542) Anti-Infective Agents (Code: D000890) Antiviral Agents (Code: D000998) Enzyme Inhibitors (Code: D004791) Nucleic Acid Synthesis Inhibitors (Code: D019384) 1993-09-17 FDA 2LJC
2RLF
Click to view lidocaine Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2623) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Sodium channel alpha subunits; brain (Types I, II, III) (Organism: Rattus norvegicus, class: Ion channel, accessions: P04774|P04775|P08104, gene: Scn1a|Scn2a|Scn3a, swissprot: SCN1A_RAT|SCN2A_RAT|SCN3A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Sodium channel protein type 3 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY46, gene: SCN3A, swissprot: SCN3A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL79) Acetylcholine receptor (Organism: Homo sapiens, class: Ion channel, accessions: P02708|P11230|Q07001, gene: CHRNA1|CHRNB1|CHRND, swissprot: ACHA_HUMAN|ACHB_HUMAN|ACHD_HUMAN) None (Source: WOMBAT-PK) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) None (Source: WOMBAT-PK) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: WOMBAT-PK) Sodium channel protein type 5 subunit alpha (Organism: Rattus norvegicus, class: Unclassified, accessions: P15389, gene: Scn5a, swissprot: SCN5A_RAT) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2623) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2623) A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE. Amide Local Anesthetic (Code: N0000175682) Amides (Code: N0000007681) Antiarrhythmic (Code: N0000175426) Local Anesthesia (Code: N0000175976) Anesthetics (Code: D000777) Anesthetics, Local (Code: D000779) Anti-Arrhythmia Agents (Code: D000889) drug allergen (Code: CHEBI:88188) local anaesthetic (Code: CHEBI:36333) anti-arrhythmia drug (Code: CHEBI:38070) Cardiovascular Agents (Code: D002317) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Membrane Transport Modulators (Code: D049990) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) 1948-11-19 FDA 3JQZ
3TTR
Click to view chlorobutanol A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics. Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) 2006 Ministry of Health of the Russian Federation
Click to view phenacemide Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) blocker (Source: WOMBAT-PK) anti-epileptic drug; structure 1951-06-28 FDA
Click to view nikethamide A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292) 1967-07-11 Ministry of Health of the Russian Federation
Click to view propofol Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: DRUG MATRIX) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: DRUG MATRIX) 5-hydroxytryptamine receptor 2C (Organism: Homo sapiens, class: GPCR, accessions: P28335, gene: HTR2C, swissprot: 5HT2C_HUMAN) None (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Fatty-acid amide hydrolase 1 (Organism: Rattus norvegicus, class: Enzyme, accessions: P97612, gene: Faah, swissprot: FAAH1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL526) GABA-A receptor alpha-1/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P47870, gene: GABRA1|GABRB2|GABRG2, swissprot: GBRA1_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL526) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL526) GABA-A receptor; anion channel (Organism: Rattus norvegicus, class: Ion channel, accessions: O09028|P15431|P18506|P18508|P19969|P20236|P23574|P23576|P28471|P28473|P30191|P62813|P63079|P63138|Q91ZM7|Q9ES14, gene: Gabra1|Gabra2|Gabra3|Gabra4|Gabra5|Gabra6|Gabrb1|Gabrb2|Gabrb3|Gabrd|Gabre|Gabrg1|Gabrg2|Gabrg3|Gabrp|Gabrq, swissprot: GBRA1_RAT|GBRA2_RAT|GBRA3_RAT|GBRA4_RAT|GBRA5_RAT|GBRA6_RAT|GBRB1_RAT|GBRB2_RAT|GBRB3_RAT|GBRD_RAT|GBRE_RAT|GBRG1_RAT|GBRG2_RAT|GBRG3_RAT|GBRP_RAT|Q91ZM7_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL526) GABA A receptor alpha-2/beta-2/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P18507|P47869|P47870, gene: GABRA2|GABRB2|GABRG2, swissprot: GBRA2_HUMAN|GBRB2_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL526) Cytochrome P450 2C9 (Organism: Homo sapiens, class: Enzyme, accessions: P11712, gene: CYP2C9, swissprot: CP2C9_HUMAN) None (Source: WOMBAT-PK) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: WOMBAT-PK) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: WOMBAT-PK) Fatty-acid amide hydrolase 1 (Organism: Homo sapiens, class: Enzyme, accessions: O00519, gene: FAAH, swissprot: FAAH1_HUMAN) None (Source: WOMBAT-PK) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Organism: Mus musculus, class: Ion channel, accessions: O88704, gene: Hcn1, swissprot: HCN1_MOUSE) blocker (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5464) An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS. intravenous anaesthetic (Code: CHEBI:38877) sedative (Code: CHEBI:35717) antiemetic (Code: CHEBI:50919) anticonvulsant (Code: CHEBI:35623) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Intravenous (Code: D018686) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) Hypnotics and Sedatives (Code: D006993) 1989-10-02 FDA 1E7A
3F33
3P50
5MUO
5MUR
5MVM
5MVN
5MZR
Click to view fluostigmine Lysosomal protective protein (Organism: Homo sapiens, class: Enzyme, accessions: P10619, gene: CTSA, swissprot: PPGB_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1025) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1025) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1025) Acetylcholinesterase (Organism: Electrophorus electricus, class: Enzyme, accessions: O42275, gene: ache, swissprot: ACES_ELEEL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1025) Liver carboxylesterase (Organism: Sus scrofa, class: Enzyme, accessions: Q29550, gene: None, swissprot: EST1_PIG) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1025) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) None (Source: PDSP) A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM. Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Protease Inhibitors (Code: D011480) 1957-04-02 FDA
Click to view glucosamine None None FDA 1E9L
1FI1
1QFF
1QFG
1QGI
1QKC
2VZS
2VZV
2XAD
3CO4
3FXI
3V0W
3VFJ
3VFK
3WQV
3WQW
4CU4
4MFL
4MFP
4MFQ
4OLT
4P7N
4PJZ
4PK0
4Q36
4QWP
4Y9T
4ZZ8
5DGR
5GQB
5GSM
5HWA
5KF8
5KGP
5NNW
5UW4
5W7B
5W7F
Click to view salacetamide a derivative of salicylic acid. It is analgesic, anti-inflammatory and antipyretic agent.
Click to view phenprobamate Muscle relaxant & tranquiliser 1964 CDSCO (INDIA)
Click to view phenacetin Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) None (Source: WOMBAT-PK) A phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market. (From Smith and Reynard, Textbook of Pharmacology,1991, p431) non-narcotic analgesic (Code: CHEBI:35481) peripheral nervous system drug (Code: CHEBI:49110) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Central Nervous System Agents (Code: D002491) Peripheral Nervous System Agents (Code: D018373) Sensory System Agents (Code: D018689) 1887-01-01 YEAR INTRODUCED 3EBS
Click to view homarylamine None
Click to view glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) 1946-01-17 FDA 5YSD
Click to view iproniazid Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL92401) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL92401) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL92401) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL92401) An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity. Antidepressive Agents (Code: D000928) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Psychotropic Drugs (Code: D011619)
Click to view fudosteine fudosteine is the (R)-isomer 2013-08-29 China Food and Drug Administration (CFDA)
Click to view methylephedrine None 2013 China Food and Drug Administration (CFDA)
Click to view protionamide Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents. Anti-Bacterial Agents (Code: D000900) Anti-Infective Agents (Code: D000890) Antitubercular Agents (Code: D000995) 2005-07-09 Ministry of Health of the Russian Federation
Click to view mexiletine Sodium channel protein type 4 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35499, gene: SCN4A, swissprot: SCN4A_HUMAN) blocker (Source: WOMBAT-PK) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: DRUG MATRIX) Sodium channel protein type 10 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y5Y9, gene: SCN10A, swissprot: SCNAA_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Sodium channel protein type 9 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q15858, gene: SCN9A, swissprot: SCN9A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Potassium voltage-gated channel subfamily H member 2 (Organism: Homo sapiens, class: Ion channel, accessions: Q12809, gene: KCNH2, swissprot: KCNH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Sodium channel protein type X alpha subunit (Organism: Rattus norvegicus, class: Unclassified, accessions: Q62968, gene: Scn10a, swissprot: SCNAA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Sodium channel protein type 2 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q99250, gene: SCN2A, swissprot: SCN2A_HUMAN) blocker (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Sodium channel protein type 5 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: Q14524, gene: SCN5A, swissprot: SCN5A_HUMAN) blocker (Source: WOMBAT-PK) Solute carrier family 22 member 2 (Organism: Homo sapiens, class: Transporter, accessions: O15244, gene: SLC22A2, swissprot: S22A2_HUMAN) None (Source: WOMBAT-PK) Sodium channel subunit beta-4 (Organism: Homo sapiens, class: Ion channel, accessions: Q8IWT1, gene: SCN4B, swissprot: SCN4B_HUMAN) None (Source: WOMBAT-PK) Sodium channel subunit beta-3 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NY72, gene: SCN3B, swissprot: SCN3B_HUMAN) None (Source: WOMBAT-PK) Sodium channel subunit beta-2 (Organism: Homo sapiens, class: Ion channel, accessions: O60939, gene: SCN2B, swissprot: SCN2B_HUMAN) None (Source: WOMBAT-PK) Sodium channel subunit beta-1 (Organism: Homo sapiens, class: Ion channel, accessions: Q07699, gene: SCN1B, swissprot: SCN1B_HUMAN) None (Source: WOMBAT-PK) Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Organism: Homo sapiens, class: Ion channel, accessions: Q9Y3Q4, gene: HCN4, swissprot: HCN4_HUMAN) None (Source: WOMBAT-PK) Sodium channel protein type 1 subunit alpha (Organism: Homo sapiens, class: Ion channel, accessions: P35498, gene: SCN1A, swissprot: SCN1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Sodium channel protein type 9 subunit alpha (Organism: Mus musculus, class: Unclassified, accessions: Q62205, gene: Scn9a, swissprot: SCN9A_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL558) Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties. anti-arrhythmia drug (Code: CHEBI:38070) Antiarrhythmic (Code: N0000175426) Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Membrane Transport Modulators (Code: D049990) Sodium Channel Blockers (Code: D026941) Voltage-Gated Sodium Channel Blockers (Code: D061567) 1985-12-30 FDA 2VIN
Click to view methoxyphenamine None Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic beta-Agonists (Code: D000318) Neurotransmitter Agents (Code: D018377) 1969-12-31 New Zealand Medicines and Medical Devices Safety Authority
Click to view memantine Glutamate receptor ionotropic, NMDA 3A (Organism: Homo sapiens, class: Ion channel, accessions: Q8TCU5, gene: GRIN3A, swissprot: NMD3A_HUMAN) negative allosteric modulator (Source: WOMBAT-PK) Solute carrier family 22 member 1 (Organism: Homo sapiens, class: Transporter, accessions: O15245, gene: SLC22A1, swissprot: S22A1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL807) Glutamate receptor ionotropic, NMDA 2C (Organism: Rattus norvegicus, class: Ion channel, accessions: Q00961, gene: Grin2c, swissprot: NMDE3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL807) Glutamate NMDA receptor; GRIN1/GRIN2B (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q13224, gene: GRIN1|GRIN2B, swissprot: NMDE2_HUMAN|NMDZ1_HUMAN) negative allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL807) Glutamate NMDA receptor; GRIN1/GRIN2A (Organism: Homo sapiens, class: Ion channel, accessions: Q05586|Q12879, gene: GRIN1|GRIN2A, swissprot: NMDE1_HUMAN|NMDZ1_HUMAN) negative allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL807) Glutamate receptor ionotropic, NMDA 1 (Organism: Homo sapiens, class: Ion channel, accessions: Q05586, gene: GRIN1, swissprot: NMDZ1_HUMAN) negative allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL807) 5-hydroxytryptamine receptor 3A (Organism: Homo sapiens, class: Ion channel, accessions: P46098, gene: HTR3A, swissprot: 5HT3A_HUMAN) None (Source: WOMBAT-PK) AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent. dopaminergic agent (Code: CHEBI:48560) antiparkinson drug (Code: CHEBI:48407) neuroprotective agent (Code: CHEBI:63726) antidepressant (Code: CHEBI:35469) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Dopamine Agents (Code: D015259) Excitatory Amino Acid Agents (Code: D018683) Excitatory Amino Acid Antagonists (Code: D018691) Neurotransmitter Agents (Code: D018377) NMDA Receptor Antagonists (Code: N0000020015) N-methyl-D-aspartate Receptor Antagonist (Code: N0000175745) 2003-10-16 FDA 4TWD
Click to view cloxiquine Methionine aminopeptidase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P50579, gene: METAP2, swissprot: MAP2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225164) Methionine aminopeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P53582, gene: METAP1, swissprot: MAP11_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225164) Catechol O-methyltransferase (Organism: Rattus norvegicus, class: Enzyme, accessions: P22734, gene: Comt, swissprot: COMT_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL225164) has antitubercular activity
Click to view flurotyl A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy. Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) Convulsants (Code: D003292)
Click to view inositol An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. Growth Substances (Code: D006133) Micronutrients (Code: D018977) Vitamins (Code: D014815) Vitamin B Complex (Code: D014803) None FDA 1AOD
1G0I
1IEV
1PTG
1Y7V
2HUO
2OS9
2R71
2X1I
3BXD
3EA2
3NT4
3NTR
3V16
3V1H
4F2B
4I9T
4IRX
4MIO
4MIY
4RU1
4RV3
4RXM
4S3G
4WRE
4WUW
4XF6
4XF7
4YO7
5FYR
Click to view galactose An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Click to view fructose A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding. Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Sweetening Agents (Code: D013549) None FDA 5XHA
5F11
5GOO
3VSS
Click to view acetylsalicylic acid Gamma-glutamyltranspeptidase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P19440, gene: GGT1, swissprot: GGT1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25) Prostaglandin G/H synthase 1 (Organism: Bos taurus, class: Enzyme, accessions: O62664, gene: PTGS1, swissprot: PGH1_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25) Prostaglandin G/H synthase 2 (Organism: Ovis aries, class: Enzyme, accessions: P79208, gene: PTGS2, swissprot: PGH2_SHEEP) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25) Prostaglandin G/H synthase 1 (Organism: Ovis aries, class: Enzyme, accessions: P05979, gene: PTGS1, swissprot: PGH1_SHEEP) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25) Prostaglandin G/H synthase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P23219, gene: PTGS1, swissprot: PGH1_HUMAN) inhibitor (Source: WOMBAT-PK) Prostaglandin G/H synthase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P35354, gene: PTGS2, swissprot: PGH2_HUMAN) inhibitor (Source: WOMBAT-PK) Acidic phospholipase A2 3 (Organism: Naja sagittifera, class: Enzyme, accessions: P60045, gene: None, swissprot: PA2A3_NAJSG) None (Source: WOMBAT-PK) The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) plant activator (Code: CHEBI:73182) drug allergen (Code: CHEBI:88188) platelet aggregation inhibitor (Code: CHEBI:50427) antipyretic (Code: CHEBI:35493) prostaglandin antagonist (Code: CHEBI:49023) anticoagulant (Code: CHEBI:50249) non-steroidal anti-inflammatory drug (Code: CHEBI:35475) non-narcotic analgesic (Code: CHEBI:35481) Decreased Prostaglandin Production (Code: N0000008836) Nonsteroidal Anti-inflammatory Compounds (Code: N0000175721) Nonsteroidal Anti-inflammatory Drug (Code: N0000175722) Decreased Platelet Aggregation (Code: N0000008832) Analgesics (Code: D000700) Analgesics, Non-Narcotic (Code: D018712) Anti-Inflammatory Agents (Code: D000893) Anti-Inflammatory Agents, Non-Steroidal (Code: D000894) Antipyretics (Code: D058633) Antirheumatic Agents (Code: D018501) Cardiovascular Agents (Code: D002317) Cyclooxygenase Inhibitors (Code: D016861) Enzyme Inhibitors (Code: D004791) Fibrin Modulating Agents (Code: D050299) Fibrinolytic Agents (Code: D005343) Hematologic Agents (Code: D006401) Peripheral Nervous System Agents (Code: D018373) Platelet Aggregation Inhibitors (Code: D010975) Sensory System Agents (Code: D018689) 1950-04-12 FDA 1898-01-01 YEAR INTRODUCED 1OXR
1TGM
2QQT
3GCL
3IAZ
4NSB
Click to view clorindione Arachidonate 5-lipoxygenase (Organism: Rattus norvegicus, class: Enzyme, accessions: P12527, gene: Alox5, swissprot: LOX5_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL278519) None
Click to view theophylline cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Organism: Homo sapiens, class: Enzyme, accessions: P27815, gene: PDE4A, swissprot: PDE4A_HUMAN) inhibitor (Source: WOMBAT-PK) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) inhibitor (Source: WOMBAT-PK) Adenosine receptor A2b (Organism: Homo sapiens, class: GPCR, accessions: P29275, gene: ADORA2B, swissprot: AA2BR_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Organism: Homo sapiens, class: Kinase, accessions: O00329, gene: PIK3CD, swissprot: PK3CD_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A1 (Organism: Bos taurus, class: GPCR, accessions: P28190, gene: ADORA1, swissprot: AA1R_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A3 (Organism: Homo sapiens, class: GPCR, accessions: P0DMS8, gene: ADORA3, swissprot: AA3R_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A1 (Organism: Rattus norvegicus, class: GPCR, accessions: P25099, gene: Adora1, swissprot: AA1R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine A2a receptor (Organism: Cavia porcellus, class: Unclassified, accessions: P46616, gene: ADORA2A, swissprot: AA2AR_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A2a (Organism: Rattus norvegicus, class: GPCR, accessions: P30543, gene: Adora2a, swissprot: AA2AR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine A2 receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276|P30543, gene: Adora2a|Adora2b, swissprot: AA2AR_RAT|AA2BR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Heart phosphodiesterase (Organism: Bos taurus, class: Enzyme, accessions: E1BN64|P14100|Q01061, gene: PDE1A|PDE1B|PDE3B, swissprot: E1BN64_BOVIN|PDE1A_BOVIN|PDE1B_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A3 (Organism: Rattus norvegicus, class: GPCR, accessions: P28647, gene: Adora3, swissprot: AA3R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Uncharacterized protein (Organism: Bos taurus, class: Enzyme, accessions: E1BN64, gene: PDE3B, swissprot: E1BN64_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine A2b receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P29276, gene: Adora2b, swissprot: AA2BR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A2a (Organism: Homo sapiens, class: GPCR, accessions: P29274, gene: ADORA2A, swissprot: AA2AR_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A1 (Organism: Homo sapiens, class: GPCR, accessions: P30542, gene: ADORA1, swissprot: AA1R_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Alkaline phosphatase, tissue-nonspecific isozyme (Organism: Homo sapiens, class: Enzyme, accessions: P05186, gene: ALPL, swissprot: PPBT_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A1 (Organism: Cavia porcellus, class: GPCR, accessions: P47745, gene: ADORA1, swissprot: AA1R_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P25099|P28647|P29276|P30543, gene: Adora1|Adora2a|Adora2b|Adora3, swissprot: AA1R_RAT|AA2AR_RAT|AA2BR_RAT|AA3R_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL190) Adenosine receptor A2b (Organism: Mus musculus, class: Unclassified, accessions: Q60614, gene: Adora2b, swissprot: AA2BR_MOUSE) antagonist (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=413) A plant genus of the family ASTERACEAE. The name "prickly burweed" is sometimes used but causes confusion with AMSINCKIA. muscle relaxant (Code: CHEBI:51371) bronchodilator agent (Code: CHEBI:35523) vasodilator agent (Code: CHEBI:35620) immunomodulator (Code: CHEBI:50846) anti-inflammatory agent (Code: CHEBI:67079) anti-asthmatic drug (Code: CHEBI:49167) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Purinergic Agents (Code: D058905) Purinergic Antagonists (Code: D058914) Purinergic P1 Receptor Antagonists (Code: D058915) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) Methylxanthine (Code: N0000175790) Xanthines (Code: N0000008118) 1947-10-17 FDA 2A3A
3ROX
4EOH
5MZJ
1O15
1EHT
Click to view theobromine 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9) vasodilator agent (Code: CHEBI:35620) bronchodilator agent (Code: CHEBI:35523) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Vasodilator Agents (Code: D014665) 2EFJ
Click to view propylparaben None Standardized Chemical Allergen (Code: N0000185508) Increased Histamine Release (Code: N0000175629) Cell-mediated Immunity (Code: N0000184306) Allergens (Code: N0000171131) Pharmaceutic Aids (Code: D010592) Preservatives, Pharmaceutical (Code: D011310) 4TV1
Click to view mephenesin A centrally acting muscle relaxant with a short duration of action. Central Nervous System Agents (Code: D002491) Muscle Relaxants, Central (Code: D009125) Neuromuscular Agents (Code: D009465) Peripheral Nervous System Agents (Code: D018373)
Click to view rilmenidine Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Nischarin (Organism: Rattus norvegicus, class: Unclassified, accessions: Q4G017, gene: Nisch, swissprot: NISCH_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Nischarin (Organism: Homo sapiens, class: Cytosolic other, accessions: Q9Y2I1, gene: NISCH, swissprot: NISCH_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL289480) Rilmenidine is a centrally-acting antihypertensive. It acts through stimulation of central imidazoline receptors and has ?2-adrenoceptor agonist activity. Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Antihypertensive Agents (Code: D000959) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) 2004-12-20 Ministry of Health of the Russian Federation
Click to view tyrosine A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. 1975 FDA 6BQZ
5M8P
Click to view styramate Styramate is a centrally acting skeletal muscle relaxant that was used in the symptomatic treatment of painful muscle spasm associated with musculoskeletal conditions.
Click to view adrenalone None Cardiovascular Agents (Code: D002317) Coagulants (Code: D003029) Hematologic Agents (Code: D006401) Hemostatics (Code: D006490) Vasoconstrictor Agents (Code: D014662)
Click to view acamprosate Glutamate [NMDA] receptor (Organism: Homo sapiens, class: Ion channel, accessions: O15399|O60391|Q05586|Q12879|Q13224|Q14957|Q8TCU5, gene: GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B, swissprot: NMD3A_HUMAN|NMD3B_HUMAN|NMDE1_HUMAN|NMDE2_HUMAN|NMDE3_HUMAN|NMDE4_HUMAN|NMDZ1_HUMAN) antagonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1201293) GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive modulator (Source: WOMBAT-PK) The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. In vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. neurotransmitter agent (Code: CHEBI:35942) Alcohol Deterrents (Code: D000427) Central Nervous System Agents (Code: D002491) 2004-07-29 FDA
Click to view pyridostigmine Acetylcholinesterase (Organism: Bos taurus, class: Enzyme, accessions: P23795, gene: ACHE, swissprot: ACES_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL812) Acetylcholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P22303, gene: ACHE, swissprot: ACES_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL812) Acetylcholinesterase (Organism: Torpedo californica, class: Enzyme, accessions: P04058, gene: ache, swissprot: ACES_TORCA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL812) Cholinesterase (Organism: Homo sapiens, class: Enzyme, accessions: P06276, gene: BCHE, swissprot: CHLE_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL812) A cholinesterase inhibitor with a slightly longer duration of action than NEOSTIGMINE. It is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Cholinesterase Inhibitor (Code: N0000175723) Cholinergic Agents (Code: D018678) Cholinesterase Inhibitors (Code: D002800) Enzyme Inhibitors (Code: D004791) Neurotransmitter Agents (Code: D018377) 1955-04-06 FDA
Click to view oxilofrine None
Click to view hexapropymate None
Click to view etilefrine Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) agonist (Source: http://www.ncbi.nlm.nih.gov/pubmed/4396765) A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent. Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Adrenergic beta-1 Receptor Agonists (Code: D058665) Adrenergic beta-Agonists (Code: D000318) Autonomic Agents (Code: D001337) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Protective Agents (Code: D020011) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1929-01-01 YEAR INTRODUCED
Click to view eflornithine Ornithine decarboxylase (Organism: Trypanosoma brucei gambiense, class: Enzyme, accessions: Q9TZZ6, gene: None, swissprot: Q9TZZ6_TRYBG) inhibitor (Source: http://www.ncbi.nlm.nih.gov/pubmed/3924048) Ornithine decarboxylase (Organism: Rattus norvegicus, class: Unclassified, accessions: P09057, gene: Odc1, swissprot: DCOR_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL830) Ornithine decarboxylase (Organism: Homo sapiens, class: Enzyme, accessions: P11926, gene: ODC1, swissprot: DCOR_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5176) An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway. Antiprotozoal (Code: N0000175485) Decarboxylase Inhibitor (Code: N0000175845) Decarboxylase Inhibitors (Code: N0000175844) Anti-Infective Agents (Code: D000890) Antineoplastic Agents (Code: D000970) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) Enzyme Inhibitors (Code: D004791) Ornithine Decarboxylase Inhibitors (Code: D065108) Trypanocidal Agents (Code: D014344) 1990-11-28 FDA 2TOD
3GN0
Click to view sorbitol A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications. Cathartics (Code: D002400) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Gastrointestinal Agents (Code: D005765) Indicators and Reagents (Code: D007202) Sweetening Agents (Code: D013549) 1971-08-20 FDA 1D8C
1FQA
1FQB
1XIH
2DXR
2VFT
2XIN
3BRF
3XIM
4DVO
4XIA
5A06
5JO9
5K4P
5M6G
5NHA
5XIM
6BJD
Click to view mannitol A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity. Increased Diuresis (Code: N0000175359) Osmotic Activity (Code: N0000010288) Osmotic Diuretic (Code: N0000175810) Diuretics (Code: D004232) Diuretics, Osmotic (Code: D004234) Flavoring Agents (Code: D005421) Food Additives (Code: D005503) Natriuretic Agents (Code: D045283) Sweetening Agents (Code: D013549) 1964-06-08 FDA 1M2W
1P6K
1RS6
1RS7
1ZZQ
1ZZU
2VFU
3N62
3N65
3N66
4D33
4D39
4KCN
4RYA
5VUN
5VUO
Click to view glycol salicylate component of Piadar; topical ointment of the above including 1% methanol in base None FDA
Click to view sparteine A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype. Anti-Arrhythmia Agents (Code: D000889) Cardiovascular Agents (Code: D002317) Oxytocics (Code: D010120) Reproductive Control Agents (Code: D012102)
Click to view flopropione Catechol O-methyltransferase (Organism: Homo sapiens, class: Enzyme, accessions: P21964, gene: COMT, swissprot: COMT_HUMAN) inhibitor (Source: http://eisai.jp/medical/products/di/EPI/CSP_C_EPI.pdf) The mechanism of action is considered to be based on the inhibition of catechol-o-methyl-transferase (COMT), resulting in an adrenergic action, and anti-serotonin action
Click to view dacarbazine Matrix metalloproteinase-9 (Organism: Homo sapiens, class: Enzyme, accessions: P14780, gene: MMP9, swissprot: MMP9_HUMAN) None (Source: DRUG MATRIX) DNA polymerase alpha subunit B (Organism: Homo sapiens, class: Unclassified, accessions: Q14181, gene: POLA2, swissprot: DPOA2_HUMAN) None (Source: WOMBAT-PK) DNA (Organism: None, class: DNA, accessions: None, gene: None, swissprot: None) other (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL476) An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564) antineoplastic agent (Code: CHEBI:35610) prodrug (Code: CHEBI:50266) Alkylating Activity (Code: N0000000236) Alkylating Drug (Code: N0000175558) Alkylating Agents (Code: D000477) Antineoplastic Agents (Code: D000970) Antineoplastic Agents, Alkylating (Code: D018906) Noxae (Code: D009676) 1975-05-27 FDA
Click to view succimer lead (Organism: None, class: Inorganic material, accessions: None, gene: None, swissprot: None) chelating agent (Source: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/019998s013lbl.pdf) A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. Lead Chelating Activity (Code: N0000175962) Lead Chelator (Code: N0000175963) Antidotes (Code: D000931) Chelating Agents (Code: D002614) Protective Agents (Code: D020011) Sequestering Agents (Code: D064449) 1991-01-30 FDA
Click to view guanacline None
Click to view chlorphentermine Sodium-dependent serotonin transporter (Organism: Homo sapiens, class: Transporter, accessions: P31645, gene: SLC6A4, swissprot: SC6A4_HUMAN) substrate (Source: WOMBAT-PK) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) None (Source: WOMBAT-PK) A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223) Autonomic Agents (Code: D001337) Peripheral Nervous System Agents (Code: D018373) Sympathomimetics (Code: D013566) 1982-01-01 FDA
Click to view epinephrine Alpha-1D adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P25100, gene: ADRA1D, swissprot: ADA1D_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Alpha-1B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35368, gene: ADRA1B, swissprot: ADA1B_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) agonist (Source: DRUG MATRIX) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) agonist (Source: DRUG MATRIX) Alpha-2C adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18825, gene: ADRA2C, swissprot: ADA2C_HUMAN) agonist (Source: DRUG MATRIX) Arachidonate 15-lipoxygenase (Organism: Oryctolagus cuniculus, class: Enzyme, accessions: P12530, gene: ALOX15, swissprot: LOX15_RABIT) None (Source: DRUG MATRIX) Alpha-1B adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P15823, gene: Adra1b, swissprot: ADA1B_RAT) None (Source: DRUG MATRIX) Adrenergic receptor alpha-2 (Organism: Rattus norvegicus, class: GPCR, accessions: P19328|P22086|P22909, gene: Adra2a|Adra2b|Adra2c, swissprot: ADA2A_RAT|ADA2B_RAT|ADA2C_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Beta-2 adrenergic receptor (Organism: Canis familiaris, class: GPCR, accessions: P54833, gene: ADRB2, swissprot: ADRB2_CANFA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Adrenergic receptor beta (Organism: Rattus norvegicus, class: GPCR, accessions: P10608|P18090|P26255, gene: Adrb1|Adrb2|Adrb3, swissprot: ADRB1_RAT|ADRB2_RAT|ADRB3_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) D(1A) dopamine receptor (Organism: Homo sapiens, class: GPCR, accessions: P21728, gene: DRD1, swissprot: DRD1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Mu-type opioid receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P33535, gene: Oprm1, swissprot: OPRM_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Beta-1 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P18090, gene: Adrb1, swissprot: ADRB1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Beta-2 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P07550, gene: ADRB2, swissprot: ADRB2_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Beta-2 adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P10608, gene: Adrb2, swissprot: ADRB2_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Beta-1 adrenergic receptor (Organism: Cavia porcellus, class: GPCR, accessions: B0FL73, gene: ADRB1, swissprot: B0FL73_CAVPO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Alpha-1A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P35348, gene: ADRA1A, swissprot: ADA1A_HUMAN) agonist (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) None (Source: PDSP) Beta-1 adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08588, gene: ADRB1, swissprot: ADRB1_HUMAN) None (Source: PDSP) Alpha-1A adrenergic receptor (Organism: Rattus norvegicus, class: GPCR, accessions: P43140, gene: Adra1a, swissprot: ADA1A_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) M18 aspartyl aminopeptidase (Organism: Plasmodium falciparum (isolate 3D7), class: Unclassified, accessions: Q8I2J3, gene: None, swissprot: Q8I2J3_PLAF7) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL679) The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. alpha-Adrenergic Agonist (Code: N0000175552) beta-Adrenergic Agonist (Code: N0000175555) Catecholamine (Code: N0000175570) Catecholamines (Code: N0000007715) Adrenergic Agents (Code: D018663) Adrenergic Agonists (Code: D000322) Adrenergic alpha-Agonists (Code: D000316) Adrenergic beta-Agonists (Code: D000318) Anti-Asthmatic Agents (Code: D018927) Autonomic Agents (Code: D001337) Bronchodilator Agents (Code: D001993) Cardiovascular Agents (Code: D002317) Mydriatics (Code: D009184) Neurotransmitter Agents (Code: D018377) Peripheral Nervous System Agents (Code: D018373) Respiratory System Agents (Code: D019141) Sympathomimetics (Code: D013566) Vasoconstrictor Agents (Code: D014662) 1948-11-19 FDA 2HKK
4A7U
4LDO
Click to view methyprylon GABA-A receptor alpha-1/beta-3/gamma-2 (Organism: Homo sapiens, class: Ion channel, accessions: P14867|P18507|P28472, gene: GABRA1|GABRB3|GABRG2, swissprot: GBRA1_HUMAN|GBRB3_HUMAN|GBRG2_HUMAN) positive allosteric modulator (Source: WOMBAT-PK) None None FDA
Click to view epomediol marked choleretic activity in Wistar rats; mechanism of action may be related to increases in both the bile salt dependent & independent fractions of bile Cholagogues and Choleretics (Code: D002756) Gastrointestinal Agents (Code: D005765)
Click to view clortermine None
Click to view domiodol None
Click to view phosphorylcholine Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction. 5WP4

Click to view azelaic acid 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P31213, gene: SRD5A2, swissprot: S5A2_HUMAN) None (Source: WOMBAT-PK) None antineoplastic agent (Code: CHEBI:35610) dermatologic drug (Code: CHEBI:50177) Decreased Protein Synthesis (Code: N0000008841) Decreased Sebaceous Gland Activity (Code: N0000009982) Antineoplastic Agents (Code: D000970) Dermatologic Agents (Code: D003879) 1995-09-13 FDA 1TUF
5IZF
5IZJ
5J5X
Click to view barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression. Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) GABA Agents (Code: D018682) GABA Modulators (Code: D018757) Hypnotics and Sedatives (Code: D006993) Neurotransmitter Agents (Code: D018377)
Click to view mitoguazone S-adenosylmethionine decarboxylase proenzyme (Organism: Rattus norvegicus, class: Enzyme, accessions: P17708, gene: Amd1, swissprot: DCAM_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL216913) Amiloride-sensitive amine oxidase [copper-containing] (Organism: Rattus norvegicus, class: Enzyme, accessions: P36633, gene: Aoc1, swissprot: AOC1_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL216913) Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase. antineoplastic agent (Code: CHEBI:35610) Antineoplastic Agents (Code: D000970) Enzyme Inhibitors (Code: D004791)
Click to view enflurane Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1257) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1257) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1257) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1257) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1257) Glycine receptor subunit alpha-1 (Organism: Homo sapiens, class: Ion channel, accessions: P23415, gene: GLRA1, swissprot: GLRA1_HUMAN) positive modulator (Source: WOMBAT-PK) An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. anaesthetic (Code: CHEBI:38867) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) 1972-08-28 FDA
Click to view apronal None
Click to view undecylenic acid a fatty acid with a terminal double bond None FDA
Click to view piroctone 2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)- combined with 2-aminoethanol; used to treat pityriasis; structure given in first source antiseborrheic (Code: CHEBI:59010)
Click to view guanazodine synonyms EGYT-739 & Sanegyt (Sanegit) refers to sulfate; RN given refers to parent cpd
Click to view isoflurane Glycine receptor (alpha-1/beta) (Organism: Homo sapiens, class: Ion channel, accessions: P23415|P48167, gene: GLRA1|GLRB, swissprot: GLRA1_HUMAN|GLRB_HUMAN) positive modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) GABA-A receptor; anion channel (Organism: Homo sapiens, class: Ion channel, accessions: O00591|O14764|P14867|P18505|P18507|P28472|P31644|P34903|P47869|P47870|P48169|P78334|Q16445|Q8N1C3|Q99928|Q9UN88, gene: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ, swissprot: GBRA1_HUMAN|GBRA2_HUMAN|GBRA3_HUMAN|GBRA4_HUMAN|GBRA5_HUMAN|GBRA6_HUMAN|GBRB1_HUMAN|GBRB2_HUMAN|GBRB3_HUMAN|GBRD_HUMAN|GBRE_HUMAN|GBRG1_HUMAN|GBRG2_HUMAN|GBRG3_HUMAN|GBRP_HUMAN|GBRT_HUMAN) positive allosteric modulator (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) Potassium channel subfamily K member 10 (Organism: Homo sapiens, class: Ion channel, accessions: P57789, gene: KCNK10, swissprot: KCNKA_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) Potassium channel subfamily K member 18 (Organism: Homo sapiens, class: Ion channel, accessions: Q7Z418, gene: KCNK18, swissprot: KCNKI_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) Potassium channel subfamily K member 3 (Organism: Homo sapiens, class: Ion channel, accessions: O14649, gene: KCNK3, swissprot: KCNK3_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) Potassium channel subfamily K member 9 (Organism: Homo sapiens, class: Ion channel, accessions: Q9NPC2, gene: KCNK9, swissprot: KCNK9_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) Potassium channel subfamily K member 2 (Organism: Homo sapiens, class: Ion channel, accessions: O95069, gene: KCNK2, swissprot: KCNK2_HUMAN) opener (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1256) 5-hydroxytryptamine receptor 2B (Organism: Homo sapiens, class: GPCR, accessions: P41595, gene: HTR2B, swissprot: 5HT2B_HUMAN) None (Source: PDSP) A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. inhalation anaesthetic (Code: CHEBI:38870) Anesthetics (Code: D000777) Anesthetics, General (Code: D018681) Anesthetics, Inhalation (Code: D018685) Central Nervous System Agents (Code: D002491) Central Nervous System Depressants (Code: D002492) General Anesthesia (Code: N0000175975) General Anesthetic (Code: N0000175681) 1979-12-18 FDA 1XZ3
3F78
4Z90
4Z91
Click to view ribavirin Inosine-5'-monophosphate dehydrogenase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P20839, gene: IMPDH1, swissprot: IMDH1_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6842) DNA topoisomerase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P11387, gene: TOP1, swissprot: TOP1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1643) NS5B protein (Organism: Hepatitis C virus, class: Enzyme, accessions: Q8JXU8, gene: NS5B, swissprot: Q8JXU8_9HEPC) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1643) Cytosolic purine 5'-nucleotidase (Organism: Homo sapiens, class: Enzyme, accessions: P49902, gene: NT5C2, swissprot: 5NTC_HUMAN) None (Source: WOMBAT-PK) Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Organism: Homo sapiens, class: Enzyme, accessions: P22413, gene: ENPP1, swissprot: ENPP1_HUMAN) None (Source: WOMBAT-PK) Adenosine kinase (Organism: Homo sapiens, class: Kinase, accessions: P55263, gene: ADK, swissprot: ADK_HUMAN) None (Source: WOMBAT-PK) Inosine-5'-monophosphate dehydrogenase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P12268, gene: IMPDH2, swissprot: IMDH2_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6842) A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses. Nucleoside Analog (Code: N0000175459) Nucleoside Analog Antiviral (Code: N0000175466) antiinfective agent (Code: CHEBI:35441) Anti-Infective Agents (Code: D000890) Antimetabolites (Code: D000963) Antiviral Agents (Code: D000998) Noxae (Code: D009676) 1985-12-31 FDA 3SFU
4PB1
5AXD
Click to view secnidazole 3-oxoacyl-[acyl-carrier-protein] synthase 3 (Organism: Escherichia coli, class: Enzyme, accessions: C3TDZ2, gene: fabH, swissprot: C3TDZ2_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL498847) Secnidazole is a 5-nitroimidazole antimicrobial. 5-nitroimidazoles enter the bacterial cell as an inactive prodrug where the nitro group is reduced by bacterial enzymes to radical anions. It is believed that these radical anions interfere with bacterial DNA synthesis of susceptible isolates. Nitroimidazole Antimicrobial (Code: N0000175435) Nitroimidazoles (Code: N0000007663) Anti-Infective Agents (Code: D000890) Antiparasitic Agents (Code: D000977) Antiprotozoal Agents (Code: D000981) 2017-09-15 FDA
Click to view amanozine None 5X4M
Click to view procymate None
Click to view amphenidone None
Click to view selenomethionine Diagnostic aid in pancreas function determination. None FDA 4FY0
4DLP
4QGN
Click to view mafenide Carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: C0IX24, gene: CA2, swissprot: C0IX24_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Delta carbonic anhydrase (Organism: Thalassiosira weissflogii, class: Unclassified, accessions: Q5U9J1, gene: ca1, swissprot: Q5U9J1_THAWE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 5A, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: P35218, gene: CA5A, swissprot: CAH5A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), class: Enzyme, accessions: P53615, gene: NCE103, swissprot: CAN_YEAST) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 2 (Organism: Homo sapiens, class: Enzyme, accessions: P00918, gene: CA2, swissprot: CAH2_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 14 (Organism: Homo sapiens, class: Enzyme, accessions: Q9ULX7, gene: CA14, swissprot: CAH14_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H), class: Enzyme, accessions: Q50565, gene: None, swissprot: Q50565_METTH) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 7 (Organism: Homo sapiens, class: Enzyme, accessions: P43166, gene: CA7, swissprot: CAH7_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 13 (Organism: Mus musculus, class: Enzyme, accessions: Q9D6N1, gene: Ca13, swissprot: CAH13_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 12 (Organism: Homo sapiens, class: Enzyme, accessions: O43570, gene: CA12, swissprot: CAH12_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 9 (Organism: Homo sapiens, class: Enzyme, accessions: Q16790, gene: CA9, swissprot: CAH9_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Helicobacter pylori (strain ATCC 700392 / 26695), class: Enzyme, accessions: O24855, gene: cynT, swissprot: CYNT_HELPY) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 15 (Organism: Mus musculus, class: Enzyme, accessions: Q99N23, gene: Ca15, swissprot: CAH15_MOUSE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Alpha carbonic anhydrase (Organism: Stylophora pistillata, class: Unclassified, accessions: B5SU02, gene: CA, swissprot: B5SU02_9CNID) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P96878, gene: None, swissprot: P96878_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P22748, gene: CA4, swissprot: CAH4_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 1 (Organism: Homo sapiens, class: Enzyme, accessions: P00915, gene: CA1, swissprot: CAH1_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Astrosclerin-3 (Organism: Astrosclera willeyana, class: Unclassified, accessions: A6YCJ1, gene: None, swissprot: A6YCJ1_9METZ) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 5B, mitochondrial (Organism: Homo sapiens, class: Enzyme, accessions: Q9Y2D0, gene: CA5B, swissprot: CAH5B_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Candida albicans (strain SC5314 / ATCC MYA-2876), class: Enzyme, accessions: Q5AJ71, gene: NCE103, swissprot: CAN_CANAL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Methanosarcina thermophila, class: Enzyme, accessions: P40881, gene: None, swissprot: CAH_METTE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Beta-carbonic anhydrase 1 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ7, gene: mtcA1, swissprot: MTCA1_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 2 (Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), class: Enzyme, accessions: P9WPJ9, gene: mtcA2, swissprot: MTCA2_MYCTU) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 6 (Organism: Homo sapiens, class: Enzyme, accessions: P23280, gene: CA6, swissprot: CAH6_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase 4 (Organism: Bos taurus, class: Enzyme, accessions: Q95323, gene: CA4, swissprot: CAH4_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Dihydropteroate synthase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P0AC13, gene: folP, swissprot: DHPS_ECOLI) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Anopheles gambiae, class: Unclassified, accessions: Q5TU56, gene: None, swissprot: Q5TU56_ANOGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) Carbonic anhydrase (Organism: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65), class: Enzyme, accessions: Q6FTL6, gene: None, swissprot: Q6FTL6_CANGA) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL419) A sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy. Methylated Sulfonamide Antibacterial (Code: N0000175511) Methylated Sulfonamides (Code: N0000175512) Anti-Infective Agents (Code: D000890) Anti-Infective Agents, Local (Code: D000891) 1969-01-24 FDA 5JNC
Click to view carbimazole Lactoperoxidase (Organism: Homo sapiens, class: Enzyme, accessions: P22079, gene: LPO, swissprot: PERL_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL508102) Thyroid peroxidase (Organism: Homo sapiens, class: Enzyme, accessions: P07202, gene: TPO, swissprot: PERT_HUMAN) inhibitor (Source: WOMBAT-PK) An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity. prodrug (Code: CHEBI:50266) antithyroid drug (Code: CHEBI:50671) Antithyroid Agents (Code: D013956) Hormone Antagonists (Code: D006727) Hormones, Hormone Substitutes, and Hormone Antagonists (Code: D006730) 1959-01-01 YEAR INTRODUCED
Click to view cyclobutyrol None bile therapy drug (Code: CHEBI:61026)
Click to view capuride None
Click to view aminitrozole None 1971-05-27 Ministry of Health of the Russian Federation
Click to view amrinone cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Organism: Homo sapiens, class: Enzyme, accessions: Q14432, gene: PDE3A, swissprot: PDE3A_HUMAN) inhibitor (Source: WOMBAT-PK) Phosphodiesterase 4 (Organism: Homo sapiens, class: Enzyme, accessions: P27815|Q07343|Q08493|Q08499, gene: PDE4A|PDE4B|PDE4C|PDE4D, swissprot: PDE4A_HUMAN|PDE4B_HUMAN|PDE4C_HUMAN|PDE4D_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL12856) cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Organism: Homo sapiens, class: Enzyme, accessions: Q13370, gene: PDE3B, swissprot: PDE3B_HUMAN) inhibitor (Source: http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7202) A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. Calcium Channel Blockers (Code: D002121) Cardiotonic Agents (Code: D002316) Cardiovascular Agents (Code: D002317) Enzyme Inhibitors (Code: D004791) Membrane Transport Modulators (Code: D049990) Phosphodiesterase 3 Inhibitors (Code: D058987) Phosphodiesterase Inhibitors (Code: D010726) Protective Agents (Code: D020011) Vasodilator Agents (Code: D014665) 1984-07-31 FDA
Click to view phendimetrazine 5-hydroxytryptamine receptor 1A (Organism: Homo sapiens, class: GPCR, accessions: P08908, gene: HTR1A, swissprot: 5HT1A_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1744) Sodium-dependent dopamine transporter (Organism: Homo sapiens, class: Transporter, accessions: Q01959, gene: SLC6A3, swissprot: SC6A3_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1744) Sodium-dependent noradrenaline transporter (Organism: Homo sapiens, class: Transporter, accessions: P23975, gene: SLC6A2, swissprot: SC6A2_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1744) a sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure Appetite Suppression (Code: N0000175372) Increased Sympathetic Activity (Code: N0000175651) Sympathomimetic Amine Anorectic (Code: N0000175423) Central Nervous System Agents (Code: D002491) Central Nervous System Stimulants (Code: D000697) 1976-07-28 FDA
Click to view pivagabine None
Click to view selegiline Alpha-2A adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P08913, gene: ADRA2A, swissprot: ADA2A_HUMAN) None (Source: DRUG MATRIX) Alpha-2B adrenergic receptor (Organism: Homo sapiens, class: GPCR, accessions: P18089, gene: ADRA2B, swissprot: ADA2B_HUMAN) None (Source: DRUG MATRIX) Amine oxidase [flavin-containing] A (Organism: Rattus norvegicus, class: Enzyme, accessions: P21396, gene: Maoa, swissprot: AOFA_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Amine oxidase [flavin-containing] A (Organism: Homo sapiens, class: Enzyme, accessions: P21397, gene: MAOA, swissprot: AOFA_HUMAN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Amine oxidase [flavin-containing] A (Organism: Bos taurus, class: Enzyme, accessions: P21398, gene: MAOA, swissprot: AOFA_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Amine oxidase [flavin-containing] B (Organism: Bos taurus, class: Enzyme, accessions: P56560, gene: MAOB, swissprot: AOFB_BOVIN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Amine oxidase [flavin-containing] B (Organism: Homo sapiens, class: Enzyme, accessions: P27338, gene: MAOB, swissprot: AOFB_HUMAN) inhibitor (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Amine oxidase [flavin-containing] B (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643, gene: Maob, swissprot: AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) Monoamine oxidase (Organism: Rattus norvegicus, class: Enzyme, accessions: P19643|P21396, gene: Maoa|Maob, swissprot: AOFA_RAT|AOFB_RAT) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL972) A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. Monoamine Oxidase Inhibitor (Code: N0000175744) Monoamine Oxidase Type B Inhibitor (Code: N0000175762) Monoamine Oxidase-B Inhibitors (Code: N0000175761) Anti-Dyskinesia Agents (Code: D018726) Antiparkinson Agents (Code: D000978) Central Nervous System Agents (Code: D002491) Enzyme Inhibitors (Code: D004791) Monoamine Oxidase Inhibitors (Code: D008996) Neuroprotective Agents (Code: D018696) Protective Agents (Code: D020011) 1989-06-05 FDA
Click to view clavulanic acid Beta-lactamase TEM (Organism: Escherichia coli, class: Enzyme, accessions: P62593, gene: bla; blaT-3; blaT-4;, swissprot: BLAT_ECOLX) inhibitor (Source: WOMBAT-PK) Beta-lactamase GES-13 (Organism: Pseudomonas aeruginosa, class: Enzyme, accessions: D1MIX9, gene: blaGES-13, swissprot: D1MIX9_PSEAI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Citrobacter gillenii, class: Enzyme, accessions: A4KCT8, gene: BlaGIL-1, swissprot: A4KCT8_9ENTR) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: P05364, gene: ampC, swissprot: AMPC_ENTCL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q9EXV5, gene: blaUOE-1, swissprot: Q9EXV5_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Carbapenem-hydrolizing beta-lactamase SFC-1 (Organism: Serratia fonticola, class: Enzyme, accessions: Q6JP75, gene: None, swissprot: Q6JP75_SERFO) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Carbepenem-hydrolyzing beta-lactamase KPC (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q9F663, gene: bla, swissprot: BLKPC_KLEPN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: Q6GWS8, gene: blaTEM-125, swissprot: Q6GWS8_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Escherichia coli (strain K12), class: Enzyme, accessions: P00811, gene: ampC, swissprot: AMPC_ECOLI) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Salmonella enterica subsp. enterica serovar Westhampton, class: Enzyme, accessions: Q2XPY6, gene: blaCTX-M-53, swissprot: Q2XPY6_SALET) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228), class: Enzyme, accessions: P24735, gene: ampC, swissprot: AMPC_PSEAE) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: A0ZX81, gene: blaSHV-72, swissprot: A0ZX81_KLEPN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase SHV-5 (Organism: Klebsiella pneumoniae, class: Unclassified, accessions: P0A3M1, gene: bla, swissprot: BLA5_KLEPN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Citrobacter freundii, class: Enzyme, accessions: A2RP81, gene: blaPER-2, swissprot: A2RP81_CITFR) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase SHV-1 (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: P0AD64, gene: bla, swissprot: BLA1_KLEPN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Bacillus clausii, class: Enzyme, accessions: A8RR46, gene: bcl1, swissprot: A8RR46_BACCS) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Escherichia coli, class: Enzyme, accessions: A1E3K9, gene: blaSCO-1, swissprot: A1E3K9_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Enterobacter cloacae, class: Enzyme, accessions: Q59401, gene: None, swissprot: Q59401_ENTCL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase SHV-1 (Organism: Escherichia coli, class: Enzyme, accessions: P0AD63, gene: bla, swissprot: BLA1_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase OXA-1 (Organism: Escherichia coli, class: Enzyme, accessions: P13661, gene: bla, swissprot: BLO1_ECOLX) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Klebsiella pneumoniae, class: Enzyme, accessions: Q4TVR4, gene: blaSHV-55, swissprot: Q4TVR4_KLEPN) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Class D beta-lactamase (Organism: Brachyspira pilosicoli, class: Unclassified, accessions: Q50H31, gene: oxa-63, swissprot: Q50H31_BRAPL) None (Source: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL777) Beta-lactamase (Organism: Staphylococcus aureus, class: Enzyme, accessions: P00807, gene: blaZ, swissprot: BLAC_STAAU) None (Source: WOMBAT-PK) Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antib